ID L9JBT3_TUPCH Unreviewed; 1115 AA.
AC L9JBT3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Protein smoothened {ECO:0000256|ARBA:ARBA00035037};
GN ORFNames=TREES_T100001058 {ECO:0000313|EMBL:ELW48030.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW48030.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; KB321076; ELW48030.1; -; Genomic_DNA.
DR AlphaFoldDB; L9JBT3; -.
DR STRING; 246437.L9JBT3; -.
DR eggNOG; KOG3577; Eukaryota.
DR InParanoid; L9JBT3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0009888; P:tissue development; IEA:UniProt.
DR CDD; cd15030; 7tmF_SMO_homolog; 1.
DR CDD; cd07451; CRD_SMO; 1.
DR CDD; cd03158; penumbra_like_LEL; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR005633; Ribosomal_uL23_N.
DR InterPro; IPR035683; SMO_7TM.
DR InterPro; IPR041771; SMO_CRD.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF35; SMOOTHENED HOMOLOG; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF03939; Ribosomal_L23eN; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 391..507
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 557..819
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 996..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1115 AA; 123723 MW; C079129594C8560E CRC64;
MARRPGAPAA YGEEFTFVSP LVKYLLFFFN MLFWVISMVM VAVGVYARLM KHAEAALACL
AVDPAILLIV VGVLMFLLTF CGCIGSLREN ICLLQTFSLC LTVVFLLQLA AGVLGFVFSD
KARGKVSEII NNAIVHYRDD LDLQNLIDFG QKKMVPNAKK EAPAPPKAEA KAEALKAKKA
ALKGVHSHKK KKIHTSPIFR RPKTLWLRKR PKHPGKSAPR RNKLDHSAVI KFPLTAQSAM
KKIEDNNTLV FVMDVKATST SCCGGISYKD WSLNMYFNCS EDNPSRERCS VPYSCCLPTP
NQAVINTMCG QGMQALDYLE ASKVIYTNGC IDKLVNWIHS NLFLLGGVAL GLAIPQLVGI
LLSQILVNQI KDQIKLQLYN QQHRADPCHC GRAAPCEPLR FNVCLGSALP YGATSTLLAG
DSDSQEEAHG KLVLWSGLRN APRCWAVIQP LLCAVYMPKC ENDRVELPSR TLCQATRGPC
AIVERERGWP DFLRCTPDHF PEGCPNEVQN IKFNSSGQCE APLVRTDNPK SWYEDVEGCG
IQCQNPLFTE AEHQDMHSYI ATFGAVTGLC TLFTLATFVA DWRNSNRYPA VILFYVNACF
FVGSIGWLAQ FMVGARREIV CRADGTMRLG EPTSNETLSC VIIFVIVYYA LMAGVVWFVV
LTYAWHTSFK ALGTTYQPLS GKTSYFHLLT WSLPFVLTVA ILAVAQVDGD SVSGICFVGY
KNYRYRAGFV LAPIGLVLIV GGYFLIRGVM TLFSIKSNHP GLLSEKAASK INETMLRLGI
FGFLAFGFVL ITFSCHFYDF FNQAEWERSF RDYVLCQANV TIGLPTKKPI PDCEIKNRPS
LLVEKINLFA MFGTGIAMST WVWTKATLLI WRRTWCRLTG QSDDEPKRIK KSKMIAKAFS
KRRELLQNPG QELSFSLHTV SHDGPVAGLA FDLNEPSADV SSAWAQHVTK MVARRGAILP
QDVSVTPVAT PVPPEEQANL WLVEAEISPE LEKRLGRKKK RRKRKKEVCP LVPPPELQHA
TPAPARSAVP RLPQLPRQKC LVATGSWGAG DSCRQGAWTL ISNPFCPEPS PLQDPFLPSA
PAPTAWAQGR RQGLGPIHSR INLMEAELMD ADSDF
//
