ID L8IPU6_9CETA Unreviewed; 530 AA.
AC L8IPU6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Interferon alpha/beta receptor 2 {ECO:0000313|EMBL:ELR58078.1};
GN ORFNames=M91_17693 {ECO:0000313|EMBL:ELR58078.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR58078.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR58078.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; JH880890; ELR58078.1; -; Genomic_DNA.
DR RefSeq; XP_005893407.1; XM_005893345.2.
DR AlphaFoldDB; L8IPU6; -.
DR STRING; 72004.ENSBMUP00000010915; -.
DR GeneID; 102275218; -.
DR KEGG; bom:102275218; -.
DR CTD; 3455; -.
DR OrthoDB; 4258084at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR20859:SF84; INTERFERON ALPHA_BETA RECEPTOR 2; 1.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:ELR58078.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..118
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 133..232
FT /note="Interferon/interleukin receptor"
FT /evidence="ECO:0000259|Pfam:PF09294"
FT REGION 366..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 59544 MW; 7445D69A640C86CD CRC64;
MLLSQNVSAI GPLNLYPMVH ISLVFGISYV APVLSDEHCT LKMRFRNFQS VLSWELKNHS
IVPTHYTLWY TIMSKREDMK VVKDCINVTR SFCDLTDVWV NTTDMYIPQV VGFRENAKLV
ICMGSFFLAP DKPLDPPEFE IVGFTNHISV NVKFQFDSPG ILSEELQFYL AFIEEHAGNS
VKRHQPQITG NITKNFNYVI DKLIPNTNYC ISVYFEPKDP RKINRSPLKC TLFRPRRESE
SSESATIGGI ITLFLITAVF ISTVMILKRI GYICLRNDFP KVLNFYKLSV WVFPELPPLE
KVATVEVIHV NRKKKVWNYN YDDENDIENE AAPHLNSGGY TKHGLTGKLC PTSTTSASLE
DCSLEDCSEP SAKEPYLPEP KGDAETPMAP GPGPWQSEGT SGGYQTRGTL WQDPTSEEDS
DSTEGSEGRI VFNVNLNSVC VRALEDDKDS EVTLMSPSCP EETVELEDLN ETESSVLVAS
EEGTQLPFTN PSTECPRPQD APSDKSDTSE SDVDMGDGYI VRQVNLKKFN
//
