ID L8ICL6_9CETA Unreviewed; 748 AA.
AC L8ICL6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Junction plakoglobin {ECO:0000256|ARBA:ARBA00013753};
DE Flags: Fragment;
GN ORFNames=M91_17162 {ECO:0000313|EMBL:ELR53943.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR53943.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR53943.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- FUNCTION: Common junctional plaque protein. The membrane-associated
CC plaques are architectural elements in an important strategic position
CC to influence the arrangement and function of both the cytoskeleton and
CC the cells within the tissue. The presence of plakoglobin in both the
CC desmosomes and in the intermediate junctions suggests that it plays a
CC central role in the structure and function of submembranous plaques.
CC Acts as a substrate for VE-PTP and is required by it to stimulate VE-
CC cadherin function in endothelial cells. Can replace beta-catenin in E-
CC cadherin/catenin adhesion complexes which are proposed to couple
CC cadherins to the actin cytoskeleton. {ECO:0000256|ARBA:ARBA00024692}.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; JH881506; ELR53943.1; -; Genomic_DNA.
DR AlphaFoldDB; L8ICL6; -.
DR STRING; 72004.ENSBMUP00000023495; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013284; Beta-catenin.
DR PANTHER; PTHR45976; ARMADILLO SEGMENT POLARITY PROTEIN; 1.
DR PANTHER; PTHR45976:SF3; JUNCTION PLAKOGLOBIN; 1.
DR Pfam; PF00514; Arm; 3.
DR PRINTS; PR01869; BCATNINFAMLY.
DR SMART; SM00185; ARM; 12.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 9.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT REPEAT 145..183
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 187..230
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 229..271
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 271..313
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 313..356
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 394..436
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 436..478
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 483..526
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 587..629
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELR53943.1"
SQ SEQUENCE 748 AA; 82050 MW; C7F3ABF23C51309B CRC64;
AATMEVMNLI EQPIKVTEWQ QTYTYDSGIH SGANTCVPSV SSKGLIEEDE ACGRQYTLKK
TTTYTQSVPP GQGDLEYQMS TTARAKRVRE AMCPGVTGED SSLLLTTQVE GQTTNLQRLA
EPSQLLKSAI VHLINYQDDA ELATRALPEL TKLLNDEDPV VVTKAAMIVN QLSKKEASRR
ALMGSPQLVA AVVRTMQNTS DLDTARCTTS ILHNLSHHRE GLLAIFKSGG IPALVRMLSS
PVESVLFYAI TTLHNLLLYQ EGAKMAVRLA DGLQKMVPLL NKNNPKFLAI TTDCLQLLAY
GNQESKLIIL ANGGPQALVQ IMRNYSYEKL LWTTSRVLKV LSVCPSNKPA IVEAGGMQAL
GKHLTSNSPR LVQNCLWTLR NLSDVATKQE GLESVLKILV NQLSVDDVNV LTCATGTLSN
LTCNNSKNKT LVTQNSGVEA LIHAILRAGD KDDITEPAVC ALRHLTSRHP EAEMAQNSVR
LNYGIPAIVK LLNQPNQWPL VKATIGLIRN LALCPANHAP LQEAAVIPRL VQLLVKAHQD
AQRHVAAGTQ QPYTDGVRME EIVEGCTGAL HILARDPMNR MEIFRLNTIP LFVQLLYSSV
ENIQRVAAGV LCELAQDKEA ADAIDAEGAS APLMELLHSR NEGTATYAAA VLFRISEDKN
PDYRKRVSVE LTNSLFKHDP AAWEAAQSMI PMNEPYADDM DATYRPMYSS DVPMDPLEMH
MDMDGDYPID TYSDGLRPPY ATADHMLA
//
