ID L8G626_PSED2 Unreviewed; 679 AA.
AC L8G626;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 13-SEP-2023, entry version 35.
DE RecName: Full=Heat shock 70 kDa protein 12A {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_03262 {ECO:0000313|EMBL:ELR08567.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR08567.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL573219; ELR08567.1; -; Genomic_DNA.
DR RefSeq; XP_012741676.1; XM_012886222.1.
DR AlphaFoldDB; L8G626; -.
DR STRING; 658429.L8G626; -.
DR VEuPathDB; FungiDB:GMDG_03262; -.
DR HOGENOM; CLU_009958_6_1_1; -.
DR InParanoid; L8G626; -.
DR OrthoDB; 1377857at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10229; HSPA12_like_NBD; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR14187; ALPHA KINASE/ELONGATION FACTOR 2 KINASE; 1.
DR PANTHER; PTHR14187:SF5; FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064}.
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 74227 MW; F8B2614DC1D9E57C CRC64;
MNIDLPLRPA NGRGDSNNSI INSNSATSSG IGSVGDRARP FFASSSPSTT AAAGANIGGG
NGAPQYRMPV RTSAQSEAEA IAGPVREVAP MNDRLIVGVD FGTTYSGVAT VYTSTPDDVE
IIKTWPGGNG ITSDKVPTEI SYVALRSATE SGEDTIKPRW GFMFKPEEPR LRCMKLFLDR
SQKLPFYVSP KETATQLKKH NKTVVDAVSD YLTEIYKHTM DTLARRYGDA FMSTTKVEFV
LTCPAVWSDA AKNTTLLAAE KAGMGSKEEI QMISEPEAAA VYALKTIQPN HLSVGDNFVV
CDAGGGTVDL IAYKIMSLKP LRVEESAVGT GGLCGSAFLN YRFEEHVRER VGAAAFDEMK
AKKQKTWQMG LKYFEEFVKR NFNEEEHGEV NIPFPGLPDD EEAGIDCGFL VMTAAQVKDI
FEPVVKEVCD LVQGQVSGIR AKGGIVSGIV LVGGFGQSDY LYKRLKANFN TTAPPPYSER
PTHAQANDMV NNGSVEVMQP VYAWTAVVRG AVLRGLEGSM VVSRKSRYHY GTSYATVYDE
DKHAVGERYW SPLWERWMVS DRMQWHISKG EDLSPITPIS FHYTRNFRPG QSLIVSDDLI
ACDETTPPGA YSRDLINVCT LTTDLGAVPK SLFTRLTTTR GVEFDNLDFT LEMVVGSAGL
GFMLEVDGVR YGSVVAEFH
//
