ID L9JEI6_TUPCH Unreviewed; 507 AA.
AC L9JEI6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Arylsulfatase A {ECO:0000313|EMBL:ELW49000.1};
GN ORFNames=TREES_T100000886 {ECO:0000313|EMBL:ELW49000.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW49000.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; KB321007; ELW49000.1; -; Genomic_DNA.
DR RefSeq; XP_006157625.1; XM_006157563.2.
DR AlphaFoldDB; L9JEI6; -.
DR STRING; 246437.L9JEI6; -.
DR GeneID; 102480471; -.
DR KEGG; tup:102480471; -.
DR CTD; 410; -.
DR eggNOG; KOG3867; Eukaryota.
DR InParanoid; L9JEI6; -.
DR OrthoDB; 2913702at2759; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR42693:SF11; ARYLSULFATASE A; 1.
DR PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR Pfam; PF14707; Sulfatase_C; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..507
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003999177"
FT DOMAIN 21..345
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 507 AA; 53849 MW; CAB692A4364F5AE8 CRC64;
MGAQWALLLA WAAGLATALP PNIVLIFADD LGYGDLGSYG HPTSTTPNLD QLAAGGLRFT
DFYVPVSLCT PSRAALLTGR LPVRSGLYPG VLEPSSRGGL PLEEVTLAEV LAAQGYLTGM
AGKWHLGVGP EGVFLPPHQG FHRFLGIPYS HDQGPCQNLT CFPPATPCDG GCDQGLVPIP
LLANLSVEEQ PPWLPGLEAR YVAFARDLMA DAQREGRPFF LYYASHHTHY PQFSGHNFVG
RSGRGPFGDS LMELDAAVGA LMTAVGDLGL LGETLVIFTA DNGPETMRMS RGGCSGLLRC
GKGTTFEGGV REPAFAFWPG HIAPGVTHEL ASSLDLLPTL AALSGAPLPN VTLDGTDLSP
LLLGTGKSPR QSLFFYPAYP DEVHGVFAVR SGKYKAHFFT QGSVHSDTTA DPTCHASSPL
TAHDPPLLYN LSEDPGENYN LLEDLAEVSP EVVETLKQLQ LLKAQFDAAM TFGPSEMSRG
KDPGLQICCQ PSCTPHPACC HCPSPHP
//
