ID L8IFR6_9CETA Unreviewed; 245 AA.
AC L8IFR6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=WAP four-disulfide core domain protein 8 {ECO:0000313|EMBL:ELR55081.1};
DE Flags: Fragment;
GN ORFNames=M91_17894 {ECO:0000313|EMBL:ELR55081.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR55081.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR55081.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
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DR EMBL; JH881305; ELR55081.1; -; Genomic_DNA.
DR AlphaFoldDB; L8IFR6; -.
DR STRING; 72004.ENSBMUP00000005748; -.
DR MEROPS; I02.978; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00109; Kunitz-type; 1.
DR Gene3D; 4.10.75.10; Elafin-like; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008197; WAP_dom.
DR InterPro; IPR042931; WFDC8/12/15B-like.
DR PANTHER; PTHR47769; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8; 1.
DR PANTHER; PTHR47769:SF1; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00095; WAP; 3.
DR PRINTS; PR00003; 4DISULPHCORE.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SMART; SM00217; WAP; 3.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF57256; Elafin-like; 3.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51390; WAP; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 43..245
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003991835"
FT DOMAIN 48..95
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 99..149
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 151..198
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 199..244
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT NON_TER 245
FT /evidence="ECO:0000313|EMBL:ELR55081.1"
SQ SEQUENCE 245 AA; 27435 MW; 5D531795739A92B6 CRC64;
VPNPCPLLFP FHRHLPLHSS TFSWRNVALL LLLSLSLEQT SASPSYRVKM KPGKCPQERI
TCSSKAPDLC KTDFNCGEYL KCCPFACGKK CMDPYEEPCL LPLDQGHCKN TVQQWYFNTK
ERVCKPFLYG GCLGNANNFS KKEDCMQACL SAVKDGQCPL FPFKNRMECS ASCKSDYDCP
LNEKCCESMC GFDCAMAWTV KAGFCPNKPP ICSTIDRPKC LQDNDCPLTT KCCSRCGLKC
LESLK
//
