ID L8GAF5_PSED2 Unreviewed; 4352 AA.
AC L8GAF5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=GMDG_04101 {ECO:0000313|EMBL:ELR09608.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR09608.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; GL573239; ELR09608.1; -; Genomic_DNA.
DR RefSeq; XP_012742521.1; XM_012887067.1.
DR STRING; 658429.L8GAF5; -.
DR VEuPathDB; FungiDB:GMDG_04101; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; L8GAF5; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064}.
FT DOMAIN 1928..2066
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2220..2457
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2585..2735
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2927..3093
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3189..3223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3422..3456
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4352 AA; 492409 MW; E58C9B1DAD657915 CRC64;
MVTLVSSPAS PSANGVAGSH FSTVDPTVVV EHLARLIEAN LGATRRELES IGSLLSKSRY
PETVQRCTRF ATESQVALYV QKDIVGTEED AKQSSDGQGG FAYTLTGDPT LSPLTITSLI
VTKRSPAIDP SIPVALQIHS IVLPGAAAQT TTTGGSGPTI EVLYNLIHNG LGPFFDAYIK
NQAAASGNSG RTEVDSKTGI QVTKKRIADL DLSLRHLQEN VEIPELSLPL HPLVQNAADE
AAARGAKPTV DYISESILQD STFLNSLQTT VNNWIKSIQT ITKMTRDAKT GTANQEIDFW
LSKESALESI EAQLRSDGVQ LTLEILRHAK RFQATVSFTA DTGLKEATEI VQKYNQLMRD
FPLDELNSAT ALSKVVEAIG QIFNHLNKKL RICPYPVPRT LSLVEAISAD LDTKLHSLLH
GRSLMHLDYR DFKVLMTTAD SIFAAWDESI KEFTNVAREV TRRRNDKFIP IKINSRHAAL
QQRLKYVNTF RDNHEQLQRT IINVLGPNSN GGGVDAGSAN GVVLIEEMGD VDAVEEVQQA
YAALKNVDLL DTSPEGTQFW AQQETAYNER TARVENSIIA RLRDRLATAN SANEKFRVFS
KFNALFVRPK IRSAIAEYQT VLINNVKTDI TALHERFKQQ YGHSEAHAMA QLRDLPPVAG
AIIWARQIER QLDGYMEKVE NVLGHDWALH AEGQKLQTES NMFRKKLDTR PIFEAWLHDV
QRRQINITGL LFAINKNRSA GNALELAVNF NPQVIALFKE TRNLVWQGYQ VPHAINNISK
EAKRVYPYAV SLMESVRTLA QTNRQISEMS DVSTLLSGYQ NDVQALIAKG LPLKWESFIH
SYDVHIKQTY LPNGTMDHNS GNRNESKHVQ FVREFGVTVS LLQNKTEVLA SINTTVQRAL
ADIETCPYNE TTFQERLETI QMAVDQLNLE NFVNLDHWVH GMNQRIENTL LGRLHQAIKT
WIEAFQDVQS ETVDSDSRRR LKTDPNDVSI SSLPVIRQLV HEITMRNQVI YLEPPLEYAR
ANWVSELHGW LGVVCNLRKI KASRYQMSIA ASSEAEARFT DLPRNCADSL LEVYTTIENQ
LLEISRYVDK WLQFQSLWDL QSGQVYEILG DQLSKWLQLL REIRKTRSTF DTTEVSRSFG
HVTIDYDQVQ TKVNAKYDQW QHEILTKFAG RLGTRVREVH SEIEKARKDL EVQSLEASST
AQAVQFITIV QACKRKVKTW GPEIEIFRQG HTTLVRERYQ FPADWRSNEQ VDSEWDALNE
LLNRKSKTVQ DQTDALRAKI VAEDRLVGEK IAEIIVQWNE EKPVSGTIAP GVASSTLTSF
ETRITKLHEE SLMVSRAKEA LDIPGSPDAA LAAILEEVQD FKGVWAALST IWKSLNDLRD
TLWNSVQPRK LRTLIDGLIK MTKDMPSRMR QYAAFEHIQN ILRKLLKANS LLAEMKSEAV
RDRHWNKIYK SLRPGKRYSP ISMTLGDVWD LNLAASEVVI RDIIAQAQGE MALEEFLKQV
REIWTNYSLD LVAYQNKCKL IRGWDDLFAK CSENLNSLQA MRHSPYYKEF EEEAASWEDK
LNRVHVLFDV WIDVQRQWVY LEGVFTGNAD IKHLLPVESN RFQNINTEFF SVMKKVYKVP
FVLDVLNIPE VQKSLERLAD LLNKIQKALG EYLERERVSF PRFYFVGDED LLEIIGNSND
TLRIAKHFKK MFAGLSGLIM DQDAIISGFT SREGEEVRLK KEISLVKTPK INDWLALLES
SMKSTLAELL AEAYTEFHSL FTAEDVDSTL LNEYIKKFPA QIVVLATQAV WTNAVEASLQ
AGGSTLQTLY DQEVKVLRLL ATTVLGDLDP IERKKCEHLI TECVHQRDVI EKLVRLNATT
QTHYMWLLQM RYVYQPEGDF LNRISINMAN AKLSYGFEYL GVAERLVRTP LTDRCFLTLT
QALSQRLGGS PYGPAGTGKT ESVKALGVQL GRFTLVFCCD DTFDFQAMGR IFLGICQVGA
WGCFDEFNRL EERILSAVSQ QVQNIQLGLK QGVEDEKSQI ELVGRQLRVN ANTGIFITMN
PGYAGRSNLP DNLKKLFRSV AMSKPDKELI AEVMLYSQGF NQAKQLSKQT VPFFDRCGAK
LSKQAHYDFG LRALKSVLVS SGGLKRARLT VSGGDLGPEE EVEPQIIVQS IRETIAPKLI
KSDVEIMRAI EEESFPGVKY IPAALEELKA SMQSIAAERN LVVNDTWMTK ILQLFQIQTI
HHGVMMVGNS GSGKTAAWKV LLQALQQVEG VEGVCHVIDS KVMSKEALYG NLDSTTREWT
DGLFTSILRK IVDNLRGEET KRHWIVFDGD VDPEWVENLN SVLDDNKLLT LPNGERLNLP
SNVRIMFEVE TLKYATLATV SRCGMVWFSE DTVTPTMMVD NYLGKLRKVA LEDLDEDSVA
TGQTTAKALA IQEEVSDLLQ SYLKTEDFLL TALEHAENFK HIMEFTVARV LNTLFSLLNK
TVRDIVEYNA QHVDFPLDSD QVESFVSKKL LLSLVWSLTG DCPLGDRKVF GDYVATLSTF
GSPLLEGNSS LIDFDVTLPQ AQWVSWQNQV PTIEVNTHSI TQTDVVIPTL DTVRHEDVLY
SWLAEHKPLL LCGPPGSGKT MTLFSALRKL PNMEVVGLNF SSATTPDLLI KTFEQYCEYK
KTLNGVILSP TQIGRWLVLF CDEINLPSPD KYGTQRAISF LRQLVEQNGF WRTSDKTWVT
LDRIQFVGAC NPPTDAGRTP MGARFLRHAP LIMVDYPGQQ SLKQIYGTFT SAVLKIVPSL
RGYSEALTNA MVQFYIESQE RFTPKIQPHY VYSPRELTRW VRGIYEAIRP LDTLSVEGLV
RIWAHEALRL FQDRLVSEDE RKWTDDAVRR NALEFFPMMD ETKALAGPIL YSNWLSKNYV
PVDREQLREF VKARLKTFCE EEVDVPLILF NDVLEHVLRI DRVFRQPQGH LILIGVSGSG
KTTLSRFVAW MNGLRVFQIK VHGKYSAEDF DDDLRDVLRR SGCKGEKICF IMDEANVLDS
GFLERMNTLL ANAEVPGLFE GDELASLMTA CKEGAQRQGL LLDSQEELYK WFTQQIIKNL
HVVFTMNPPE DGLSSKAATS PALFNRCVLN WFGDWSDQAL FQVGSELTHS VDLDRPNYTP
SDSIPVAYRE LSLPASHRDA VVNAMVYIHY SLQRFNLKLL KQQSRVTFLT PRHFLDFVAQ
YVKLYNEKRE DLEDQQRHLN VGLEKLRDTV DKVRDLRISL AEKTGQLERK DAEANEKLQR
MIADQRLAEQ RKTTSLEIQS ALEKQEVAVA ERRELVLNDL ANAEPAVIEA QKSVSNIKKQ
HLTEVRSMSN PPRGVKLALD SVCTLLGHRI DSWKTVQGII RRDDFIASIV NYDNEKQMTK
NLRVKMRNDF LSKEDFTYEK VSHASKACGP LVQWVEAQVN YSEILDRVGP LREEVGLLEE
KALETKAEAQ AVENTITALE QSIARYKTEY AALISETQAI KSEMSRVQFK VDRSVRLLDS
LSSERTRWED ASKSFETQIS TLVGDVLVAA AFLAYSGLYD QQFRKNMMDD WLSQLQMSGI
DFKQHNPITE YLSSADERLS WQENSLPVDD LCTENAIILK RFNRYPLIID PSGRVTEFLQ
KECKDRRLTV TSFLDDSFTK QLESSLRFGN PILIQDAEHL DPILNHVLNK EYQKTGGRVL
IQLGKQEIDF SPAFKIYLST RDPSATFAPD ICSRTTFVNF TVTQSSLQTQ SLNEVLKSER
PDVDERRSNL IKLQGEFKVH LRQLEKRLLQ ALNESRGNIL DDDNVIETLE TLKKEAAEIS
KKMSNTEGVM AEVDAITLQY NIIARSCSAV FAVLEQLHYL NHFYQFSLQY FLDIFNSVLH
DNPRLATETD HNVRRDIIIE DLFVKTYQRT SLGLLQKDRI TFAMLLAQVS PFKMEKSLID
LILDDGIDGT DLSTETDRKE EMFARAARVS ALKGKLDNIP PVDLDRFLCE EMGENFIPKI
WDDNTSEIDK ELLSLLVVKI FRLDRFVPSA ERFVTAVFGS RIFDMTEDLS QTVEQVSASR
PIALCSSPGF DASYKVDSLV ERVQASCTNI AMGSNEGLST ADKAISNAAA TGNWVLIKNV
HLAPTWLQSL EKRMDSLKPH PDFRLFLSME SSPKIPVNLL RASRVLMYEQ PAGVRANMKD
SLSSVSTRAI KTPVERTRLY LLLSFLHAVV QERLRYAPNL GWKGFWEFND SDYECSAYVI
DTWVESVSAG RSNVAPQNLP WDMLRTLITE TYGGKIDDEG DFARLTELVE SIMTPAAYEI
GHKLVESTPG LTVVTDGSDG SLVVPSGTGL KEYMEWVNKL PEREPPTYLG LPANAEKLLL
VGLGRSMIGN LGKITEILDE GEQLMAEAAV AA
//
