ID L8ISI8_9CETA Unreviewed; 1171 AA.
AC L8ISI8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Integrin alpha-11 {ECO:0000313|EMBL:ELR58132.1};
DE Flags: Fragment;
GN ORFNames=M91_20551 {ECO:0000313|EMBL:ELR58132.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR58132.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR58132.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; JH880886; ELR58132.1; -; Genomic_DNA.
DR AlphaFoldDB; L8ISI8; -.
DR STRING; 72004.ENSBMUP00000008466; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1125..1149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 7..68
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 74..134
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 147..328
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 338..389
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 445..510
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 511..569
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 573..633
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT NON_TER 1171
FT /evidence="ECO:0000313|EMBL:ELR58132.1"
SQ SEQUENCE 1171 AA; 131215 MW; 64BA550E60BB4DF2 CRC64;
GFTATFNMDT KKPRVIPGSR AAFFGYTVQQ HDISGRKWLV VGAPLETNGH QKTGDVYKCP
VTQGNCTKLN LGRVTLSNVS ERKDNMRLGL SLATNPKDNS FLACSPLWSH ECGSSYYTTG
MCSRVNSNFR FSKTVAPALQ RCQTYMDIVI VLDGSNSIYP WVEVQHFLIN ILKKFYIGPG
QIQVGVVQYG EDVVHEFHLN DYRSVKDVVE AASHIEQRGG TETRTAFGIE FARSEAFQKG
GRKGAKKVMI VITDGESHDS PDLEKVIQQS ERDNVTRYAV AVLGYYNRRG INPEAFLNEI
KYIASDPDDK HFFNVTDEAA LKDIVDALGD RIFSLEGTNK NETSFGLEMS QTGFSSHVVE
DGILLGAVGA YDWNGAVLKE TSSGKVIPLR ESYLKEFPEE LKNHGAYLGY TVTSVVSSRQ
GRVYVAGAPR FNHTGKVILF TMHSNRSLTI HQALRGEQIG SYYGSEITSV DVDEDGVTDV
LLVGAPMYFS EGGERGRVYV YNLRQDRFVY NGTLKDSHGY QNARFGSSIA SVRDLNQDSY
NDVVVGAPLE DNHGGVLYIY HGFQGSILKT PKQRIPASEL APGLQYFGCS IHGQLDLDED
GLVDLAVGAL GNAVILWSRP VVQINASLHF EPSKINIFHR DCKRSGRDAT CLAAFLCFTP
VFLAPHYQTA IVGIRYNATM DERRYTPRAH LDEGGDRYTN RAALLSSGQE HCERISFHVL
DTADYVKPVT FSIEYSLEDP DYGPMLDDGW PTTLRVSVPF WNGCNEDEHC VPDLLLDARS
DLPTAMEYCQ RVLRKPVQDC SAYTLSFDAA VFVIESMRRR VAVEALLENK GENAYSTVLN
ISQSANLQFA SLIQKDDSDG SIECVNEERR LHKKVCNVSY PFFRAKAKVA FRLDFEFSKS
IFLHHLEIQL TAGSDSDEEE STKEDNTALL RFHLKYEADV LFTRSSSLSH YEVKSNSSLE
RYHGIGPPFH CIFKIQNLGL FPIHGVTMKI TIPIATRGGN RLLLLRDFLT DQVNTSCNIW
GNSTEYRRAP TEEDLSRTPQ LNHSNSDVVS INCNVRLAPN QEINFHLLGN LWLRSLKALK
YKLMRITVHA ALQRQFHSPF IFREEDPSRQ ITFEISKQED SQVPIWIIVG STLGGLLLLA
LLVLALWKLG FFKSAKRRRE PGLDPTPKVL E
//
