ID L8JR06_9BACT Unreviewed; 529 AA.
AC L8JR06;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=C900_04609 {ECO:0000313|EMBL:ELR69762.1};
OS Fulvivirga imtechensis AK7.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Fulvivirgaceae;
OC Fulvivirga.
OX NCBI_TaxID=1237149 {ECO:0000313|EMBL:ELR69762.1, ECO:0000313|Proteomes:UP000011135};
RN [1] {ECO:0000313|EMBL:ELR69762.1, ECO:0000313|Proteomes:UP000011135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK7 {ECO:0000313|EMBL:ELR69762.1,
RC ECO:0000313|Proteomes:UP000011135};
RA Nupur N., Khatri I., Kumar R., Subramanian S., Pinnaka A.;
RT "Genome assembly of Fulvivirga imtechensis AK7.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELR69762.1}.
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DR EMBL; AMZN01000068; ELR69762.1; -; Genomic_DNA.
DR RefSeq; WP_009581798.1; NZ_AMZN01000068.1.
DR AlphaFoldDB; L8JR06; -.
DR STRING; 1237149.C900_04609; -.
DR eggNOG; COG0827; Bacteria.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000011135; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000011135};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 153..250
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 529 AA; 60121 MW; 6BAD3A009D874A78 CRC64;
MSVVQPDVAT ILKDTPTVFS ELLASSYSES VNKELKKDRG QFFTPRQLAT FMASLASIKP
NIDLIRILDP GCGTLTLTCA LVQRIVELNP SIRAIEVDAY DTDPSLCTLI DDVISVADQW
GRKQDVEINI RYIQEDFILA NRAAIQNNDQ NGRYDIVISN PPYFKIGKQD ARLEVFKDAL
HGQQNIYGLF LLASLKLLKE GGELIYLIPR SFTSGLYFQS FREQFLSFAT LEHIHIFGSR
AESFKKDNVL QENIILKALK QKSDASRVVR ISHSAGVNEA RVDEARQYDE ATLIQDHGQS
NIIHLPINDL EEFAIKVFRQ WHNTLECYGM KVSTGPVVPF RSAALLASKR SPGSKLVPLI
WMHNCLKMKL DLSVIKKDKQ QWILDNRKSN SKTLENKNYV LLRRFSSKDD EYKLVATPIF
ANGLGYSRIG IENHLNYLHK PDGELERVEA LGLSVLYNST LFEAYFRSFS GNTQISATEL
NKTPMPPLEL IVEIGKEYQR LSLEGIEGID DIVERVLNLK RYKDARWIK
//
