ID L8Y7N1_TUPCH Unreviewed; 902 AA.
AC L8Y7N1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Musculoskeletal embryonic nuclear protein 1 {ECO:0000256|ARBA:ARBA00018401};
GN ORFNames=TREES_T100010305 {ECO:0000313|EMBL:ELV10371.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV10371.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
CC -!- SIMILARITY: Belongs to the MUSTANG family.
CC {ECO:0000256|ARBA:ARBA00005390}.
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DR EMBL; KB367803; ELV10371.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y7N1; -.
DR STRING; 246437.L8Y7N1; -.
DR eggNOG; ENOG502QPS2; Eukaryota.
DR InParanoid; L8Y7N1; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:InterPro.
DR GO; GO:0035988; P:chondrocyte proliferation; IEA:InterPro.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR GO; GO:0042246; P:tissue regeneration; IEA:InterPro.
DR CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR031394; MUSTN1.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF119; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF15682; Mustang; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 58..187
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 313..496
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 100520 MW; 269BB87A8AB9D4CE CRC64;
MRLWALKAGA QDAPIKKKRP PVKEEDLKGA RGNLAKNQEI KSKTYQVMRE CVLVLLSLLP
VLQASSAQKN AIDIYSLTVD SKVSARFAHT VITSRVVNRA DTVQEATFQM ELPKKAFITN
FSMIIDGVTY PGNIKEKVVA QEQYSAAVAR GQSAGLVKVT GRKTEEFQVS VSVAPTTKVT
FELVYEELLQ RHLGVYELLL KVRPQQLVKH LQVDIHIFEP QGISFLETES TFMTDKLAEA
LTTSQNKTKA HIRFKPTLAQ QQKSPEKQDT VLDGSFIVRY DVNRTDSGGS IQIENGYFVH
YFAPEGLPAM PKNVIFVIDT SGSMSGRKIQ QTREALIKIL DDLKPKDQFN LITFSREVTQ
WEPLLVPASA QNVEKAKSYA KDIRAIGGTN INDAVLAAVD LLKSSNQKEL LPRGSVSLII
LLTDGEPTEG ETNPVKIQKN VREAIGDQFN LFCLGFGFDV IYPFLEKLAL DNGGLARRIY
EDSDSALQLQ DFYQEVANPL MTAVVFEYPS NVVEAVTQDN FRLLFKGSEI VVAGKLQEQN
PDVLSAKVNG QLHLQNITFQ AEASVAEQEE AFQGPKYIFH NFMERLWAYL TIQQQLERLI
LASDAERKAL ETQALNMSLK YSFVTPLTSM VVTKPEGQDQ SQVLEKPVED ESKHRPSHPA
MLAPVPTLSA PKVLTVPNPG RLPKSRLLLL ETTTAPSPPA PIQAHLFILP LPGQTVDRLC
VDIKQTQEPV NLISDPDQGI EVTGQYDAEK AELSWIQVTF KSPQLQVHAS PEHVVVTRNQ
KNSEYKWKET LFSVMPSLKM TMDQTGLLLL SAPDKVTIGL LSWDGPGKGI RLLLRDTDRF
SSRVGGTLGQ FYQEVLWEAL AAETDRRTLR VQGNDYSATS ELKLDYQEGP PGTEMACWTV
EL
//
