ID L7N3K7_XENTR Unreviewed; 1604 AA.
AC L7N3K7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 1 {ECO:0000313|Ensembl:ENSXETP00000035969};
GN Name=trpm1 {ECO:0000313|Ensembl:ENSXETP00000035969};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000035969};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000035969}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000035969};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000035969}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2013) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSXETT00000035969; ENSXETP00000035969; ENSXETG00000016479.
DR AGR; Xenbase:XB-GENE-492528; -.
DR Xenbase; XB-GENE-492528; trpm1.
DR eggNOG; KOG3614; Eukaryota.
DR HOGENOM; CLU_001390_4_1_1; -.
DR Bgee; ENSXETG00000016479; Expressed in liver and 2 other cell types or tissues.
DR ExpressionAtlas; L7N3K7; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF13; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 852..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 949..967
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1008
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..358
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 857..1105
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1200..1255
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 428..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1508..1528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1546..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1604 AA; 181848 MW; 6370E523C1503BD4 CRC64;
GKGQKAWIEK TFSKRECIYV LANSKDSNRC CCGQLLTQHI PVPQNATGNK NGEECKQLEA
VPEKWSISKH TQLSPTDAFG ILEFQGGGHS NKAMYIRVSY DSKPDSLLHL MVKEWQLELP
KLLISVHGGL QNFEMQPKLK QVFGKGLIKA AMTTGAWIFT GGVSTGVIRH VGDALKDHSS
KSRGRICAIG IAPWGIVENK EDLIGKDVTK PYQTMSNPLS KLSVLNSSHT HFILADNGTL
GKYGAEVKLR RQLEKHISLQ KINTRLGQGV PVVALIVEGG PNVITIVLEC LREEPPVPVV
VCDGSGRASD IMSFAHKYSE EGGIISESLR DQLLVTIQKT FNYSRNQAHQ LLVVLMECMK
KKELITVFRM GSEGQQDIEM AILTALLKGT NASAPDQLSL ALAWNRVDIA RSQIFVFGHH
WPPLGSLTAA DGTTQDKDKK SPAAQPKATR GKGKGKKKGK GKEEPAEETD PRKIELLNWV
SSLEQAMMDA LVLDRVDFVK LLIENGVSMQ RFLTIPRLEE LYNTRLGPPN TLHYIVRDVK
KGNLPPDYHV SLIDIGLVLE YLMGGAYRCH YTRKTFRTLY NNLFGPKRPK ALKLLGMEDD
EPPTKGKKKK KKKEEEIDMD VDDPEVSRFK YPFHELMVWA VLLKRQKMAL FLWQRGEETM
AKALVACKLY KSMAHESSES ELVDDISQDL DNNSKDFGQL ALELLDQSYK HDEQVAMKLL
TYELKNWSNS TCLKLAVAAK HRDFIAHTCS QMLLTDMWMG RLRMRKNPGL KVIMGILFPP
TILFLEFRSQ DDLSFHTSKE YEEGKEKEDE NMDGNADTTS RKGDEENGNR KQKSIPIGTK
IYEFYNAPIV KFWFYTISYL AYLMLFNYVI LVKMERWPSV QEWVVISYIV TLALEKVREI
LMSEPGKLSQ KVKVWLQEYW NITDLVAISV FLIGAILRLQ NQPYMGYGRV IYCVDIIFWY
IRVLDIFGVN KYLGPYVMMI GKMMIDMLYF VIIMLVVLMS FGVARQAILH PDEEPSWRLA
RNIFYMPYWM IYGEVFADQI DLYAMEINPP CGENLYDEDG KRLPPCIPGA WLTPALMACY
LLVANILLVN LLIAVFNNTF FEVKSISNQV WKFQRYQLIM TFHDRPVLPP PMIIFSHLYI
ILKRICCRCK KIQEGDQDER DRGLKLFLND EELKKLYEFE EQCVEEYFQE KEDEQQSSND
ERIRVTSERV ENMSMRLEEV NEREHFMKAS LQTVDLRLSQ LEELSGRMVN ALERLAGIDK
SELINERSRA SSVCDAAFLL RQGSVNSSDG TSVYKYHVET DEVTCDESTG SISPALGLRR
KAYSFGMRTE KGEQDNKAQL VPRQASLRYA SSANAVATKD ANKVTLGIVS KSSRPISCVD
IWIPEFSKSE FANSHLTVER TKLEATISFP LERSKAMKYY SGQSFNTCQT TMTKSRSFVF
TEGGKLVGGV NNWTEYSTII DQVSPTSLEE WTDQWNNQGD SPRKQSPELA TIISEAEIQA
ELKPLLTDTE DDSDIGETGN SASYPCTERT ETKNLLSVQL DRTCGFSSPR SKSLHSHTGK
SRSLIDKLER PGHASSVMNI VVACGSVTED TKIKQENAST ETEC
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