ID L9JC53_TUPCH Unreviewed; 411 AA.
AC L9JC53;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Vacuolar protein sorting-associated protein 18 like protein {ECO:0000313|EMBL:ELW48151.1};
GN ORFNames=TREES_T100000975 {ECO:0000313|EMBL:ELW48151.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW48151.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630}.
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DR EMBL; KB321070; ELW48151.1; -; Genomic_DNA.
DR AlphaFoldDB; L9JC53; -.
DR STRING; 246437.L9JC53; -.
DR InParanoid; L9JC53; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd16689; RING-H2_Vps18; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REGION 339..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 247..281
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 411 AA; 46930 MW; 1917833033041D13 CRC64;
MQDYERVVAY HCQHEAYEEA LAVLARHRDP QLFYKFSPIL IRHIPRQLVD AWIELGSRLD
ARQLIPALVN YSQGGEAQQV SQAIRYMEFC VNVLGETEQA IHNYLLSLYA RGQPASLLAY
LEQAGASPHR VHYDLKYALR LCAEHGHHRA CVHVYKVLEL YEEAVDLALQ VDVDLAKQCA
DLPEEDEELR KKLWLKIARH VVQEEEDVQT AMACLASCPL LKIEDVLPFF PDFVTIDHFK
EAICSSLKAY NHHIQELQRE MEEATASAQR IRRDLQELRG RYGTVEPQDK CATCDFPLLN
RPFYLFLCGH MFHADCLLQA VRPGLPAYKQ ARLEELQRKL GAAPPPTKGS ARAKEAEGGG
PTGGPSREQL KADLDELVAA ECVYCGELMI RSIDRPFIDP QRYEEEHLSW L
//
