ID   L7FQN5_ENTIV            Unreviewed;      1700 AA.
AC   L7FQN5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein {ECO:0000259|Pfam:PF07699};
GN   ORFNames=EIN_039030 {ECO:0000313|EMBL:ELP94683.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP94683.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP94683.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP94683.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB206183; ELP94683.1; -; Genomic_DNA.
DR   RefSeq; XP_004261454.1; XM_004261406.1.
DR   EnsemblProtists; ELP94683; ELP94683; EIN_039030.
DR   GeneID; 14893658; -.
DR   KEGG; eiv:EIN_039030; -.
DR   VEuPathDB; AmoebaDB:EIN_039030; -.
DR   OrthoDB; 201677at2759; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   PANTHER; PTHR46967; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL; 1.
DR   PANTHER; PTHR46967:SF2; KERATIN-ASSOCIATED PROTEIN 16-1-LIKE; 1.
DR   Pfam; PF07699; Ephrin_rec_like; 1.
DR   SMART; SM01411; Ephrin_rec_like; 4.
DR   SMART; SM00261; FU; 4.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1700
FT                   /note="Tyrosine-protein kinase ephrin type A/B receptor-
FT                   like domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005688091"
FT   TRANSMEM        1550..1572
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1412..1455
FT                   /note="Tyrosine-protein kinase ephrin type A/B receptor-
FT                   like"
FT                   /evidence="ECO:0000259|Pfam:PF07699"
FT   REGION          1593..1700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1593..1641
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1642..1657
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1658..1684
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1685..1700
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1700 AA;  188681 MW;  157BD41B7DCBE08C CRC64;
     MYNVLFNIFV LLITSTNSAV FTWSSGSGYF DSSTHWSPQG IPDSGDTAVI CPTTASEIIL
     RTSTQSTILF GGETCSESVL KITSNDVTIN SLQVLMKGSV LLSSNTLNTS LLAINGKFES
     EIATLINTNS LEVKQNGVVN GKMNLNVTST TLITGSVNIT TLTTNSLTLN SITMNAKSVT
     SNNINGIGVI NGKVYLDGEV TLSNTIEVKG EVEMNNVNLK NFFSKVSGLI AIDSSITSPQ
     SSVISGGDIY LESSTLELFS LENIQNFDVI GISKLVTVKG SSNTQIRIAR TAELLIDKGQ
     GEFNTQSGKV CIKEGAVNGV FNSELTIEKN VTLNGNVIGN VECVNGGEFL KSNVVFNEIK
     EFTCKATISI LTFKQDVEIL NGKITNCSLI VEKSANYIHN SESTFVTIHN NIFTIEDVKS
     NLYYDGVALV VKQNVVASKL EQKSGVLIVK GNENNLMAFD VGEISIQNAN FTNVKMEKTK
     NIFVETGFDV LCENCVVDGT QFDGSPNRLE GRNSLFKNCK INSEIHFIDS IVEGSTCKNV
     FSEATNNFTN SKFSKITVNE SSELLFIDSF VIVQMVNNGK VINRSPTVAL INNLNGLFVS
     EIDECYIQFT NYGTMNFIEK TQNIILNAIS FNYGIISGFG KFTIEAYQFT NGGYLKSGTK
     FIDSAVTIYK NSTFEDQTIT FERCSFTFPN GSPLFNEVIL TVSAESQTPL LATGLQLKKL
     QNRNKVFKFL TNDLEISDST LNEQKLELEG IPVVIQNSVI PTISLTNCTV SLSATVFTTL
     ETNYCDISDD ISTQLLKSQN SNFQKVESKT LEVSNVTIAY LEVSESTSLH NVAPDTVSAP
     LYSILSGINL QSALTVNGFF HFKNLNLESN EAHKVELVSN VVPFIIEDTT IISVTLPSVI
     TRGNVVLTDI TANSVINIGN LSISSKEKTM IESLRLLANS SLVSQKQFEI SHFYVGVNVQ
     TDIQELTISK ELSFDGDLHF STVVLLENCV ITCPKTSKIY TETIVSFKSN VFKIPVFVKK
     HCAELNISGS GVLVTEESFK GSCIDSHIEY MQNYGEYVGG DGLQMVENYG MFVLQDETFQ
     RAIDNHGILQ MNNGRIDSES RVHLFPYSIV RGNGYIREMD VQTEDTRKSM KTDIELNYDN
     LVNHLEGYSL ERTTQNYNNG GDETLDIKST IKEEALPILD IDGQLRVSLC LSNMLIVKIK
     IFEDLNDLLI FDEFYDYMMN FDITITDFAI YDAKNYTVFE FGRGDFVPRL SVDFVNIENY
     LETPWRYGQT DNSLYVEFNG CEFVYNTETK KCKECEAGEI FNNVTHLCDG CELGMIYTTA
     GICIPCPEGT YSSNNLCVKC PADEVSPVQS SFCTKCEDGS LPNENNSKCE YCPVGTRLEK
     NSEFTKCLPC SAGTYRDENL ITMNDCTECP IGTYSSHNGA FECSKCPLGF YSDAVGSKTC
     KKCEDGYYTI NTGSVTCERC EDGHYSSPNG GECLTCPSGF ERGEFGCIWC KAGFYKGGDG
     IKCVECPEGF YQEKQGMAYC NECDGKKQVN LNKTKCENRP SEPDTVAMTI TYSLFPLIVA
     LCCGLGCGAA WMDDRKERKK KKMMAIAEVQ KEEEHKLIES EEHEEEQNIQ EEKKNEEIKK
     KMEEKNVNMN EKENGITKEE IEMEEIEQEE SFDIEDIEQM IESIKNKPQK NEEDRKEEDV
     KESSQNDMQN INNELKEQVH
//