ID L5M710_MYODS Unreviewed; 434 AA.
AC L5M710;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Acyl-coenzyme A amino acid N-acyltransferase 2 {ECO:0000313|EMBL:ELK34176.1};
GN ORFNames=MDA_GLEAN10021519 {ECO:0000313|EMBL:ELK34176.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK34176.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
CC {ECO:0000256|ARBA:ARBA00006538}.
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DR EMBL; KB103229; ELK34176.1; -; Genomic_DNA.
DR RefSeq; XP_006758482.1; XM_006758419.2.
DR AlphaFoldDB; L5M710; -.
DR MEROPS; S09.A50; -.
DR GeneID; 102764710; -.
DR eggNOG; ENOG502QQ8Z; Eukaryota.
DR OrthoDB; 5356064at2759; -.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR GO; GO:0006637; P:acyl-CoA metabolic process; IEA:InterPro.
DR Gene3D; 2.60.40.2240; Acyl-CoA thioester hydrolase/BAAT N-terminal domain; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR016662; Acyl-CoA_thioEstase_long-chain.
DR InterPro; IPR014940; BAAT_C.
DR InterPro; IPR006862; Thio_Ohase/aa_AcTrfase.
DR InterPro; IPR042490; Thio_Ohase/BAAT_N.
DR PANTHER; PTHR10824:SF1; ACYL-COENZYME A AMINO ACID N-ACYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR10824; ACYL-COENZYME A THIOESTERASE-RELATED; 1.
DR Pfam; PF08840; BAAT_C; 1.
DR Pfam; PF04775; Bile_Hydr_Trans; 1.
DR PIRSF; PIRSF016521; Acyl-CoA_hydro; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:ELK34176.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Transferase {ECO:0000313|EMBL:ELK34176.1}.
FT DOMAIN 14..142
FT /note="Acyl-CoA thioester hydrolase/bile acid-CoA amino
FT acid N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04775"
FT DOMAIN 204..428
FT /note="BAAT/Acyl-CoA thioester hydrolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08840"
FT ACT_SITE 233
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 327
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 361
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
SQ SEQUENCE 434 AA; 47758 MW; 757AB9CA6A7ABCB9 CRC64;
MFQLTATPAS ALSDEPVHIR ATGLPPLQLV TLAASLRDEK GHLYRSKAFY RADEAGELDL
KQAPAVGGDY VGVHPMGLFW SMKPDRPFGR LLKRDVNSPF VVTLDLYDSV CSHDSATAQP
RASQVVQRWF RSPGTQRVPI REGRVRGALF LPPGEGPFPG IVDMFGGIGG LVEFRASLLA
AHGFAVLALA YFAYEDLPKL LKVVDLEYFE EAANLLLAHP KVRGPGIGVL SVSKGAEIGL
AMACFLKQVV ATVCINGPTA LYDFPFRYRG LVMSPIPSFL ELMRVHVSGA VSLLHYRGDP
REKLNQRSVF PIEKAQGQIL FIIGEDDQSI NSKEYAKQAL EQLKSHGRSN GRMLLYPGAG
HLLEPPYAPL CYASRIYSIS ALLNNLISLS YNYSFTQPLL WGGDPAAHAA AQEHAWGEIQ
KFFRQHLTQT RSEL
//
