ID L8N0T6_9CYAN Unreviewed; 1119 AA.
AC L8N0T6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=Pse7429DRAFT_2395 {ECO:0000313|EMBL:ELS32345.1};
OS Pseudanabaena biceps PCC 7429.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Pseudanabaenales;
OC Pseudanabaenaceae; Pseudanabaena.
OX NCBI_TaxID=927668 {ECO:0000313|EMBL:ELS32345.1, ECO:0000313|Proteomes:UP000011201};
RN [1] {ECO:0000313|EMBL:ELS32345.1, ECO:0000313|Proteomes:UP000011201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7429 {ECO:0000313|EMBL:ELS32345.1,
RC ECO:0000313|Proteomes:UP000011201};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00169}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELS32345.1}.
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DR EMBL; ALWB01000099; ELS32345.1; -; Genomic_DNA.
DR RefSeq; WP_009627531.1; NZ_ALWB01000099.1.
DR AlphaFoldDB; L8N0T6; -.
DR PATRIC; fig|927668.3.peg.2858; -.
DR Proteomes; UP000011201; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 3.
DR PANTHER; PTHR43047:SF79; HISTIDINE KINASE; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 3.
DR SMART; SM00448; REC; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 2.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 3.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ELS32345.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000313|EMBL:ELS32345.1}.
FT DOMAIN 16..130
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 166..206
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 240..292
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 293..363
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 366..418
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 592..664
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 734..970
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1000..1116
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 1049
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1119 AA; 125512 MW; AAB30DA24E37E4E4 CRC64;
MKNIGNLKRS NIPTTKILLV EDDLDDRLFF VQASEQVGLF YDYVMAASFT EAIAILSQHE
FAIAIVKSQL RDGEASQLLP ILQNINCPCI ITITNGEEET ATKLIAQGSA NYLIRDSDRY
YLKMLPAIIK ATISSHQTIV KLQEQNQALN IELQERIAAE KNLRDREDRY QQILDSIPDL
ILVKESGSRV VWGNKTFRDF YGISLECLKE NIETQFNFPF DTRQYICDDN FVFSTGQTLH
ISEESATRRD GSVRLMSTIK TPIFDEDGEV RKIVVISHDI TARKEATNSL QESERRFKTL
ATVVPVGIFR TDKNGNCIYV NERWSEIAGL SLEEALGEGW TTALHPDDRD KINNEWYLSA
QQNRPFKLEY RFLRKDGSTS WVLGQSLAET DLSGQIFGYV GTITDISDRR KAELTLQKLV
EGTAALTGLE FFPAVVSHIA EALAIPFVSV TELIGDHLHT LSFWAKGSLQ PSIAYPVRDT
PCEYVLKDGE FYCESQLQTY FFNDPYLAEM QADSYLGIAL KDNLGNVIGN LCIIDTQPLD
KSKYNESIAI LRIFGARVAA ELERKAATEA LYRLNQDLEI RVERRTQALQ ESEIRFRRMF
DSNVVGMLFA DFDGNILDAN DRFLQMIGYS REEFNTGKIF WHNLTPPEHV PADYAAMGKL
MEHGFIHPWE KEYYRKDGSR IPVLIGAAFL PGTENQTICV VIDISDRKQY ETQLKQTNAE
LAIATRLKDE FLANMSHELR TPLNAILGMT ESLQEEVFGS INENQKKSLK LIENSGFHLL
KLINDILDLA KIESGQVELD LASSNIEVLC QSSLAFIKQQ SHKKHIQIET KISPDLPNVS
IDERRILQVL INLLSNAVKF TPEGGRIVLE VSDRQQATLN HSDQTVEVPS LQKYLQIKVI
DTGIGISPEN IDKLFQPFIQ IDSALNRQYE GTGLGLSLVK RIVELHGGQV SLVSEVGVGS
SFTITLPCAD CQIASPAPET QPEALTATDE NGSEFKNPFK ILLVDDNEAN LMTVASYLSA
KGYDMILATN GEESITLAQL QAPDLILMDI QMPGTNGLET IKQMRQIPSL ANQPIIALTA
LTMQGDREKC IAAGATEYLA KPVKLRQLVL TIQQLQTAS
//
