ID L8HYM3_9CETA Unreviewed; 617 AA.
AC L8HYM3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Ectoderm-neural cortex protein 2 {ECO:0000313|EMBL:ELR48966.1};
DE Flags: Fragment;
GN ORFNames=M91_08024 {ECO:0000313|EMBL:ELR48966.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR48966.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR48966.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
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DR EMBL; JH882556; ELR48966.1; -; Genomic_DNA.
DR AlphaFoldDB; L8HYM3; -.
DR STRING; 72004.ENSBMUP00000025391; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd18514; BACK_KLHL25_ENC2; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF488; KELCH-LIKE PROTEIN 20; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 5.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 98..166
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELR48966.1"
FT NON_TER 617
FT /evidence="ECO:0000313|EMBL:ELR48966.1"
SQ SEQUENCE 617 AA; 67979 MW; DB37CA7865BF58E1 CRC64;
VSPRGESRAV HSLAGPGAGP CAQQPPSPPP PLPAGAGTGD ILVTRLAFHP GAVCKGREPT
CCLLNRAGDT VACSCNHASH PDCVLAHLNT LRKHRMFTDV TLWAGDRAFP CHRAVLAASS
RYFEAMFSHG LRESHDDTVN FQDNLHPEVL ELLLDFAYSS RIVINEENAE SLLEAGDMLQ
FHDVRDAAAE FLEKNLFPSN CLGMMLLSDA HQCRRLYEFS WRMCLVHFEA VRQSDDFNSL
SKDTLLDLVS SDELEAEDER VVFEAVLQWV RHDLEQRKAH LPELLRGVRL ALLPSDCLKE
AASGDALLMA DERTRLLVDE ALRCKTRILQ NDGVVTSPCA RPRRAGHTLL ILGGQTFMCD
KIYQVDHKAK EIIPKADLPS PRKEFSASAI GCKVYVTGGR GSENGVSKDV WVYNTVHEEW
SKAAPMLIAR FGHGSAELEN CLYVVGGHTS LAGVFPASPS VSLKQVEKYD PGANKWTMVA
PLRDGVSNAA VVSAKLKLFV FGGTSIHRDM VSKVQCYDPS ENRWSIKAEC PQPWRYTAAA
VLGSQIFIMG GDTEFTAASA YRFDCESNQW TRIGDMTAKR MSCHALASGN KLYVVGGYFG
TQRCKTLDCY DPTSDTW
//
