ID L8IG82_9CETA Unreviewed; 3301 AA.
AC L8IG82;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Laminin subunit alpha-3 {ECO:0000313|EMBL:ELR54132.1};
DE Flags: Fragment;
GN ORFNames=M91_00534 {ECO:0000313|EMBL:ELR54132.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR54132.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR54132.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; JH881470; ELR54132.1; -; Genomic_DNA.
DR STRING; 72004.ENSBMUP00000028709; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 12.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 12.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF444; -; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 14.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 9.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..254
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 382..425
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 454..498
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 499..544
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 594..646
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1232..1277
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1322..1370
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1371..1421
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1442..1619
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1653..1699
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1700..1752
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2356..2557
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2564..2726
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2733..2893
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2954..3118
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3125..3298
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1847..1909
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1958..2165
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2305..2349
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 401..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 454..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 474..483
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 499..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 501..518
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 520..529
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 617..626
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1232..1244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1234..1251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1253..1262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1346..1355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1371..1383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1373..1390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1392..1401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1672..1681
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1700..1712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1723..1732
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT NON_TER 3301
FT /evidence="ECO:0000313|EMBL:ELR54132.1"
SQ SEQUENCE 3301 AA; 364036 MW; ECEFBBC02F0DF115 CRC64;
LSLHPPYFNL AEAARIWATA TCGEREPGGT RPRPELYCKL VGGPTAPGSG HTIQGQFCDY
CNSEDPRKAH PVTNAIDGSE RWWQSPPLSS GMQYNKVNVT LDLGQLFQVA YVLIKFANSP
RPDLWVLERS VDFGSTYSPW QYFAHSKVDC LEQFGQEANR AITRDDDVLC TTEYSRIVPL
ENGEVVVSLI NGRPGAKNFT FSHALREFTK ATNIRLRFLR TNTLLGHLIS KAQRDPTVTR
RYYYSIKDIS IGGRCVCNGH AEVCNANNPE KLFRCECQHN TCGDTCDRCC MGYNQRRWRP
AMGKQSNECE ACNCHGHSTD CYYDPDVERQ QASLNIQGLY AGGGVCINCQ HNTAGVNCEK
CAKGYYRPYG IPVHAHDGCI PCSCHPEHAE DCEQGSGRCT CRPNFRGDHC EECAAGYYHF
PVCSRIPILP ISTPSPEDPV AGDIIKGKQE HWSCDCNLEG VLPEICDAQG RCLCRPGVGG
ARCDACLPGF YSFPICQACQ CSALGSYQTP CSPVTGQCEC RPGITGQRCD RCLSGASDFP
HCQGSSNICD PAGTVDSSLG HCQCKLHVES PSCSICKPLY WNLAKENPDG CSECRCHVAG
TMSGIGECGQ LDGDCHCKSH VGGDSCDTCE DGYFALEKSN YFGCQGCQCD IGGAVTPVCS
GRSGVCQCRE HVVGKACQRP ENNYYFPDLH HMRYEIEDGT TPGGRALRFG FDPLEFPEFS
WRGYAQMTPV QNEVRIMLNV GKSSLSLFHV VLRYMNPETE AVSGRITIYP SWAKAGAAQT
KEIIFQPSKE PAFVTVPGNG FADPFSIVPG TWIACIKVEG VLLDYLVLLP RDYYEAPSLQ
LPVTEPCAHV GHPQENCLLY QHLPVTRFPC ALACEARHFL LDGEPRPLAV RQPTPAHPVM
ADLSGREVEL HLRLRVPRVG HYVIMVEYAT EADQLSEVAV HIQSPGADLA GRVDIYSCKY
CVLCRSTVTD GRGRLAVYEL LADADVQLRA RMAQFLLHQI CIIPIEEFST EYLRPHVKCI
ASYGRFVNQS ASCVSLIPET PPTALILDVP SGGSSPLLPE DPSPPADAVL GVTLKAPQNQ
VTLRGLVPRP GRYVIVVHFY QPAHPTFPAQ VSVDGGRLQA GVFRASFCPH VLGCRDQVIT
GDQVEFDISE PEVALTVTVP EGKSLVLVRI LVVPAENYDY QILHRKSLDK SLEFATNCGG
DSFYIDPQRA SEFCKNSARS LVALYHEGAL PCECHPAGAT GHPCSPEGGQ CPCRPHVIGR
QCTRCQTGFY GFPHCKPCSC GRRLCEETTG RCLCPPLTVR PQCDVCEVHS FSFHPLAGCE
GCNCSRTGTD GTATPECDRD HGQCRCRPRI TGRQCDRCAP GFYRFPECLP CHCNRDGTEP
GVCDPGTGAC LCKENVQGTE CNMCREGSFY LDPANPKGCT SCFCFGASHH CHSTHKRRAK
LVDMMGWRLQ TADGVDIPVS FNPGSSSVVA DLQELPATVH SASWVAPPSY LGDKVSSYGG
YLTYQIKSFG LPADMVPLEK KPDVQLIGQH MSIIYHEPNH PRPDRLHHGR VQMVEGNFRH
ASSQAPVSRE ELMTVLSRLQ GVHLRGLYFT ETQRLTLSGV GLEEASETGS GRRAQSVEMC
ACPPDYTGDS CQGCSPGYYR ENKGLYTGWC VPCNCNGHSN RCQDGSGICI NCQHNTAGEH
CERCKEGYYW NTIHGSCRVC PCPHSDSFAT GCVVTGENVK CSCKPGYTGT RCERCAPGYF
GNPQKFGGSC QPCNCNSNGQ LGSCDPLNGD CINQEPKDSG PGEECDDCDS CVMTLLNDLA
TMDDELRLVK SQLQGLSVSA GTLEQIRRLE TQTKDLRNQL LSYRPTISNH KSKMDGLEKE
LSNLNREFET LQEKVQINSR KAQTLYNNID RTTQSAKELD SKIKNVIRNV HILVKQISGT
EGDGNRLPSG DFSRELAEAG RMMRELRTRN FGKHLRDAEA ERREAQQVLN RIRSWLENHQ
MENNGLAKNI RDALNDYEAK LSGFRAALQE ASTQAKQATG LNRENERALE SIKRQVKEMN
SLQSDFTKRL ATADSSLMQT NIVLQLMKKS HEEYEKLAVT LNEARHELSD KVRELSRSAS
RASLVEEAER HSQSLQELAK QLEEIKRNAS GDELVRCAVD AATAYENILN AIKAAEDAAD
KATTASEAAL QTVIKEDLPR KAKTLSSNSD KLLNEAKITQ QKLQQEISPA LNNLQQTLKT
MTVQKGLIDT NLTSIRGDLR GIQRDDIDGI ISSAKSLVRN ANDITNEVLD GLNPIQTDVE
RIKDTYGSTQ SEDFNKALSD ADNSVKKLTN KLPDLLSKIE SINQQLLPLG NISDNVDRIR
ELIQQARDAA NKVAVPMRFN GRSGVEVRLP NDLEDLKGYT SLSLFLQRPE ATETGGTENM
FVMYLGNKDA SRDYIGMAVV DGQLTCVYNL GEDEAELQVD QTLTESKTQE AVMDRVKFQR
IYQFARLNYT LKATSSKPET HQFHDMDSGN SNTLLNLDPE NAVFYVGGYP TDFRPPSRLK
FPPYKGCIEL DDLNENVLSL YNFKKTFNLN TTEVEPCRRR KEESDKNYFE GTGYARVPTQ
PNAPFPTFGQ TIQTTVDRGL LFFAENQDHF ISLNVEDGRL MVRYKLNSEP PKEKGIRDII
NDGKDHLVQI KIGKVQQRMW INVDIQSVKI EDDIFDFSTY YLGGIPISIR ERFNISTPAF
RGCMKNLKKT TGVVRLNDTV GVTKKCSEDW KLVRSASFSR GGQLSFTNLD FPSSSHFQAS
FGFQTFQPSG ILLSHQMGAS SLQVTLEDGH IELSTRDSSS PIFTSPQTYM DGLLHYVSVI
SDNSGLWLLI DDQPLKNNQR LRGLSGFPQS LRLGGSHFEG CISNVFIQRS SESPEVLDLA
SKSSKRDVSL GFCSLNEPPF LMLLKGSTRF YKAKTFSIHQ PLQDAPAISP RSSKAWREAQ
SCPPLPGVQT SHRALRFGDS PTSHLLFMLP QELLKSRSQF AVDVLTTASR GLVFYTGTRS
SFMALYLSKG RLVFALGAEG KKLKLKSKEK CNDGKWHTVT FGQDGGKGRL VVDGLRTREG
HLPGNSTISL RAPVYLGSAP SGKPKSLPQN SFVGCLRNFQ LDLKPLETPS ASFGVSPCLG
SSLEKGIYFS QEGGHIILAN SVSLGPEFKL VFSIRPRSLT GILIHIGSQP GQHLCVYMEG
GKVTASVGSE AGEVLTSVTP KQALCDGQWH SVAVTIKQHI LHLKLDAEDS YTAGRHPFPP
ARPLERLYIG GVPGNLKTPK LPVWTSFFGC LRNIQVNHIP VPVTGAAEVQ GTVSLNGCPD
H
//
