ID L9KIE1_TUPCH Unreviewed; 540 AA.
AC L9KIE1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Heat shock 70 kDa protein 13 {ECO:0000256|ARBA:ARBA00018765};
DE AltName: Full=Stress-70 protein chaperone microsome-associated 60 kDa protein {ECO:0000256|ARBA:ARBA00031426};
GN ORFNames=TREES_T100010869 {ECO:0000313|EMBL:ELW62269.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62269.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Has peptide-independent ATPase activity.
CC {ECO:0000256|ARBA:ARBA00002077}.
CC -!- SUBUNIT: Binds UBQLN2. {ECO:0000256|ARBA:ARBA00011671}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Microsome
CC {ECO:0000256|ARBA:ARBA00004144}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR EMBL; KB320831; ELW62269.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KIE1; -.
DR STRING; 246437.L9KIE1; -.
DR eggNOG; KOG0101; Eukaryota.
DR InParanoid; L9KIE1; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10237; HSPA13-like_NBD; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 4.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR042048; HSPA13.
DR PANTHER; PTHR19375:SF169; HEAT SHOCK 70 KDA PROTEIN 13; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 2.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022848};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Stress response {ECO:0000313|EMBL:ELW62269.1}.
FT REGION 382..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 59137 MW; 04759171AC388379 CRC64;
MRHWQRLNGG SAPRVLTVDE VCTPLGALGF PATPEQKDYI SQEAEGLRAA WGWSLTSGTV
IPSLSGGTVM AGEMTILGSA VLTLLLAGYL AQQYLPLPTP KVIGIDLGTT YCSVGVFFPG
TGKVKVIPDE NGHISIPSMV SFTDSDVYVG YESLELADSN PQNTIYDAKR FIGKIFTPEE
LEAEIGRYPF KVLNKNGMVE FSVTSNETIT VSPEYVGSRL LLKLKEMAEE YLGMPVANAV
ISVPAEFDLK QRNSTIEAAN LAGLKILRVI NEPTAAAMAY GLHKADVFHV LVIDLGGGTL
DVSLLNKQGG MFLTRAMSGN NKLGGQDFNQ RLLQYLYKQI YQTYGFLPSR KEEIHRLRQA
VEMVKLNLTL HQTAQMSVLL TVEEKDRKEP QSSDSDLPKD RLSTADGHHV NSVLAPALSG
KKSGESHVLF ETEISRKLFD TLNEDLFQKI LVPIRQVLKE GHLEKTEIDE VVLVGGSTRI
PRIRQVIQEF FGKDPNTSVD PDLAVVTGVA IQAGIDGGSW PLQVSALEIP NKHLQKTNFN
//
