ID L7MRJ4_HORSE Unreviewed; 219 AA.
AC L7MRJ4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 22-FEB-2023, entry version 30.
DE RecName: Full=Calcyclin-binding protein {ECO:0000256|ARBA:ARBA00015702};
DE Flags: Fragment;
GN Name=CACYBP {ECO:0000313|EMBL:AEB61154.1};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|EMBL:AEB61154.1};
RN [1] {ECO:0000313|EMBL:AEB61154.1}
RP NUCLEOTIDE SEQUENCE.
RA Waegele B., Farthmann B., Nyakatura G., Heubner D., Mewes H.-W.,
RA Steinbach F.;
RT "Analysis of a normalized equine cDNA library using deep sequencing.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in calcium-dependent ubiquitination and
CC subsequent proteasomal degradation of target proteins. Probably serves
CC as a molecular bridge in ubiquitin E3 complexes. Participates in the
CC ubiquitin-mediated degradation of beta-catenin (CTNNB1).
CC {ECO:0000256|ARBA:ARBA00025145}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; HQ889999; AEB61154.1; -; mRNA.
DR AlphaFoldDB; L7MRJ4; -.
DR HOGENOM; CLU_081441_2_0_1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0044548; F:S100 protein binding; IEA:InterPro.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR CDD; cd06468; p23_CacyBP; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR037201; CacyBP_N.
DR InterPro; IPR037893; CS_CacyBP.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR007699; SGS_dom.
DR InterPro; IPR015120; Siah-Interact_N.
DR PANTHER; PTHR13164:SF3; CALCYCLIN-BINDING PROTEIN; 1.
DR PANTHER; PTHR13164; CALICYLIN BINDING PROTEIN; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF05002; SGS; 1.
DR Pfam; PF09032; Siah-Interact_N; 1.
DR SUPFAM; SSF140106; Calcyclin-binding protein-like; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS51048; SGS; 1.
PE 2: Evidence at transcript level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 64..158
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT DOMAIN 142..219
FT /note="SGS"
FT /evidence="ECO:0000259|PROSITE:PS51048"
FT COILED 17..48
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEB61154.1"
SQ SEQUENCE 219 AA; 25160 MW; 83CBC92B72A50B66 CRC64;
LEEVKVLLEK ATRKRVRDAL TAEKSKIETE IKNKMQQKSQ KKAELLDNEK PAAVVAPITT
GYTVKISNYG WDQSDKFVKI YITLPGVHQV PTENVQVHFT ERSFDLLVKN LNGKSYSMIV
NNLLKPISVE GSSKKVKTDT VLILCRKKAE NTRWDYLTQV EKECKEKEKP SYDTETDPSE
GLMNVLKKIY EDGDDDMKRT INKAWVESRE KQAKGETEF
//
