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Database: UniProt
Entry: L9K0M1_TUPCH
LinkDB: L9K0M1_TUPCH
Original site: L9K0M1_TUPCH 
ID   L9K0M1_TUPCH            Unreviewed;       724 AA.
AC   L9K0M1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   05-JUL-2017, entry version 13.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TREES_T100004502 {ECO:0000313|EMBL:ELW54977.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW54977.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB320933; ELW54977.1; -; Genomic_DNA.
DR   InParanoid; L9K0M1; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 3.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    365    389       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    410    428       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    504    522       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    534    557       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    628    651       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    657    680       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   724 AA;  82921 MW;  5F6964BD9C44A3BF CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAE LHHQQMADPD LLEESSSLLE
     PSEIGRGTPL RLGFVAGVIN RERIPTFERM LWRVCRGNVF LRQAEIENPL EDPVTGDYVH
     KSVFIIFFQG DQLKNRVKKI CEGFRASLYP CPETPQERKE MASGVNTRID DLQMVLNQTE
     DHRQRVLQAA AKNIRVWFIK VRKMKAIYHT LNLCNIDVTQ KCLIAEVWCP VTDLDSIQFA
     LRRGTEHSGS TVPSILNRMQ TNQTPPTYNK TNKFTCGFQN IVDAYGIGTY REINPAPYTI
     ITFPFLFAVM FGDFGHGILM TLFAVWMVLR ESRILSQKNE NEMFSTVFSG RYIILLMGVF
     SIYTGLIYND CFSKSLNIFG SSWSVRPMFT LSNWTEETLK GNPVLQLNPA ITGVFGGPYP
     FGIDPIWNIA TNKLTFLNSF KMKMSVILGI IHMLFGVSLS LFNHIYFKKP LNIYFGFIPE
     IIFMTSLFGY LVILIFYKWT AYDAHTSENA PSLLIHFINM FLFSYPESGN AMLYSGQFDF
     GDTMVHQAIH TIEYCLGCIS NTASYLRLWA LSLAHAQLSE VLWTMVIHIG LSVKSLAGGL
     ALFFIFAAFA TLTVAILLIM EGLSAFLHAL RLHWVEFQNK FYSGTGFKFL PFSFEHIREG
     KFDE
//
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