ID L8G926_PSED2 Unreviewed; 2598 AA.
AC L8G926;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=GMDG_03703 {ECO:0000313|EMBL:ELR09123.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR09123.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL573230; ELR09123.1; -; Genomic_DNA.
DR RefSeq; XP_012742120.1; XM_012886666.1.
DR STRING; 658429.L8G926; -.
DR VEuPathDB; FungiDB:GMDG_03703; -.
DR HOGENOM; CLU_000249_0_2_1; -.
DR InParanoid; L8G926; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064}.
FT DOMAIN 1233..1426
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 117..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2598 AA; 289449 MW; DE66522B2BBDAA04 CRC64;
MAANGDLNLV ASLVDRLATR LPHRTGSSFR DLRSDDLVSL TRATLIEVSS TYLSTAAASL
VLLLEELSAQ YKDLDTHPPH VVNSELYIIH ILADCFSAHW DAVNRVPNYQ TKNADWHSIP
RSGRVDSHSG TDEEESTQES ATRRLVLPKP LDDILAGRVL EAVKIFLAPY PEQYTLPAST
ILEYSNCRLA QNIPCRLDNS DAENNSFGKG PGLYSTDGTL QNIEAHTRTI IEFLSASNWD
LFFGHLKTSF RLLQVVYPLQ GNGTQAAPVL DDDRNALATL RIVAFIWVDK RKLSLVLSEL
CSCFFHLRKT FQSTLGLALP ILILRWVEQN PEEFVLMHNS HSKIDGVDRL FDIANGMVDS
NRWKAVLYPF QFFLFFLIPD VFEVATSVPS TGRYLENGSL PKASSGIFKK VSFLESLRKA
LRNKNPAAAY CLISLLRIAR HFSLEGNDSA LLSYALDVQE EVRDALFRKN IVGSEGAIFD
NGLMTAAFVS LTHLNFESCN ENIAPQCLSS NAPNDFKLAF VSACSNLAKL PNAHLYTELF
EKTTGLIRDH LKDHSHEPYG APKSSSNIAE MTYRCLDFLN VLPLTLFGGA PSNPVDYEVF
FQENFAILVG CLVDEDPKVR RMAGSVTRKL LKNGSVFLLH KGASKDAGFF PANFWRSTSA
VLLNVLEHAA KLGRRGDSVL SFIHDFVESR VELIRSAKDD LISQAETPQR LASLSKLETY
FLVRLCSADI EICQIVTVCV GLLCEETQMV DAAYDSSKSP STIMRNIEVY QDLSSRDFHF
TGLVAFQKRL RSLLRQMRHP SAAVLSAWEI VFGRWYDLSK RASTHRQDET LDERSLVEWR
NCSGFLASLA ALCISKQTYS VIEESGLAGL KWIDRPSQDS YDNTLLDRYM TQSVQLLACS
NARIREAMRE VLSTEISPSL YLPLFKTLES ELETLFDGPI DTANRFSDSR IAFAEHAAAL
LKTIIERLGS PADMGAALSV DIGALTLNFA RFLNSVSEGL HTLRIKIKVC QLCEVVTRKK
ELLNLRHDLR IRNQLLEIMF GWIARPGSPK ADNAAMVDGI HRDDALKLQR DLYRSCLKAL
SDLTFRLPLQ PPDGQTDADT SDLKSEMFHT YFNRFLSLLS FEPTDQGKND VASNLSAKED
SLSIRELAII ALSNLLGANI DVGLKHSLGI GYHEDLEIRT AFVTVLCNVL AQGTEFNNLS
DVAVGEKYDE LVEVLVNDMT LTIALCDACP SNEVDELTMS LLNIFDSRGL GFILLEELIK
HEVDNTENEA ELLRRNCVTT KILSVYARWK GSSYLKSTLQ KVLERLIVTA QDLDLELDPS
RTSSPEELQR NTLQLRVVAK VFIDDICSSA PNIPISFRNI CSIISSSVMT RFPDAKFTAV
GAFIFLRFFC PAIVAPDVEG LISTAPSKEM RRGLLLIAKI IQNLANNVLF GAKESYMFPL
NDFLTQNIYE VTAFLRTISV APHVETTGIE TESFDFGSCV ALHRFFYDHW DHVRQKLVAQ
QRKGSLHPPH EIAQGRLPVT EALRNLISNL GPPPMDISWN RPMISMNSPP SYSRFQHFML
SHAGRSTESA ISTRTVYDGG ESKDGLSMIC IILRNIDAET NNYDLLVYCY LKIASRMWHR
PFGVMIDATC YSGQNEPQDA LFKKLDLLTP TELSKNLTCV YVYNMNSTFR KCFRRILRLS
AKNENSAFHP KSVDYHLIGS LQDLQTHFHL GQLHLPKETI SVITDTRFVF QPVTRLSKTK
GKIEVMIQVG SQFVQVTTTK KQEIVPGLRL HATVNDIFRL TEVDEAPTSI QTEDDSAFGL
RADSGKIVMY FTSPRKSDVL QAIRGAKIKY SKDLKPSQPF ERLIRPQDIP GTLLNISFTN
LASLDQNLRI AAYNLLCALC QTFKFGVNSS FMASKELSIP PSASHFIVNV SRQLAASEPQ
LTADFMNEFF VGWESFPLQQ RPLSLAYLSP WLSGLRSQVL AVEIDGEKAR ERIASIFRKL
IDVTVPDSTL CITLEQIIWP VICEDDVLTD ILVDEIIKSA LTSSNNESRI SRLGSIIASL
QVVTVRGKLI SRLRKALNRT SLRPTRLLPE NSVWDEICIL LRLCLAASFN SGVQAHLYLP
EISHIITMLA NTGPAQIRLV VHGLLVNTVH ILCTCFSTDE SKLVRLKVIL ASLSDPNTAH
QANLSGVTRE GTTISHAQDP TWQILSSTEA LAVLLSEVSS LAASSVDLSN AWRSRWMSLV
ASTAFQSNPV IQPRAFAVMG CLAREDVDDD LLYQVLVALR KSVNRFADEN DNEMLVSIVT
SLTKMMEKLP TTSRYGLQLF WLAMALVRLV PLNLFSCAAS FLEAVLININ TSGDLKGGRM
VPVLLQGRLA LEDSASQLDE SYGIHFNIDN FHFAVCASLV KGLTDTVTKA TTVKVLSTFL
EIASSSAVGG RKFPDDLSCL PYLGLVMSRA LTTEEAKGNL WLAGINGDKS STPEDVLAMI
NLDTIKDKEL LLNTAINLVD FRYLEDSVQN RGLVWMNKVA IIRPTVILHL SCPILSILDE
VLLSSQNFVT LKSAQMLLRT LTTNPKLSDT VDAAQLLEDV LEDIGFGGLW VSSTFHNSAE
RDGHCTVLTD KLIELIIT
//
