ID L7N186_MYOLU Unreviewed; 679 AA.
AC L7N186;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004803.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004803.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004803.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02051949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02051950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02051951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; L7N186; -.
DR Ensembl; ENSMLUT00000005265.2; ENSMLUP00000004803.2; ENSMLUG00000025304.1.
DR GeneTree; ENSGT01100000263478; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd16843; IgC2_D1_D2_LILR_KIR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF179; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..679
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003982356"
FT TRANSMEM 647..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..197
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 224..311
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 321..393
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 679 AA; 74400 MW; EC03D52B872D05E3 CRC64;
MTSILSALLC LGLSLDQRTR VQAGTHPKPT IWAEPGPVIF WESPVTIWCQ GTPRAEEYRL
YKVGSTASLD QQKPLDSGDR AKFSITQMTM LDAGRYGCYY RSPSGQSEHS DTLELVVTVG
CYSKPSLSAL PSPVVTSGGN VTLQCGSGQG FHRFILTKEG DHRLSWTQDS EPQISGQFQA
LFTVGPVTPT QRWRFRCYGC YRNRPYVWSL PSDALELLVP GTFPKPTLWA EPGSLINWGS
SVTIWCQGTP EAEEYRLYKE GSTAWWYQQK TLDPGDRAKF SIRHMTDPDA GRYRCYYRSP
SGRSESSNPL ELVVTGSFSK PSLSAMPSPV VTAGGNVTLQ CGAGEGFYRF ILTKEGDHRF
SWALDSQPQT SGQNQALFPV GPVTPTQKWR FRCYGCYRNR PNVCSLPSDA LELLVPGESG
KPSLLSQQGP IVASGQSLTL QCHSDVGYDR FALHKEGRRD LPESLVLRPQ AGLSQAHFPL
GTVSSSHGGR YRCYGGYNLS SEWSAPSDPL DILVAGEEPV GPFLSVRPGP GVASGENVTL
LCQSQSWMNT FLLSKEGATD PPLGLRSKPG AQQFQAEFSI SPVTSAHGGT YRCYSSLSTS
SFLLSLPSEP LELLVSGLIL SLWTSPERGS CPTSCRNHTP QGKNSPIRMG VVALLLVMLR
VLLFLARNSQ RRTHNVARV
//
