ID L8JND1_9BACT Unreviewed; 326 AA.
AC L8JND1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Phosphohexomutase {ECO:0000256|ARBA:ARBA00029741};
DE AltName: Full=Phosphomannose isomerase {ECO:0000256|ARBA:ARBA00030762};
GN ORFNames=C900_03710 {ECO:0000313|EMBL:ELR70456.1};
OS Fulvivirga imtechensis AK7.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Fulvivirgaceae;
OC Fulvivirga.
OX NCBI_TaxID=1237149 {ECO:0000313|EMBL:ELR70456.1, ECO:0000313|Proteomes:UP000011135};
RN [1] {ECO:0000313|EMBL:ELR70456.1, ECO:0000313|Proteomes:UP000011135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK7 {ECO:0000313|EMBL:ELR70456.1,
RC ECO:0000313|Proteomes:UP000011135};
RA Nupur N., Khatri I., Kumar R., Subramanian S., Pinnaka A.;
RT "Genome assembly of Fulvivirga imtechensis AK7.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR036894-1};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR036894-1};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELR70456.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMZN01000053; ELR70456.1; -; Genomic_DNA.
DR RefSeq; WP_009581104.1; NZ_AMZN01000053.1.
DR AlphaFoldDB; L8JND1; -.
DR STRING; 1237149.C900_03710; -.
DR PATRIC; fig|1237149.3.peg.3473; -.
DR eggNOG; COG1482; Bacteria.
DR OrthoDB; 9808275at2; -.
DR Proteomes; UP000011135; Unassembled WGS sequence.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd07010; cupin_PMI_type_I_N_bac; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR InterPro; IPR014628; Man6P_isomerase_Firm_short.
DR InterPro; IPR049071; MPI_cupin_dom.
DR InterPro; IPR046457; PMI_typeI_cat.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR42742:SF3; MANNOSE-6-PHOSPHATE ISOMERASE GMUF-RELATED; 1.
DR PANTHER; PTHR42742; TRANSCRIPTIONAL REPRESSOR MPRA; 1.
DR Pfam; PF21621; MPI_cupin_dom; 1.
DR Pfam; PF20511; PMI_typeI_cat; 1.
DR PIRSF; PIRSF036894; PMI_Firm_short; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ELR70456.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR036894-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011135};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR036894-1}.
FT DOMAIN 7..116
FT /note="Phosphomannose isomerase type I catalytic"
FT /evidence="ECO:0000259|Pfam:PF20511"
FT DOMAIN 245..323
FT /note="Mannose-6-phosphate isomerase cupin"
FT /evidence="ECO:0000259|Pfam:PF21621"
FT ACT_SITE 199
FT /evidence="ECO:0000256|PIRSR:PIRSR036894-2"
FT BINDING 104
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR036894-1"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR036894-1"
FT BINDING 179
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR036894-1"
SQ SEQUENCE 326 AA; 36625 MW; FFA9DD06CA85E852 CRC64;
MNAYPLKFKA IFKDKIWGGQ KIGTILKKDY SPLPNCGETW ELSAVEGNVS IVDNGELAGE
PLDRVIAAHR NEILGSSVVK KFGDEFPLLI KFIDAKEDLS VQVHPDDELA QVRHQGKGKT
EMWYILQADA DASLIAGFNQ PMDKTSYLDH FNKGALNNVL NRVSVHAGDV FFIPAGRIHT
IGKGILLAEI QQTSDITYRI YDFDRIDAEG NKRQLHTQEA LDALDYKYYD TYKTPYTSGV
NKRISLVQAE YFTTNKFELD QPLGLDYAKL DSFVIHIFTK GQGHLKYGDG EEAVKMGDVY
LLPATMKQIQ IVPDGKLELL EVYVEA
//
