ID L7N0T8_CIOIN Unreviewed; 555 AA.
AC L7N0T8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Integrin alpha third immunoglobulin-like domain-containing protein {ECO:0000259|Pfam:PF20806};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000019503.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000019503.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; EAAA01002975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; L7N0T8; -.
DR STRING; 7719.ENSCINP00000019503; -.
DR Ensembl; ENSCINT00000019503.3; ENSCINP00000019503.3; ENSCING00000009593.3.
DR GeneTree; ENSGT00940000165133; -.
DR HOGENOM; CLU_511842_0_0_1; -.
DR InParanoid; L7N0T8; -.
DR OMA; NITHDHT; -.
DR Proteomes; UP000008144; Chromosome 9.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 485..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 302..463
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 518..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 61207 MW; 13FF870BAF5A2C2E CRC64;
INVTMKLDSL LGNQGNKRLV FAGTTSSIHI KVYNVTSSRV CFTLPVQLNP AYFESTLSTG
DFGIVSRLEV SYDYTTSHKN TIMSAMLDPW SPRVTTADWS FQKKCSEMKG TRCSHDLKIE
TAYSVPSHVV MSQPLILGSN PGLLSINVTI TNLGPDHSYF TRINVVGNLD LTKVVGTCVT
IIGQTNMPND TTVTFKSANS NLPGFMFKDE KCFFILEYSL ESLTKKAIVR EILLKGSVYS
GANDTANVID PMMHNNQFEL RKQVFYTATI AHTSNSVPNS MFYNRTVSPL ASIHNINNEF
LGGSTYAVFH KHSIENRGPN LVAKASLVFT WPRQTKEGLP LLYLYHFQCL PLTLCHCATM
EKVNEYGLAI NNGTGLKNIS IDFNSNTVLP TDTTCNDVKC DSITCTVNQL GKFSTVVVTS
SFKVWLPTLT QNNLATKLSS KTSFNVTDSP IYNLAATTTT ATTVVSKYLP PVPPIDQSKL
DIGPLIGAIV GGIVLLVVIM LIMWKVGFFK SKYAKMRREA ENTDDNHESE HKDDSHAGAE
NTDDNEITVQ TNADE
//
