ID L8FYZ2_PSED2 Unreviewed; 774 AA.
AC L8FYZ2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_07536 {ECO:0000313|EMBL:ELR05693.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR05693.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL573402; ELR05693.1; -; Genomic_DNA.
DR RefSeq; XP_012745989.1; XM_012890535.1.
DR AlphaFoldDB; L8FYZ2; -.
DR STRING; 658429.L8FYZ2; -.
DR VEuPathDB; FungiDB:GMDG_07536; -.
DR HOGENOM; CLU_011310_3_0_1; -.
DR InParanoid; L8FYZ2; -.
DR OrthoDB; 248389at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF100; PROTEIN MAM3; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..268
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 287..349
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 353..414
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 453..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 83050 MW; F20E1D87B72CCDF6 CRC64;
MGLVRGKRAT PAIEPTLFKL LASTMTIRSH NPRYNVSPGG TRPAVVSLAK VLFLAASQMS
VAGAAPLTSW IKGIEDMPKS PEDPGLWLYL TAAFILVISG GAFAGLTIAL MGQDGIYLQV
IATSGEGKEQ KHAQRVFKLL KRGKHWVLVT LLLANVIVNE TLPIVLDRSL GGGWPAVLGS
TALIVIFGEV IPQSICVRYG LQIGSVMSPF VLVLMYLLAP IAWPTAKLLD HLLGEHHGTV
YKKSGLKTLV TLHKTLGSTP GDRLNQDEVT IISAVLDLKD KAVGDIMTPM GDVFTMSVDT
VLDEETMDAI LTAGYSRIPI YEPGNENNFI GMLLVKMLIT YDPEDCKKVG EFALATLPET
SPETSCLDIV NFFQEGKSHM VLVSEYPGED HGAIGVVTLE DVIEELIGEE IIDESDVYID
VHKAIRRLAP APTYRRAARG QVVADSDIPK LQSLQGSPVV GADENSKGSS SGRRQLSLDG
KAPGQSPVTF GTSPKATFMI RRSSAAADGG SVTVRGNATD MREHLKHLGP SNLASRPKTT
RYSTVKIKPG LVKDTKDHPT SVHEDLVVFE DDSEMYSAPY GGEGEGLLQS AGRPASDGVL
ALQQGYGSID HGPTHRTSSP LWAHKLQQAD INEPDKSQST EGLPSKGSPP RRPELHESDS
GGTISSLRSG LASPAPRKRG TARSGSITEN IGVRKVVLQT TSSSDGDDAL YSQHDEDGAK
NTRETNVQLV EPQPAEEAAS DGQAEVDDVK KKTKRRRKRK NHKDADGDGP SQDA
//
