ID L8ITX6_9CETA Unreviewed; 553 AA.
AC L8ITX6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Kelch-like protein 31 {ECO:0000313|EMBL:ELR59483.1};
GN ORFNames=M91_02548 {ECO:0000313|EMBL:ELR59483.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR59483.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR59483.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
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DR EMBL; JH880708; ELR59483.1; -; Genomic_DNA.
DR RefSeq; XP_005891472.1; XM_005891410.2.
DR AlphaFoldDB; L8ITX6; -.
DR STRING; 72004.ENSBMUP00000006748; -.
DR GeneID; 102268231; -.
DR KEGG; bom:102268231; -.
DR CTD; 401265; -.
DR OrthoDB; 5472491at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:InterPro.
DR CDD; cd18470; BACK_KLHL31_KBTBD1; 1.
DR CDD; cd18260; BTB_POZ_KLHL31_KBTBD1; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR030604; BTB_POZ_KLHL31.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF17; KELCH-LIKE PROTEIN 31; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 4.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..137
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 553 AA; 61389 MW; 264D0AB4FA470C5A CRC64;
MAPKKKTVRK NKADVNEMTI IVEDSPLNKL NALNGLLEGG NGLSCISSEL TDASYGPNLL
EGLSKMRQEG FLCDLVISTK TKSFDVHKSV MASCSEYFYN ILKKDPSTQR VDLNDIAPLG
LATVIAYAYT GKLTLSLYTI GSIISAAVYL QIHTLVKMCS DFLIQEMSVE NCMYIANIAE
TYSLRNAKAA AQKFIRDNFL EFAETDHFMK LTFEQINELL IDDDLQLPSE IVAFQIAMKW
LEFDQKRVKY AADLLSNIRF GTISAQDLVN YVQSVPRMMQ DADCHKLLVD AMNYHLLPYH
QNTLQSRRTR IRGGCRVLVT VGGRPGLTEK SLSRDVLYRD PEIGWSKLTE MPAKSFNQCV
AVMDGFLYVA GGEDQNDARN QAKHAVSNFC RYDPRFNTWI HLANMTQRRT HFSLSVFNGL
LYAVGGRNAE GSLASLECYV PSANHGERVD VLTVESFCPA SGQWSYAAPL PVGVSTAGGA
ALHGRAYLLG GWNEGERKYK KCIQCFNPEL NEWTEDDELP EATVGVSCCA LAMPNPVTRE
SRASSVSSVP VSI
//
