ID L8WV07_THACA Unreviewed; 751 AA.
AC L8WV07;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=L-ornithine N(5)-monooxygenase {ECO:0000256|ARBA:ARBA00018612};
DE EC=1.14.13.196 {ECO:0000256|ARBA:ARBA00012881};
DE AltName: Full=L-ornithine N(5)-oxygenase {ECO:0000256|ARBA:ARBA00030351};
GN ORFNames=AG1IA_05348 {ECO:0000313|EMBL:ELU40632.1};
OS Thanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus)
OS (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=983506 {ECO:0000313|EMBL:ELU40632.1, ECO:0000313|Proteomes:UP000011668};
RN [1] {ECO:0000313|EMBL:ELU40632.1, ECO:0000313|Proteomes:UP000011668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG-1 IA {ECO:0000313|Proteomes:UP000011668};
RX PubMed=23361014; DOI=10.1038/ncomms2427;
RA Zheng A., Lin R., Xu L., Qin P., Tang C., Ai P., Zhang D., Liu Y., Sun Z.,
RA Feng H., Wang Y., Chen Y., Liang X., Fu R., Li Q., Zhang J., Yu X., Xie Z.,
RA Ding L., Guan P., Tang J., Liang Y., Wang S., Deng Q., Li S., Zhu J.,
RA Wang L., Liu H., Li P.;
RT "The evolution and pathogenic mechanisms of the rice sheath blight
RT pathogen.";
RL Nat. Commun. 4:1424-1424(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC NAD(+); Xref=Rhea:RHEA:41512, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:46911, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC ChEBI:CHEBI:78275; EC=1.14.13.196;
CC Evidence={ECO:0000256|ARBA:ARBA00001398};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC NADP(+); Xref=Rhea:RHEA:41508, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:46911, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:78275; EC=1.14.13.196;
CC Evidence={ECO:0000256|ARBA:ARBA00001847};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELU40632.1}.
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DR EMBL; AFRT01001369; ELU40632.1; -; Genomic_DNA.
DR AlphaFoldDB; L8WV07; -.
DR STRING; 983506.L8WV07; -.
DR HOGENOM; CLU_020931_2_0_1; -.
DR OMA; FTNELFY; -.
DR Proteomes; UP000011668; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:ELU40632.1};
KW Oxidoreductase {ECO:0000313|EMBL:ELU40632.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011668}.
FT REGION 390..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 81470 MW; 83E814CC17457912 CRC64;
MIAIAIRLWG SISDMRPPEF LPGDTSLSRT RSPYLRFRVK YQWSSDVVIS SSGVRLARES
SPPSSVNHVL PRLHMLSAPH SPDATPTMAS SRNIPHDPCN QLPCLGGKLA TWVSHLHLPF
TLSDYPHLLD NSHPSLLAPT RPSPEFSTMA TNPIHETSSI PGVDVASKGP NYNERYAGNE
FPEVYDLLGI GFGPANLAIT VALLELWDQH KAAGTEPNIN NACFIERHPR FSWHPGMLLP
GSRMQISFLK DLATLRNPAS KFTFLSYLHA HGRLPAFINR NADTPTRREY ADYMAWAATR
VRELGGEALR IRYGEDVVSV QSLDGGKTVT VTSRVRETNE VRIRNAKTLI IAPGGTARIP
KILAPYADHP RVMHTSSYVQ RAASLIKAAV ESTGSSRSPS PAGSDSSRLS GLTTARALRI
AVLGSGQSSA EVLLDLRSRL AGIPIEGEGP QEHQLDMIIR KGSLKPSDDS PFLHTDDKPF
IATDKAFKLP SAARAWLRAE YAGTNYGVVN PRTIDALYEE VYAQKVDDAA ESRPLGGVSA
PDGTRVRINI LSYQDTAHLS VSGSEMSNEP TFSIRLRHLL TGDEHDRGYD AIILGTGYER
QSWMRLFGQG ESKDVAPLSE VFGLTSLAPI RLLPVVEDEV TKPVTSLSKL DVAEAIAAKV
QGSQPLTPPR SGATTPPSPA ESTGSTLAEG VPPPSVRITR AYRLLPVEQH SNFTARVYVQ
GCAESSHGLS DTLLSVIGPR SGEVVADMVS A
//
