ID L8YEL6_TUPCH Unreviewed; 383 AA.
AC L8YEL6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Ras-related protein Rap-2 {ECO:0000256|RuleBase:RU367057};
GN ORFNames=TREES_T100006888 {ECO:0000313|EMBL:ELV13524.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13524.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Small GTP-binding protein which cycles between a GDP-bound
CC inactive and a GTP-bound active form. {ECO:0000256|RuleBase:RU367057}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00023421};
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004238}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004238}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004238}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004523, ECO:0000256|RuleBase:RU367057}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004523, ECO:0000256|RuleBase:RU367057};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004523,
CC ECO:0000256|RuleBase:RU367057}.
CC -!- PTM: Palmitoylated. {ECO:0000256|RuleBase:RU367057}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000256|RuleBase:RU367057}.
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DR EMBL; KB361132; ELV13524.1; -; Genomic_DNA.
DR AlphaFoldDB; L8YEL6; -.
DR STRING; 246437.L8YEL6; -.
DR eggNOG; KOG2494; Eukaryota.
DR InParanoid; L8YEL6; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; IEA:UniProtKB-UniRule.
DR GO; GO:0032486; P:Rap protein signal transduction; IEA:UniProtKB-UniRule.
DR CDD; cd04176; Rap2; 1.
DR Gene3D; 3.30.1370.210; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041840; Rap2.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR000571; Znf_CCCH.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR12675; MUSCLEBLIND-LIKE PROTEIN; 1.
DR PANTHER; PTHR12675:SF3; MUSCLEBLIND-LIKE PROTEIN 3; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF14608; zf-CCCH_2; 4.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SMART; SM00356; ZnF_C3H1; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
DR PROSITE; PS50103; ZF_C3H1; 4.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|RuleBase:RU367057};
KW GTP-binding {ECO:0000256|RuleBase:RU367057};
KW Lipoprotein {ECO:0000256|RuleBase:RU367057};
KW Membrane {ECO:0000256|RuleBase:RU367057};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Methylation {ECO:0000256|RuleBase:RU367057};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367057};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139, ECO:0000256|RuleBase:RU367057};
KW Prenylation {ECO:0000256|RuleBase:RU367057};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 14..42
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 48..74
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 110..138
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 146..172
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 14..42
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 48..74
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 110..138
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 146..172
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 383 AA; 43561 MW; 148B7316F65739BD CRC64;
MTAVNLALIR DTNWLTLEVC REFQRGTCSR ADADCKFAHP PRVCHVENGR VVACFDSLKG
RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTVAAMFAQ QMQLMLQNAQ MPSFVCREFQ
RGNCTRGEHD CRYAHPTDVS MIEASDNTVT ICMDYIKGRC SREKCKYFHP PAHLQAKLKA
AHHQMNHSAA TAMELVKVRL MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY
LIEIEVDSSP SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVYQQSF QDIKPMRDQI
VRVKRYEKVP LILVGNKVDL EPEREVMSSE GRALAQEWGC PFMETSAKSK SMVDELFAEI
VRQMNYSSLP EKQDQCCTTC VVQ
//
