ID L7QHA8_RVFV Unreviewed; 2092 AA.
AC L7QHA8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=RNA-directed RNA polymerase L {ECO:0000256|ARBA:ARBA00018602};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE AltName: Full=Large structural protein {ECO:0000256|ARBA:ARBA00030285};
DE AltName: Full=Replicase {ECO:0000256|ARBA:ARBA00031012};
DE AltName: Full=Transcriptase {ECO:0000256|ARBA:ARBA00030436};
OS Rift valley fever virus (RVFV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Ellioviricetes; Bunyavirales; Phenuiviridae; Phlebovirus;
OC Phlebovirus riftense.
OX NCBI_TaxID=11588 {ECO:0000313|EMBL:AGB13826.1, ECO:0000313|Proteomes:UP000157752};
OH NCBI_TaxID=7158; Aedes.
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=297284; Bos taurus x Bison bison (beefalo).
OH NCBI_TaxID=9837; Camelus bactrianus (Bactrian camel).
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
OH NCBI_TaxID=29031; Phlebotomus papatasi (Sandfly).
RN [1] {ECO:0000313|EMBL:AGB13826.1, ECO:0000313|Proteomes:UP000157752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sudan 2V-2007 {ECO:0000313|EMBL:AGB13826.1};
RX PubMed=23347790; DOI=10.3201/eid1902.120834;
RA Aradaib I.E., Erickson B.R., Elageb R.M., Khristova M.L., Carroll S.A.,
RA Elkhidir I.M., Karsany M.E., Karrar A.R.E., Elbashir M.I., Nichol S.T.;
RT "Rift valley Fever, Sudan, 2007 and 2010.";
RL Emerg. Infect. Dis. 19:246-253(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC compartment {ECO:0000256|ARBA:ARBA00004399}. Host Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004136}. Host endoplasmic reticulum-Golgi
CC intermediate compartment {ECO:0000256|ARBA:ARBA00004452}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the Bunyavirales RNA polymerase family.
CC {ECO:0000256|ARBA:ARBA00034123}.
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DR EMBL; JQ820483; AGB13826.1; -; Genomic_RNA.
DR Proteomes; UP000157752; Genome.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001882; F:nucleoside binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR InterPro; IPR022531; L_PA-C-like.
DR InterPro; IPR029124; L_protein_N.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR014385; RNA-dir_pol_phlebovirus.
DR InterPro; IPR007322; RNA_pol_bunyavir.
DR Pfam; PF04196; Bunya_RdRp; 1.
DR Pfam; PF12603; L_PA-C-like; 1.
DR Pfam; PF15518; L_protein_N; 1.
DR PIRSF; PIRSF000826; L_PhleboV; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 3: Inferred from homology;
KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 975..1166
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
SQ SEQUENCE 2092 AA; 238176 MW; E99C5D8D4EE83304 CRC64;
MDSILSKQLV DKTGFVRVPI KHYDCTMLTL ALPTFDVSKM VDRITIDFNL DNIQGASEIG
STLLPSMSID VEDMANFVHD FTFGHLADKT DRLLMREFPM MNDGFDHLSP DMIIKTTSGM
YNIVEFTTFR GDERGAFQAA MTKLAKYEVP CENRSQGRTV VLYVVSAYRH GVWSNLELED
SEAEEMVYRY RLALSVMDEL RTLFPELSST DEELGKTERE LLAMVSSIQI NWSVTESVFP
PFSREMFDKF RSSPPDSEYI TRIVSRCLIN SQEKLINNSF FAEGNDKVLR FSKNAEECSL
AIERALNQYR AEDNLRDLND HKSTVQLPPW LSYHDVDGKD LCPLQGLDIR GDHPMCNLWR
EVVTSANLEE IERMHDDAAA ELEFALSGVK DRPDERNRYH RVHLNMGSDD SVYIAALGVN
GKKHKADTLV QQMRDRSKQP FSPDHNVDHI SEFLSACSSD LWATDEDLYN PLSCDKELRL
AAQRIHQPSL SERGFNEIIT EHYKFMGSRI GSWCQMVSLI GAELSASVKQ HVKPNYFVIK
RLLGSGIFLL IKPTSSKSHI FVSFAIKRSC WAFDLSTSRV FKPYIDAGDL LVTDFVSYKL
SKLTNLCKCV SLMESSFSFW AEAFGIPSWN FVGDLFRSSD SAAMDASYMG KLSLLTLLED
KATTEELQTI ARYIIMEGFV SPPEIPKPHK MTSKFPKVLR SELQVYLLNC LCRTIQRIAG
EPFILKKKDG SISWGGMFNP FSGRPLLDMQ PLISCCYNGY FKNKEEETEP SSLSGMYKKI
IELEHLRPQS DDFLGYKDPE LPRMHEFSVS YLKEACNHAK LVLRSLYGQN FMEQIDNQII
RELSGLTLER LATLKATSNF NENWYVYKDV ADKNYTRDKL LVKMSKYASE GKSLAIQKFE
DCMRQIESQG CMHICLFKKQ QHGGLREIYV MGAEERIVQS VVETIARSIG KFFASDTLCN
PPNKVKIPET HGIRARKQCK GPVWTCATSD DARKWNQGHF VTKFALMLCE FTSPKWWPLI
IRGCSMFTRK RMMMNLNYLK ILDGHRELDI RDDFVMDLFK AYHGEAEVPW AFKGKTYLET
TTGMMQGILH YTSSLLHTIH QEYIRSLSFK IFNLKVAPEM SKSLVCDMMQ GSDDSSMLIS
FPADDEKVLT RCKVAAAICF RMKKELGVYL AIYPSEKSTA NTDFVMEYNS EFYFHTQHVR
PTIRWIAACC SLPEVETLVA RQEEASNLMT SVTEGGGSFS LAAMIQQAQC TLHYMLMGMG
VSELFLEYKK AVLKWNDPGL GFFLLDNPYA CGLGGFRFNL FKAITRTDLQ KLYAFFMKKV
KGSAARDWAD EDITIPETCS VSPGGALILS SSLKWGSRKK FQKLRDRLNI PENWIELINE
NPEVLYRAPR TGPEILLRIA EKVHSPGVVS SLSSGNAVCK VMASAVYFLS ATIFEDTGRP
EFNFLEDSKY SLLQKMAAYS GFHGFNDMEP EDILFLFPNI EELESLDSIV YNKGEIDIIP
RVNIRDATQT RVTIFNEQKT LRTSPEKLVS DKWFGTQKSR IGKTTFLAEW EKLKKIVKWL
EDTPEATLAH TPLNNHIQVR NFFARMESKP RTVRITGAPV KKRSGVSKIA MVIRDNFSRM
GHLRGVEDLA GFTRSVSAEI LKHFLFCILQ GPYSESYKLQ LIYRVLSSVS NVEIKESDGK
TKTNLIGILQ RFLDGDHVVP IIEEMGAGTV GGFIKRQQSK VVQNKVVYYG VGIWRGFMDG
YQVHLEIEND IGQPPRLRNV TTNCQSSPWD LSIPIRQWAE DMGVTNNQDY SSKSSRGARY
WMHSFRMQGP SKPFGCPVYI IKGDMSDVIR LRKEEVEMKV RGSTLNLYTK HHSHQDLHIL
SYTASDNDLS PGIFKSISDE GVAQALQLFE REPSNCWVRC ESVAPKFISA ILEICEGKRQ
IKGINRTRLS EIVRICSESS LRSKVGSMFS FVANVEEAHD VDYDALMDLM IEDAKNNTFS
HVVNCIELDV SGPYEMESFD TSDVNLFGPA HYKDISSLSM IAHPLMDKFV DYAISKMGRA
SVRKVLETGR CSSKDYDLSK VLFRTLQRPE ESIRIDDLEL YEETDVADDM LG
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