ID L7UAE1_MYXSD Unreviewed; 4805 AA.
AC L7UAE1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:AGC43404.1};
GN OrderedLocusNames=MYSTI_02075 {ECO:0000313|EMBL:AGC43404.1};
OS Myxococcus stipitatus (strain DSM 14675 / JCM 12634 / Mx s8).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=1278073 {ECO:0000313|EMBL:AGC43404.1, ECO:0000313|Proteomes:UP000011131};
RN [1] {ECO:0000313|EMBL:AGC43404.1, ECO:0000313|Proteomes:UP000011131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14675 / JCM 12634 / Mx s8
RC {ECO:0000313|Proteomes:UP000011131};
RX PubMed=23516218; DOI=10.1128/genomeA.00100-13;
RA Huntley S., Kneip S., Treuner-Lange A., Sogaard-Andersen L.;
RT "Complete genome sequence of Myxococcus stipitatus strain DSM 14675, a
RT fruiting myxobacterium.";
RL Genome Announc. 1:E0010013-E0010013(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP004025; AGC43404.1; -; Genomic_DNA.
DR STRING; 1278073.MYSTI_02075; -.
DR KEGG; msd:MYSTI_02075; -.
DR PATRIC; fig|1278073.3.peg.2113; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_11_3_7; -.
DR Proteomes; UP000011131; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 983..1057
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2054..2129
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3113..3187
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4696..4771
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 3280..3318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3299..3318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4805 AA; 529264 MW; BC8C49EEB4A2194C CRC64;
MTAESFVFPV SFAQQRLWFL HLLQPENPSY NIAGAVRLGG HLDVDALQRS FDALVERHES
LRTTFAQEDG NPVQVIAPEG RAPITRVDLC DAPEAEREEH ARRLATEECR RPFDLMRGPL
LRLRLFRLTP TEHLLVMTLH HIISDGGSLG ILVHEMSRLY DAFRAGREPD LEPLPLQYAD
YTQWQRDWLE TPGTLDAHLT YWKQKLAGAS VLQLPTDRPR PALQSQRGAA LPIHLPRPLV
EALRTLGQRE RATLFMAVLA AWQGLLSRYT HQTDIVVGAP QNNRANIQTE GLIGFFVNTL
VLRTDLSGNP TFRELLARVR EVLLEAHAHQ DLPFEQLMEQ VQPERNLSYT PLFQAALNLQ
AASPRELTLP GLTLKTVEFE TGTSKFDVTL DLQEGQDGLR GVLEYNTDLF DRATMERLRG
HLLSLLDGVT RAPDLRLDAW PLLTAPERHQ LLETWPALKP FPTEGSLPQR FEAQVRQRPD
AIAVVSEKER ITYAELDRRA NQLAHALRAR GVERETLVGL CVERSAATVV GILGILKAGA
AYVPLDPTYP ADRLAYMVTD SQMPVAITQR HLAERLPTDG VSLLVLEDAA EDLARQPTTS
PDVPISEAGL AYVIYTSGST GRPKGSLLPH GNVLRLFDAT EAWFHFDASD VWTLFHSYAF
DFSVWELWGA LLYGGRLVVV PYLTSRSPDA FLQLLHDERV TVLNQTPAAF RQLIQAEERL
ESKSLPLALR SVIFGGEALE PATLVPWFQR HGDARPQLVN MYGITETTVH VTYRPMTAAE
AAHTQQSPIG LAIPDLQLYV LDSRMEPVPI GVTGEIHVGG AGLARGYLGQ SGLTAQRFVP
HPFSHVPGAR LYRTGDLARF TPDGQLEYLG RIDDQVKIRG FRIELGEIQV VLSLHPAVRE
ALVLVREETP GARSLVAYLA TGDHAPPSVA DLRQFLLARL PDYMVPSAFV LMERFPLTAN
GKVDRKALPA PSRERAEPAR YVAPRNDAEA TLCAIWSEVL GVPRVGIQDN FFALGGDSIL
SIRVLTLARR KGLDFTLQQL FQHQTVAALM DAAGATREQP VREEFPRTEP FSLLTEEDRA
KLPPGIEDAY PLARIQAGML YHMQLAPDSN VYHNTDTFHL RLQTPVDTVM FEEAMRVVVA
RHPVLRTSFD MTTYSEPLQL VHREATLSMK VVDLRHLSDA EQEAAIRQLL VDERHTPFDL
AVPPLLRFFI HLRGEQSFQF TLTECHAIID GWSLHSTLVE IFNHHHALVN GQTPPPELPA
TMTYRDFVAM ERRVIESEPH QRFWRDQLAG GSVMRLPRWR RAPASETPRI ATVKVPLSRE
VHDGLLALTR AEGVPFKSIL VAAHLKVMGL MSGQDDVITG MGVNSRPEEG DGSRLRAIFL
NTLPFRLRLA PGSWTSLVRA AFDAERALYP FRRFPMADIQ RQWGREPLYE VMFNYMHFHV
LHELAGTLSQ VETLGMIRAE GTNATLAVHF QTEPHTQELT LELDYNAVEL EHVQVEQVGA
AFQRVLSALA FHADQPHHTT SALPPEEQRR LLVDWNATAA PFSTDATFRA LFEARALAHP
DAVAAVEGTR TLTYGELDAR ANQVAWQLRS MGVGPERLVA LHLDRSLELL IGLLAATKAG
AGWLPLDPAY PSERRAFMLS DSRAEVLLTT SHFAPELSSV GLRTVLLDGP RDAHPGLATG
ALPPTPNGDA LAYVIYTSGS TGLPKGTLVT QRGLVHYLDW ARREYQVTQG QSAPVHTSIA
FDATLTSLLT PLCAGGTVHL LPSGQELEAL AVSLREHRHG LVKLTPAHLQ VLSNLLPEQA
LASLEGTFVV GGEALPAATV ELWRRQAPRV RLVNEYGPTE TVVGCSIHDV SATGLVDGVV
PIGRPIANTE MYVLDAQLQP VPVGVVGELY IGGVGVARGY LGRADLTAER FVPDPFSGRT
GARMYRPGDL ARFLPDGAME FLGRRDGQVK LRGHRIELGE IEATLRQHPS IGDAVVLVRE
DVPGDQRLAA YVVPHAGMAA DAGDVRAFLQ QRLPGYMVPA SFTSMETLPL TPNGKVDRKA
LAAPMSAASG AALAPRSGTE ELVASIWASV LRTERFGLHD AFFDLGGHSL LATQVVSRVR
EAFGLELPIA TLFEAPTVAG LSERIQALRA KAMGEPPPPP LRTAPHEGPQ PLSFAQQRLW
FLYRMEPESP VYNMPAVLRL SGALDADVAR RCLDALRARH ESLRTTFLMH GQTPAQVVAP
VADVPLEVID LTGLPVEQRE AEARRRVDEE ARRPFALERS PGFRCALVRL GEHEHLLLLT
LHHIIADGWS LSVLVREVAA LYASFSAGQP SALSPLPVQY ADYARWQREW LSGAALERQL
SYWKERLAGA PPFLELPADH PRPPVQGFRG TTHQGPLLAR EEAEALRALC RREGATPFMA
VMAAFQVLLH RYTGETDLVV GTDIANRNHL GTEGLIGFFI NQLVMRGDLS GDPTFRALLR
QTRRTALEAY AHQDLPFEEL VKAVNPERSV GYSPVFQVKL ILQNAPGSDL ELPGLVLKEE
ASTTNTARFD MTWVVTETEH GLECLCEYST DLYARETIAR MREHLGQVLA SAVARPEEHV
SRLALLPEAE RHRLLVEWND TAVSLPEEAL AHRLFEAQVA RTPDAVAVSF EGRELRYREL
DARANQLAGH LRGLGVGPEV RVGLCLERSP ELVVGLLAIL KAGGAWLPLD PTLPMARLGL
MMRDAGVPVV ITQEHLADEL PIQAELLVCL DSEADAKHIA RQPVVPPSVA LSPDHLAYVI
FTSGSTGKPK GTLLTHRGLC NTALAAVRAH RIQPDSRVLQ FAAISFDASV CEVFSALLAG
ARLCLAPRDA LMPGAPLQGL LVSQGITVAT LTPSVLARLD PAGLPGLASV ISAGEACTPE
LARQWVVGRH FVNAYGPTEV TVCASAREQV DAERPDIGRA WPNVRLYVLD AEGRPVPTGV
PGELFIGGVG VARGYLGRPE LTAERFVPDA LSGTQGARLY RTGDRVRWLA DGHLEFLGRT
DFQVKLRGFR IELGEVEAAL AELPEVREAA VAVREEAPGR RQLVAWIVPV DEEAPDTAAL
RRALEARLPD YMVPSAFISL KALPLTSSGK VDRRALASEV QQQPQRAQDT YVAPRTAVER
TLTAIWSAVL SRERVGIHDN FFELGGDSIV SIQVIARAQE AGLRITPRQF FQHQTIAALA
PHVSEAQAPR GEQGVVTGPV PLTPIQQWFF ESRRPEPHHY NQSLLLGLRE RPSQEALRDA
LTALVAHHDA LRLRFEETPN GWRQENAALA DATRTCAATS YTAPGAHPPP DKAHASQAAA
TAQPPSDAAH ASEQQTSGTV IPTAPAHAVE LRGVDLSALD AAAQREALEA EARKVQAGFD
LTRAPLMAAV LFDLGPRGTR LLLAVHHLVV DAVSWRVLLQ DLGTAYQQLL RGDAVSLPAK
TTSFQEWARR LEALAQGPEL AEEAATWLRQ GLDVPPLPLD LPGGDNTLAS ARTVSVALAT
EETRALLHEL PKSYRARIDE VLLTALVRAL SAWTGHRLHR VQWEGHGREE LFEDVDLSRT
VGWFTSIYPV TVELPPVGTP GDGLRAVRDA LRRIPRKGLG HGLLRYLRQD SLRTKLEASP
EPQVAFNYLG QLDSALPSDS PLVPADEPIG AQQSHLGLRR QVLEVNAHVL EGRLEVSLTY
SEALHHRSTL EALAQGYLHA LRELMAGQDT EDAKRLSPSD FPLADVTQAT LDTLLRDHPG
LEDLYPLSPM QQGMLFHARL EPRAGVYFER AAWTLDTDLN AEALRLAWRE TMERHPILRT
SFAWEGMEEP HQLVHGEARL PWEEADWRGL SADPRKARQA QWMQEDEARG FDLERAPLMR
VAVLRLGERT WRVVWSFHHL LLDGWSVGRV LNEVLARYDA KLRRETPTLE APPLFRDYIA
WLRERGTAKA ETWWRQELAG FTEPTPVPCE QGGQARSATP VMGARKVLVP EDATERLRVF
SRRHQVTLGT LVQAAWALVL GRHASSEDVL FGVTVAGRPP ELGGVEQMVG LFINTVPARV
RLPASKRVVD WLKELQAAQV ERAPHESAPL VRVQGWSQVP RGTSLFETLL VFENYPVEQS
VMQGSSALEV RDVNAQERTH YPLTLTAHAD KELLLLIDFE SPRLDERAVE QLLEQLATAL
VNLCASETRA LGDVSILTEA ARHRLLVDWN DTHAPLAADA CVHEHFEAQA RKTPDAVAVS
APGGASLTYG QLEEQSNRLA HHLRARGVGP EVLVGVYLER TPELYVALLG ILKAGGAYVP
LDPAYPSERV ALMVSEARLS WLITQRTLEA SLGPSDVPRY LMDGEAPARE RLPTVPPPRL
AGSGTLAYVV FTSGSTGTPK GVMVSHRSWA NAYLGWEQGY GLRDEGCRNH LQMASFSFDV
FAGDLVRALL SGGRLVLCPR EWLLEPARLY ALLRDEDIHC AEFVPAVARG LLQHLEETGQ
RLDRMRAFVA GSDAWYVDEY HRLRGVIGDG TRLINSYGIS ETTIDSTWFE SDGLTGAESR
LVPIGRPFAN VRVHVLDARH QPVPVGVVGE LFIAGEGVAR GYRLRPELTA ERFVPDPFGA
PGSRLYRSGD RARWLPDGNL EFLGRADTQV KLRGFRVELA EIESVLGKAP SIESAVVLLR
QDPGTPARLV AYVVGAGGQD VSALRDFVRA RLPDYMVPAL FLRMEALPLT PNGKVDRRAL
PVPDAGLRAV DDPLVAPRTE TEAALLAIWR EVLGLESLGV MDDFFAVGGH SLLATRILSR
ANAAFEVDLP LRALFEHTTV AGLAERIILA RLEAVDEAAL ASLLDEVDGL SDEEAALLAE
GSHNE
//
