ID L8J1P2_9CETA Unreviewed; 4318 AA.
AC L8J1P2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN ORFNames=M91_06498 {ECO:0000313|EMBL:ELR62148.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR62148.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR62148.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; JH880376; ELR62148.1; -; Genomic_DNA.
DR STRING; 72004.ENSBMUP00000016369; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT DOMAIN 1684..1830
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1971..2127
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2283..2431
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1929..1972
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2940..2977
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3110..3200
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4318 AA; 493936 MW; F8A2935BAA341CDE CRC64;
MAGVPGDVRK LFIFATTRNY FGLVSESWDH ALLGNGPEIN NFLDDGNQML LRVQRSDSGI
AFSNVIDFAD TKDKVLVFFK LRPEVITDQN LHNNILVSSM LESPINSLYQ AVRQVFAPML
LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLSKLK FKEDDTRGIL TPSDEFQFWI
EQAHRGSKQI TKERASYFKE LFETIAREFY NLDGLSLLEV VDLVETTRDV VDDVWRQTEH
DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KENLKAGISV CEQWVTACSH
LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAVRTI HEKLLYFSPA SDEKIICLAR
VFEPFSGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA
FLKYKELVKR PTISKELMLE RETLLARLMD SVKDFRLDFE NRCRGIPGDA SGPLAGKNLS
EVVNNIVWVR QLELKVDDTI KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR
DIQSGLSDSK SGLCIEANSR IMELDPNDGS LKVHYSDRLV VLLREVRQLS ALGFVIPAKI
QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK
SHITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD
GLQELRTGLA SVEAQGFQAS DMHAWKQHWN HQVYKALEHQ YQMGLEALNE NLPEINIDLI
YKQGRLQFKP PFEEIRAKYY REMKRFISIP NQFKGVGEAG DESIFSIMID RNASGFLTIF
SKAEDLFRRL SAVLHQHKEW IVIGQVDMEA LVEKHLSTVH DWEKNFKALK IKGKEVERLP
SAVKVDCLNI NCNPVKTVID DFIQKLFDML VLSLKKSIQA HLHEIDTFVT EAMEVLTIMP
QSVEEIGNAN LQYSKLQERK PEILPLFQEA EDKNRLLRTV AGGGLETISN LKAKWDKFEL
MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LEKFKARWDQ LKPGDDVIET GQLNTLDQSA
KSIKEKKVEF DDLEVIRKKL LDDCHHFGLE EPNFSLAYSI SKDIESCAQI WALYEEFQQG
FQEMANEDWI TFRTKTYLFE EFLMNWHDRL RKIEEHSAMT VKLQSEVDKY KIAIPVLKYV
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTV VAKASDLKDL NSRAQGEVTI
REALRELDLW GVGAVFTLVD YEDSQSRTIK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG
FEDKVSIWER KLADLDEYLQ NLNHIQRKWV YLEPIFGHGA LPKEQTRFNR VDEDFRSIML
DIKKDNRVTT LTTHAGIRNS LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI
LGQSTNPSVI QSHLKKLFAG IHSVCFDEEL KHITAMKSLE GEVVPFKNKV LLSSNVETWL
NDLALEMKQT LKELLTECVT AGRSSQGAID PSFFPSQILC LAEQIKFTED VENAIKDHSL
HQIETQLVNK LEHYTNIDTS SEDPGNTESG ILELKLKALI LDIIHNIDVV KQLNQVQIHT
TEDWAWKKQV RFYMKSDHTC YVQMVDSELQ YTYEYQGNAP KLVYTPLTDK CYLTLTQAMK
MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF
DEFNRLEESV LSAVSMQIQT IQDALKNHRT VCELLGKEVE INSNSGIFIT MNPAGKGYGG
RQKLPDNLKQ LFRPVAMSRP DNELIAEVIL YSEGFKDAKV LGRKLVAIFN LSRELLTPQQ
HYDWGLRALK TVLRGSGNLL RQLKKTSVKQ NVNESHIVVQ ALRLNTMSKF TFADCTRFDA
LIKDVFPGID FKEVEYDELS AALKQVFEEA NYEIISNQIK KALELYEQLR QRMGVVIVGP
SGAGKSTLWR MLRAALCKTG RVVKQYTMNP KAMPRHQLLG HIDMDTREWS DGVLTNSARQ
VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGQNV NFLFETHDLS
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPPTYRNN LENWIGDYFE KALQWVLKQN
DYVVETSLVG TVMNGLSHLH GCRDHDQFII NLIRGLGGNL NLKSRLEFTK EVFNWARQSP
PDPHKPLDTY YDSNRGRLAS YVLKKPENLT ADDFSSSHTL PVIQTPDMQR GLDYFRPWLS
PDTKQPFILV GPEGCGKGML LRYAFSQLRS TYIATVHCST QTTSQHLLQK LSQTCMVIST
NTGRVYRPKD CERLVLYLKD INLPRLDKWG TSTLIAFLQQ VLTYQGFYDE NLEWVGLENI
QIVASMSAGG RLGRHQLTTR FTSIVRLCAI DYPEREQLQT IYGAYLEPVL HKNLKNHSVW
GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL
DYVLEIVAYE ARRLFRDKIV GAKELHLFDS ILTSVFQGDW GSDVLDNMAD NFYVTWGAQH
TSGTRSVPGQ PLPPHGKPLG KLNSSDLKDV IKKGLIHYGR DNQNLDILLF QEVLEYMSRI
DRVLSFPGGS LLLAGRSGVG RRTITSLVSH MHGAVLFSPK ISRGYELKHF KNDLKYVLHL
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGKWMGEVP GLYTLEELEP LLLPLKDQAS
QDGFFGPVFN YFTYRVQQNL HIVLIMDSAN LNFIINCESN PALHKKCQVL WMEAWSDSSM
KKIPEMLLSE MGGDERYSDK KRKEEKKKKS VDPEFLKSFL LIHESCKAYG ATPSRYMTFL
RVYSAISSSK KEELLKRQSH LQAGVSKLNE AKALVAELNR TAGEQSVLLK TKQDEADAAL
QEITVSMQDA SEQKTELERL KHRIAEEVIK IEERKNKIDD ELKEVQPLVN EAKLAVGNIK
PESLSEIRSL RMPPDVIRDI LEGVLRLMGI FDTSWVSMKS FLAKRGVRED IATFDARNIP
KEIRESVEEL LFKNKGSFDP KNAKRASTAA APLAAWVKAN VQYSHVLERI QPLETEQAGL
ESNLQKTEDR KRKLEELLNS VGQKVSELKE RFQSRTSEAA KLEAEVSKAQ ETIKAAEVLI
NQLDREHRRW NAQVAEITEE LATLPKRAQL AAAFITYLSA APEGLRKTCL EAWTKFTGLE
KFDLRRFLCT ESEQLIWKSE GLPSDDLSIE NALVILQIIG LKSWSRVCPF LIDPSSQATE
WLKTHLKDSR LEVINQQDSN FITALELAVR FGKTLIIQEM DGVEPVLYPL LRRDLVAQGP
RYVVQIGDKI IDYNEEFRLF LSTRSPNPFI PPDAASIVTE VNFTTTRSGL RGQLLALTIQ
HEKPDLEEQK TKLLQQEEDK KIQLAKLEES LLETLATSQG NILENKDLIE SLNQTKASSA
LIQESLKESY KLQISLDQER DAYLPLAESA SKMYFIISDL SKINNMYRFS LASFLRLFQR
ALQNKQDSEN TEQRIKSLIN SLKHMVYEYI CRCLFKADQL MFALHFIRGM HPELFQENEW
DTFTGVVVGD MLRKVDSQQR IRDQLPSWID QERSWAVATL KIALPSLYQT LCFEDVALWR
TYYHNSMCEQ EFPSSLIKKV SLFQQVLVVQ TLRPDRLQSA MALFACKTLG LKELSPPPLN
LKRLYKETLE IEPILIIISP GADPSQELQE LANAERSGEC YHQIAMGQGQ ADLAVQMLKE
CARSGDWLCL KNLHLVVSWL PVLEKELNTL QPKDTFRLWL TAEVHPSFTP ILLQSSLKIT
YESPPGLKKN LMRTYESWSP EQISKKDNVH RAHALFSFAW FHAACQERRN YIPQGWTKFY
EFSLSDLRAG YNIIDRLFDG SKDVQWEFVH GLLENAIYGG RIDNYFDLRV LRSYLKQFFN
SSIIDVLSKR NKKSVFPYSI SLPKSCSILD YRAVIEKLPE DDKPSFFGLP ANIARSSQRM
ISSQVISQLK ILGRSVTAGC KFDREIWSNE LSPVLNLWKK LNQNSNLIHQ KLLPPNDRQG
SPILSFIILE QFNAIRLVQS VHQSLAALSK VIRGTTLLSS EVQKLASALL NQKCPLTWQS
KWEGPEDPLQ YLRGLVARAL AIQSWVERAE KQTLLSDTLD LSELFHPDTF LNALRQETAR
AMVCSVDSLK FVASWKGRLQ EAKLQIKISG LLLEGCSFDG NRLCENQHDS PSVSSVLPCF
MGWIPQAAYG PYSPDECISL PVYTSAERDR VVINVSIPCG GNQDQWIQCG AALFLKNQ
//
