ID L8IG27_9CETA Unreviewed; 2633 AA.
AC L8IG27;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Filamin-B {ECO:0000313|EMBL:ELR54082.1};
GN ORFNames=M91_00830 {ECO:0000313|EMBL:ELR54082.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR54082.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR54082.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; JH881482; ELR54082.1; -; Genomic_DNA.
DR RefSeq; XP_005899056.1; XM_005898994.2.
DR STRING; 72004.ENSBMUP00000005779; -.
DR Ensembl; ENSBMUT00000006705; ENSBMUP00000005779; ENSBMUG00000004321.
DR GeneID; 102265714; -.
DR KEGG; bom:102265714; -.
DR CTD; 2317; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21309; CH_FLNB_rpt1; 1.
DR CDD; cd21313; CH_FLNB_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 139..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 249..347
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 349..446
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 447..543
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 544..636
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 640..736
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 737..839
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 840..938
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 939..1034
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1035..1127
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1128..1222
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1223..1322
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1323..1415
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1416..1542
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1543..1639
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1640..1735
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1740..1847
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1847..1939
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1950..2025
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2028..2120
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2118..2216
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2219..2311
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2313..2406
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2410..2502
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2538..2632
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 244..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2633 AA; 281618 MW; 0160116F6A55641C CRC64;
MPVTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVNKRIGNL QTDLSDGLRL IALLEVLSQK
HMYRKYHQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK AIVDGNLKLI LGLVWTLILH
YSISMPVWED EGDDDAKKQT PKQRLLGWIQ NKIPYLPITN FNQNWQDGKA LGALVDSCAP
GLCPDWESWD PRKPVDNARE AMQQADDWLG VPQVITPEEI IHPDVDEHSV MTYLSQFPKA
KLKPGAPLKP KLNPKKARAY GRGIEPTGNM VKQPAKFTVD TISAGQGDVM VFVEDPEGNK
EEALVTPDSD KNKTYSVEYL PKVTGLHKVT VLFAGQHISK SPFEVNVDKA QGDASKVTAK
GPGLEVASNI ANKPTYFDIY TAGAGVGDIG VEVEDPQGKN TVELLVEDRG NQVYRCVYKP
MQPGPHVVKV SFAGDTIPKS PFVVQVGEAC NPNACRASGR GLQPKGIRIR ETADFKVDTK
AAGSGELGVT IKGPKGLEEL VKQKGFQDGV YAFEYYPSTQ GKYSVSITWG GHHIQKSPFE
VQVGPEAGMQ KVRAWGPGLH GGIVGRSADF VVESIGSEVG SLGFAIEGPS QAKIEYDDQN
DGSCDVKYWP KEPGEYAVHI MCDDEDIKDS PFMAYIHPAS GDYNPDLVQA YGPGLEKSGC
IVNNLAEFTV DPKDAGKAPL KIFAQDGDGQ PIDIQMKSRM DGTYACSYTP VKAIKHTIAV
VWGGVNIPHS PYRVSIGQGS HPQKVKVFGP GVERSGLKAH EPTHFTVDCT EAGEGDVSVG
IKCDARVLSD EEEDVDFDII HNANDTFTVK YVPPAAGRYT IKVLFASQEI PTSPFRVKVD
PSHDASKVKA EGPGLSKAGV ENGKPTHFTV YTKGAGKAPL NVQFSSPGPG DAVKDLDIID
NYDYSHTVKY TPTQQGNMQV LVTYGGDPIP KSPFTVGVAA PLDLSRIKIN GLENRVEVGK
DQEFAVDTRG AGGQGKLDVT ILSPSRKVVP CLVAPVAGRE SSTAKFIPRE EGLYAIDLTY
DGHPVPGSPY MVEASLPPDP TKVKAHGPGL RGGLVGKPAE FTIDTKGAGT GGLGLTVEGP
CEAKIECSDN GDGTCSVSYL PTKPGEYFVN ILFEEVHIPG SPFKADIEMP FDPSKVVASG
PGLEHGKVGE PGLLSVDCSE AGPGTLGLEA VSDSGAKAEV CIENNKDGTY AVTYVPLTAG
MYTLTMKYGG ELVPHFPTRV KVEPAVDTSR VKVFGPGIEG KDVFREATTD FTVDSRPLTQ
VGGDHIKAHI ANPSGASTEC FVTDNADGTY QVEYTPFEKG LHVVEVTYDD VPVPNSPFKV
AVTEGCQPSR VQAQGPGLKE AFTNKPNVFT VVTRGAGIGG LGITVEGPSE SKINCRDNKD
GSCSAEYVPF APGDYDVNIT YGGAHIPGSP FRVPVKDVVD PSKVKIVGPG LGSGVRARVL
QSFTVDSSKA GLAPLEVRVM GPRADQTISW SRRSPLKAIS GFFKRDRKGD FMETGLVEPV
NVVDNGDGTH TVTYTPSQEG PYMVSVKYAD EEIPRSPFKV KVLPTYDASK VTASGPGLST
YGVPASLPVE FAIDARDAGE GLLAVQITDQ EGKPKRAIVH DNKDGTYAVT YIPDKTGRYM
IGVTYGGDDI PLSPYRIRAT QTGDASKCLA TGPGIASTVK TGEEVGFVVD AKTAGKGKVT
CTVLTPDGTE AEADVIENED GTYDIFYTAA KPGTYVIYVR FGGVDIPNSP FTVMATDGEV
AAVKEVPVNA CPPGFRPWVT EEAYVPVSNM NGLGFKPFDL VIPFAVRKGE ITGEVHMPSG
KTATPEIVDN KDGTVTVRYA PTEVGLHEMH IKYMGSHIPE SPLQFYVNYP NSGSVSAYGP
GLVYGVANKT ATFTIVTEDA GEGGLDLAIE GPSKAEISCI DNKDGTCTVT YLPTLPGDYS
ILVKYNDKHI PGSPFTAKIT DDSRRCSQVK LGSAADFLLD ISETDLSTLT ASIKAPSGRD
EPCLLKRLPN NHIGISFIPR EVGEHLVSIK KNGNHVANSP VSIMVVQSEI GDARRAKVYG
RGLSEGRTFE MSDFIVDTRD AGYGGISLAV EGPSKVDIQT EDLEDGTCKV SYFPTVPGVY
IVSTKFADEH VPGSPFTVKI SGEGRVKESI TRTSRAPSVA TVGSICDLNL KIPEIDSSDM
SAHVTSPSGR VTEAEIVPVG KNSHCVRFVP QEMGVHTVSV KYRGQHVTGS PFQFTVGPLG
EGGAHKVRAG GPGLERGEAG VPAEFSIWTR EAGAGGLSIA VEGPSKAEIT FDDHKNGSCG
VSYIAQEPGN YEVSIKFNDE HIPESPYVVP VIAPSDDARR LTVLSLQESG LKVNQPASFA
IRLNGAKGKI DAKVHSPSGA VEECHVSELE PDKYAVRFIP HENGIHTIDV KFNGSHVVGS
PFKVRVGEPG QAGNPALVSA YGAGLEGGST GIQSEFFINT TRAGPGTLSV TIEGPSKVKM
DCQETPEGYK VMYTPMAPGN YLIGVKYGGP NHIVGSPFKA KVTGQRLVSP GSANETSSIL
VESVTRSSTE TCYSAIPKAS SDASKVTSKG AGLSKAFLGQ KSSFLVDCSK AGSNMLLIGV
HGPTTPCEEV SMKHVGNQQY NVTYVVKERG DYVLAVKWGE EHIPGSPFHV TVP
//
