ID L9KIK8_TUPCH Unreviewed; 3221 AA.
AC L9KIK8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Huntingtin {ECO:0000313|EMBL:ELW62765.1};
GN ORFNames=TREES_T100000773 {ECO:0000313|EMBL:ELW62765.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62765.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: May play a role in microtubule-mediated transport or vesicle
CC function. {ECO:0000256|ARBA:ARBA00002907}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the huntingtin family.
CC {ECO:0000256|ARBA:ARBA00007153}.
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DR EMBL; KB320803; ELW62765.1; -; Genomic_DNA.
DR STRING; 246437.L9KIK8; -.
DR eggNOG; ENOG502QR1D; Eukaryota.
DR InParanoid; L9KIK8; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05605; STKc_GRK4_like; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR048412; Htt_bridge.
DR InterPro; IPR048413; Htt_C-HEAT_rpt.
DR InterPro; IPR048411; Htt_N_HEAT_rpt-1.
DR InterPro; IPR000091; Huntingtin.
DR InterPro; IPR028426; Huntingtin_fam.
DR InterPro; IPR024613; Huntingtin_N_HEAT_rpt-2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR10170:SF10; HUNTINGTIN; 1.
DR PANTHER; PTHR10170; HUNTINGTON DISEASE PROTEIN; 1.
DR Pfam; PF20925; Htt_bridge; 1.
DR Pfam; PF20927; Htt_C-HEAT; 2.
DR Pfam; PF12372; Htt_N-HEAT; 2.
DR Pfam; PF20926; Htt_N-HEAT_1; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR00375; HUNTINGTIN.
DR SMART; SM00315; RGS; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 27..116
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 123..497
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 498..563
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 946..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2712..2741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 152
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 3221 AA; 357707 MW; 03991758C99748F8 CRC64;
MALENIMANS LLLKARQEKN YSSLCNKQPI GRLLFRQFCD ANPNLKTYIE FLDAVEEYEV
ADDEDQRDCG LLILDRFFSD EVAAPLPKIP PNVVRECRSR LNQNHSKKVF EECTRQPVTK
NTFRHYRVLG KGGFGEVCAC QVRATGKMYA CKKLEKKRIK RRKGEAMALN EKRILEKVHS
RFVVSLAYTY ETKAALCLVL TIMNGGDLKF HIYNVGNPGF DEERAVFYAA EVCCGLEDLQ
KERIVYSPFP LGAFLEESFP EAACMYTFTF TGALEHLDCE RACGPRPAFA HVPSAVLSVG
DADDKLEDLD LEEANPFSFK EFLKSKSLGL SEDTGSSRVY SKEASRHSLG LGHHSPTMGD
LKPENILLDD LGHIRISDLG LAVEIPKGGT VQGRVGTVGY MAPEVIKNEK YTFSPDWWGL
GCLIYEMIQG HSPFKKFKEK VKREEVDRRV KMDTEEYSEK FSEDAKSICR MLLTKNPSER
LGCMGDGAAG VKQHPVFKNI NFSKLEANML DPPFCPDPHA VYCKDILDIG QFSVVKGVYL
DTTDDYFYAQ FVTGCVSIPW QNEMIESGCF EDINESENEK KLSLEFQKLL GIAMELFLLC
SDDAESDVRM VADECLNKVI KNGAPRSLRA ALWRFAELAH LVRPQKCRPY LVNLLPCLTR
TSKRPEESVQ ETLAAAVPKI MASFGNFAND NEIKVLLKAF IANLKSSSPT IRRTAAGSAV
SICQHSRRTQ YFYSWLLNVL LGLLVPVEEE HSTLLILGVL LTLRYLVPLL QQQVKDTSLK
GSFGVTRKEM EVSPSAEQLV QVYELTLHHT QHQDHNVVTG ALELLQQLLR TPPPELLQAL
TMAGGIGQLT VAKDESSGRS RSGSIVELIG KVLLGEEEAL DDDSESRSDV SSSAFAASVK
GEIGGELTAS SGVSTPGSAG HDIITEQPRS QHTLQADSVD LSSCDLTSAA TDGDEEDILS
HSSSQISAVP SDPAMDLNDG TQASSPISDS SQTTTEGPDS AVTPSDSSEI VLDGADSQYG
SMQIGQPQDE DEEAAGGLPD EASTAFRNSS IGMVLDGADS QYGSMQIGQP QDEDEEAAGG
LPDEASTAFR NSSIALQQAH LLKNMGHSRQ PSDSSVDKFV LRDEAAGPGD QENKPCRVKG
DIGQSTDDDS APLVHCVRLL SASFLLTGQK NALVPDRDVR VSVKALALSC VGAAVALHPE
SFFSKLYKVP LDTMEYPEEQ YVSDILNYID HGDPQVRGAT AILCGTLVCA ILNRSRFQVG
DWMGTIRTLT GNTFSLADCI PLLQKTLKDE SSVTCKLACT AVRHCVMSLC SSSYSELGLQ
LIIDLLALRN SAYWLVRTEL LETLAEIDFS NFLFHAVEVG GNICAYITAS APKSLRSSWT
SEEEANLGAT KQEEVWPALG ERSLVPMVEQ LFSHLLKVIN ICAHVLDEVA PGPAIKAALP
SLTNPPSLSP IRRKGKEKEP GEQASVPLSP KKGNEASTAS RQSDTSGPVT TSKSSSVGSF
YHLPSYLKLH DVLKATHANY KCVEEILGYL KSCFTREPMM ATVCVQQLLK TLFGTNLASQ
FDGLSSNPSK SQGRAQRLGS SSMRPGLYHY CFMAPYTHFT QALADASLRN MVQAEQEHDT
SGWFDVLQKV PTQLKTNLTS ITKNRTDKNA IHNHIRLFEP LVIKALKQYT TTTSVQLQKQ
VLDLLAQLVQ LRVNYCLLDS DQVFIGFVLK QFEYIEVGQF RESEAIIPNI FFFLVLLSYE
RYHSKQIIGI PKIIQLCDGI MASGRKAVTH AIPALQPIVH DLFVLRGTNK ADAGKELETQ
KEVVVSMLLR LIQYHQVLEM FILVLQQCHK ENEDKWKRLS RQIADIILPM LAKQQMHIDS
HEALGVLNTL FEILAPSSLR PVDMLLRSMF VTPNTMASVS TVQLWISGIL AILRVLISQS
TEDIVLSRIQ ELSFSSYLIS CPVINRLRDG DSNSTLEEHS EGKQMKNLPE ETFSRFLLQL
VGILLEDIVT KQLKVEMSEQ QHTFYCQELG TLLMCLIHIF KSGMFRRITA AATRLFTSDG
CDGSFYTLES LNARARSMIR THPALVLLWC QILLLVNYTD YRWWAEVQQT PKRHSLSSTK
LLSPQMSGEE EDSDLAAKLG MCNREIVRRG ALILFCDYVC QNLHDSEHLT WLIVNHVQDL
ISLSHEPPVQ DFISAVHRNS AASGLFIQAI QSRCENLSTP TTLKKTLQCL EGIHLSQSGA
VLTLYVDRLL CTPFRVLARM VDTLACRRVE MLLAANLQSS LAQLPVEELN RIQEYLQSSG
LAQRHQRLYS LLDRFRLSLV QDSASPSPPI TSHPLDGDGH MSLETVSPDR DWYIRLVKSQ
CWTRSDSALL EGAELVNRIP AEDMSAFMMN SALSWHLIHQ QIPLSLDLQA GLDCCCLALQ
LPGLWSVVSS TEFVTQACSL IHCVRFILEA NPKCVTMACE MVAEMVESLQ SVLALGHSRN
SSMPAFLTSV LRNIVISLAR LPLVNSYTRV PPLVWKLGWS PKPGGDFGTA FPEIPVEFLQ
EKEVFKEFIY RINTLGWTSR TQFEETWATL LGVLVTQPLV MEQEESPPEE DTERTQINVL
AVQAITSLVL SAMTVPVAGN PAVSCLEQQP RNKPLKALDT RFGRKLSIIR GIVEQEIQAM
VSKRENIATH HLYQAWDPVP SLSPATTGTL ISHDKLLLQI NPERELGNMS YKLGQVSIHS
VWLGNNITPL REEEWDEEEE EEADVPAPSS PPTSPVNSRK HRAGVDIHSC SQFLLELYSR
WILPSSSAKR TPVILISEVV RSLLVVSDLF TERSQFEMMY STLTELRRVH PSEDEILVQY
LVPATCKAAA VLGMDKAVAE PVSRLLESTL RSSYLPSRIA ALHGALYVLE CDLLDDTAKQ
LIPVLSDYLL SNLKGVAHCV NIHSQQHVLV MCATAFYLIE NYPLDVGPEF SASVIQMCGV
MLSGSEESTP SIVYHCALRG LERLLLSEQL SRLDAESLVK LSVDRVNVHS PHRAMAALGL
MLTCMYTGKE KISPGRTSDP NPAAPDSESV IVAMERVSVL FDRIRKGFPC EARVVARILP
QFLDDFFPPQ DVMNKVIGEF LSNQQPYPQF MATVVYKVFQ TLHSTGQSSM VRDWVMLSLS
NFTQRTPVAM AMWSLSCFFV SASTSPWVSA ILPHIISRMG KLEQVDVNLF CLVATDFYRH
QIEEELDRRA FQSVFEVVAA PGSPYHRLLT CLRNVHKVAT C
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