ID L7N300_XENTR Unreviewed; 692 AA.
AC L7N300;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Protein-glutamine gamma-glutamyltransferase 5 {ECO:0000313|RefSeq:XP_031750711.1};
DE SubName: Full=Transglutaminase 3-like, gene 1 {ECO:0000313|Ensembl:ENSXETP00000016022};
GN Name=tgm3l {ECO:0000313|Xenbase:XB-GENE-6258365};
GN Synonyms=tgm3l.1 {ECO:0000313|Ensembl:ENSXETP00000016022,
GN ECO:0000313|RefSeq:XP_031750711.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000016022};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000016022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000016022};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000016022}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031750711.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031750711.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031750711.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR RefSeq; XP_031750711.1; XM_031894851.1.
DR Ensembl; ENSXETT00000016022; ENSXETP00000016022; ENSXETG00000007357.
DR KEGG; xtr:100486088; -.
DR AGR; Xenbase:XB-GENE-6258365; -.
DR Xenbase; XB-GENE-6258365; tgm3l.
DR eggNOG; ENOG502QTRA; Eukaryota.
DR HOGENOM; CLU_013435_1_0_1; -.
DR OMA; ISGGTYC; -.
DR Proteomes; UP000008143; Chromosome 10.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF38; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 5; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 269..361
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 277
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 335
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 358
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 398
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 400
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 446
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 451
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 692 AA; 77308 MW; 717C83F2CE0DCABA CRC64;
MTFPPELSGI DFDLLKNVQE HRTQGIRGMG LVVRRGWPFT MKMQFRYLGQ DAKLENLNLI
AQIGPYPSPH TGTHIYFPVS RLRDNRSWSA EMEGENNGVL AVKVQTPATA IIGRYSLSLE
GSYRGMPVSH ILGNVVLLFN PWCPEDDVFL NDEAMRQEYV MNEHGTMYQG TKDFIKNIPW
NYGQFEDGVG ETCLRILDMS PSCLKDPATD CSKRGDPIFI CRVVSAMINS NDDRGVIESS
WDDLVRGGVE PSSWNGSVAI LRQWHTSGCR PVKYGQCWVF AGVLCTVMRF LGIPTRPVTN
FESAHDTNCT LTVDEYYDET GKQLETLGDT IWNFHVWNEC WMARKDLRSG YDGWQIVDST
PQEISGGTYC CGPAPVKAVK EGDMDVSYDV PFVYAEVNGD VIHWVVNEKG IKQGQVDTIA
IGKNFTTKRV GSNDKEDVTS HYKHAEGSPQ ERTVFAKATS AVKSKRPFSA KESGMASDFE
VSLKLAETPM IGQPIVLYCR ILNKSFAAKK LSVNMSAQAM QYNGTPLDQF WRKKFDVDVF
PNQATDGQFP IHPLQYQQFI RPGNSIRVTV LATDLQSKQF RFAAQNVVLK EPTIDIKIYG
TPQFNRPLNV QLSFQNPFNE VLTNCVMSAE GAGLLPNGPA EIYMGNIYSL RAGSVGLVCV
PIKRGKLQLE VSFSCNKVQH IKGSATIMVA AF
//
