ID L8HQB0_9CETA Unreviewed; 489 AA.
AC L8HQB0;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=CASP8 and FADD-like apoptosis regulator {ECO:0000313|EMBL:ELR46048.1};
GN ORFNames=M91_02942 {ECO:0000313|EMBL:ELR46048.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR46048.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR46048.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
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DR EMBL; JH883687; ELR46048.1; -; Genomic_DNA.
DR AlphaFoldDB; L8HQB0; -.
DR STRING; 72004.ENSBMUP00000035796; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..78
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 97..175
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 270..366
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT COILED 166..193
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 489 AA; 56247 MW; AFE88B8F8C9A3439 CRC64;
MTLYRMSAEV IHQVEEALDE EEKDTLLFLC RDVAADVVPL NVRDLLDILR ERGKLSSVSL
AELLYRVRRF DLLKRVLNMD TPTVEALLRR HPHLISDYRV LMMEIGEDLD KSDVSSLMFL
MRDYTGRSKI AKDKSFLDLV VELEKLNLVA PDQLNLLEES LRNINRIDLK TKIQKYKQSA
QGAETNYVNA RQASLPNLSV KDPSYNLRLQ NGRSKEQRLM MGPPDIQREP VKRPIQESGA
FLPQHIVEER YKMQSKPLGI CLIIDCIGND TDILRDTFTS LGYEVKHFLY LTVKDITNIL
RQVAQMPQHQ DSDSFACILV SRGGSQSVFG VDQTHSGVPL DHIRRMFMAD TCPSLSGKPK
LFFIQSYVKS EGQLEDSSFL EVDGPSVKSA DSKARQPGPY QDLIHREADF FWSLCKADVS
LLEGPSSSPS LYLKCLSQKL WKERKHSLLE LHTELNRLVY DWNSKVSAKE RYYVWLQHTL
RKNLFLSHK
//
