ID L8FM79_PSED2 Unreviewed; 842 AA.
AC L8FM79;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=XPG-I domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_05194 {ECO:0000313|EMBL:ELR02032.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR02032.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL573274; ELR02032.1; -; Genomic_DNA.
DR RefSeq; XP_012743622.1; XM_012888168.1.
DR AlphaFoldDB; L8FM79; -.
DR STRING; 658429.L8FM79; -.
DR VEuPathDB; FungiDB:GMDG_05194; -.
DR HOGENOM; CLU_007575_0_0_1; -.
DR InParanoid; L8FM79; -.
DR OrthoDB; 1779469at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0008821; F:crossover junction DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR CDD; cd09906; H3TH_YEN1; 1.
DR CDD; cd09870; PIN_YEN1; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041177; GEN1_C.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR InterPro; IPR037316; Yen1_H3TH.
DR PANTHER; PTHR11081:SF71; ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF18380; GEN1_C; 1.
DR Pfam; PF00867; XPG_I; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064}.
FT DOMAIN 1..95
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 111..185
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 482..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 92983 MW; 3B64780562491627 CRC64;
MGIPGIYNEI GPGQRVSLTK LAVEKFEQTG RPFRIAVDIS IWNFEVQGGK GGPNPALRTL
FYRLVRLAGT SVQAIFVFDG PDRPLLKRNK TRRKGGSAYL ADVRRTKLLL QLFGFESHDA
PGEAEAECAL LQQRGLVDAV LSEDVDTLMF GSGITIRDWS CEGSGKTPPT HVSLYDAKVT
KEGKSGLDRE GMILVALMSG GDYDTAGVAR CGAKIACEAA RAGYGKSLCD LAPDDSPGLL
AWRENLVHEL HTNEGGYFRQ KNKAITVPDD FPKEEILQYY MHPIVSSEAA LLNLRSRLQW
DREIDSKRLR IFVEECFEWT GKLSGKRLIR LLALPMLIYK LRERPKSVDS GHGNLVLIEA
QEREIVQEIT GERQHFSTDG ILELRLTFEP FGIVGLDIEA EIDDESNPDQ QDEYLAVDEE
NLEVYQSDNE PTGKSRSMSP MKNRLAVYDP TKPSKTWVSR SIARVGVPLK VEDYEESLML
KQSRANAPKR KAAPKATKHG MKQGALDRYF VTSKPVATGA ALSSESPNKK SDHQPQLPPV
YLAPSLDKPP LQPKGTTKEP LRPRREYRKA PSGDRYCQVS PKPSNPWAAT QFRSSQPVSA
NVSKSGISQS NKGGSSQASS SLASQMISSY DISSSRNLFP KKHSRNGSPP LYVSSISDAE
IPTGSVPLPS VKKRTAVTGD QGYSGTSRTT QSDAPTSSLQ ISRKLDIDLG DQYLPTLSDE
EYDALPPLDY LLSPLQTNTF STEDNKGTQN AIDLMSSSPL SHYTTTKQAE SPLAMGKPSS
HADVLSFADS KVPQKRFLAP RESLPGAWKK YTEKEVEDME RKGRGRQKWR VSQVEALDLT
QD
//
