ID L8FYE5_PSED2 Unreviewed; 897 AA.
AC L8FYE5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=GMDG_07479 {ECO:0000313|EMBL:ELR05559.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR05559.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
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DR EMBL; GL573396; ELR05559.1; -; Genomic_DNA.
DR RefSeq; XP_012745932.1; XM_012890478.1.
DR AlphaFoldDB; L8FYE5; -.
DR STRING; 658429.L8FYE5; -.
DR VEuPathDB; FungiDB:GMDG_07479; -.
DR HOGENOM; CLU_007903_0_0_1; -.
DR InParanoid; L8FYE5; -.
DR OrthoDB; 203742at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR039331; PPA-like.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR PANTHER; PTHR22953; ACID PHOSPHATASE RELATED; 1.
DR PANTHER; PTHR22953:SF159; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361203};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT CHAIN 20..897
FT /note="Purple acid phosphatase"
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT /id="PRO_5005139256"
FT DOMAIN 79..174
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 286..505
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 536..597
FT /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
FT REGION 644..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 95564 MW; 9AB3949FF7B07C7D CRC64;
MKTTTALFVL GALSTATNAV PAPVVDTVYP YTGPDVPIGD WVDPTINGNG KGYQRLVEPP
AVKPASENPT NNVNVISLAY LPDGMNIHYQ TPFSLGVAPS VKWGTDPNKL YKTATGNSHT
YDRTPPCSLI SSVTLCSQWF HEVPIKNLQP GTTYYYQIPA ANGTTVSDVE KFTTARAAGQ
EGEFSVAVLN DMGYTNAGGT LTQMSLAVDD GVAFAWHGGD ISYADDWYSG IIPCESSWPL
CYNGSSSQFP GGVVDNPDYL EPLPEGEVPT QGSPRGGDMS SLYESNWDLW QQWANTITTK
VPYMVLPGNH EAACAEFDGG HHELSAYLND NKANSTGNST NYLTYYSCPE SQRNFTAYMN
RFKMPGDETG GVGNFWYSFD YGLAHFVSID GETDYAYSPE WPFVRDLKNG ESHPLKTETY
PTDSGPFGRI DGTWQDNTGY EQYQWLAKDL ASVNRTKTPW VIAMSHRPMW SSSTSSYQTY
IRAAFQNLML QNGVDAYLSG HIHYYERMYP LTSTGAVDSG SVINQNTYRT NPGVSMTHII
NGMAGNIESH SILSGKIQPK TAVLDMTHYG FNKLTFFNST AMKFAFVLGK DGSIADEVTL
LKPNANVSST STSASATATT SGLTTLTSGT STKTCILRIS STTIGTASTS GPSSPNTVDS
STTDTSPPTT VHSSTTETSS PTAVDSSASE TLSGATDTAS SYTSSTVYTT VTSIISSCKP
TVTNCPYTTA PITVTDTIIG YTTYCPVSGS PTGTVLQTIH AQAATSDVPY TTSTVYKTTT
STISSCAATV VDCPYTTVPF VATVVVVDYT TYCPVATASA TTPKGSVEAV PVATSSATTP
KGSVEAVPVV GGSAATAKGS VETVPVVGGS TTTPKGTVFS MLWQCFQLIV DRRNIAN
//
