ID L5MCJ0_MYODS Unreviewed; 1821 AA.
AC L5MCJ0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Myosin-Vc {ECO:0000313|EMBL:ELK36037.1};
GN ORFNames=MDA_GLEAN10016327 {ECO:0000313|EMBL:ELK36037.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK36037.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KB101809; ELK36037.1; -; Genomic_DNA.
DR eggNOG; KOG0160; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15476; Myo5c_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037991; Myo5c_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT DOMAIN 95..149
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 154..843
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1500..1776
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 722..744
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 974..1086
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1116..1188
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1301..1346
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1382..1430
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 248..255
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1821 AA; 209920 MW; 506227C59E241142 CRC64;
MCRGSHCLQP LFLLPDSSHP EASLIVALVS PRTAVLLLDS AAACPLLDRR ACLGTATQLP
LFQGSKDPGS RTLGQQQSQS QWNVGLESLP EFGGQEYNRV WIPDPEDVWK SAEIAKDYRV
GDKVLRLLLE DGTELDYSVD PESLPPLRNP DILVGENDLT ALSYLHEPAV LHNLRIRFAE
SKLIYTYSGI ILVAMNPYKQ LPIYGDAIIH AYSGQNMGDM DPHIFAVAEE AYKQMARNNK
NQSIIVSGES GAGKTVSARY AMRYFATVSK SNSNAHVEDK VLASNPITEA VGNAKTTRND
NSSRFGKYTE ISFDERNQII GANMRTYLLE KSRVVFQSEN ERNYHIFYQL CASAQQSEFK
HLKLGSAEEF NYTRMGGNTV IEGVSDSAGM EETRKTFTLL GFQEDFQMDV FKVLAAILHL
GNVQITAVGN ERSAVSADDS HLQVFCELLG LERGSVAQWL CNRKIITTSE TVVKPMTRPQ
AANARDALAK KVYAHLFDFI VERINQALQF SGKQHTFIGV LDIYGFETFD VNSFEQFCIN
YANEKLQQQF NLHVFKLEQE EYMKEDIPWT LIDFYDNQSV IDLIEAKMGI LELLDEECLL
PHGTDENWLQ KLYNNFINKN SLFEKPRMSN ASFIIQHFAD KVEYKCEGFL EKNRDTVYDM
LVEILRASKF HLCAKFFQES PVPPSPFGSA ITMKSAKQVI KPNNKQFRTT VGSKVSGGLG
SLSLLMETLN ATTPHYVRCI KPNDEKLPFE FDSKRIVQQL RACGVLETIR ISAQSYPSRW
TYIEFYSRYG ILMTKQELSF GDKKEVCKVV LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK
LRLDKLRQGC VVIQKHIRGW LQRKKFLRQR QAALTIQQYF RGQHTVRKAV TAAALKEAWA
AIIIQKHCRG YLVRSLYQLI RVATITIQAY TRGCLARRRY RKMLEEHKAV ILQKYARAWL
ARRRFQSIRR FVLNIQLTYR VQRLQKKLED QNRENHGLME KLTSLAAARA GDVEKVQKLE
SELDRAAAHR RNYEERGQRY KATVEEKLAK LQKHNSELEV QKEQIQRKLQ EQTEELKGKM
DDLTKQLFED VQKEEQQRIL LEKSFELKTQ DYEKQMCSLK EEVKALKDEK MQLQRQLEEE
QATSGGLQGE VARLSQQAKT ISEFEKEIEL LQTQKIDVEK HVQSQKREMR EKMSEITKQL
LESYDIADVR SRLSVEDLEH LNEDGELWFA YEGLKKATRV LESHFQSQKD CYEKEIEALN
FKVVHLSQEI NHLQKLFREE NDINESIRHE VTRLTSENMM IPDFKQQISE LEKQKQDLEI
RLNEQTESMR GKLEEFSNEL NHTREEEGIH PEEKEKLMDD IHAMPEVSKG LKKQVETEPK
VESSLRQDAS RLTMENRDLE EELDMKDRVI KKLQDQVKSL TKTIGKANDV HLSSGPKEYL
GMLEYKREDE AKLIQNLILD LKPRGVVVNM IPGLPAHILF MCVRYADSLN DASMLKSLMN
SIINGIKQVV KEHLEDFEML SFWLSNTCHF LNCLKQYSGE EEFMKHNSPH QNKNCLNNFD
LSEYRQILSD VAIRIYHQFI IVMENNIQPI IVPGMLEYES LQGISGLKPT GFRKRSSSID
DTDAYTMTSV LQQLSYFYST MCQNGLDPEL VRQAVKQLFF LIGAVTLNSL FLRKDMCSCR
KGMQIRCNIS YLEEWLKDKN LQNSLAKETL EPLSQAAWLL QVKKITDSDA KEIFERCTSL
SAVQIIKILN LYTPIDDFEK RVTPSFVRKV QALLNSREDS SQLMLDASYL FQVVFPFTPS
PHALEMIEIP SSFKLGFLNR L
//
