ID L9KJC8_TUPCH Unreviewed; 541 AA.
AC L9KJC8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Dynein regulatory complex subunit 4 {ECO:0000256|ARBA:ARBA00021301};
DE AltName: Full=Growth arrest-specific protein 8 {ECO:0000256|ARBA:ARBA00031568};
GN ORFNames=TREES_T100001684 {ECO:0000313|EMBL:ELW62861.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62861.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the DRC4 family.
CC {ECO:0000256|ARBA:ARBA00009859}.
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DR EMBL; KB320797; ELW62861.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KJC8; -.
DR STRING; 246437.L9KJC8; -.
DR eggNOG; ENOG502QQDA; Eukaryota.
DR InParanoid; L9KJC8; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0048870; P:cell motility; IEA:InterPro.
DR InterPro; IPR039308; GAS8.
DR InterPro; IPR025593; GAS8_dom.
DR PANTHER; PTHR31543; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR31543:SF0; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13851; GAS; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 285..483
FT /note="Growth arrest-specific protein 8"
FT /evidence="ECO:0000259|Pfam:PF13851"
FT REGION 65..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 311..411
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 541 AA; 62979 MW; B28162983633F979 CRC64;
MCVMLGAGWP SSCFGRITTG AQDDLRQVTQ VGKQLLEKEV LEKAGVVELL GSGPSTEKST
YEEFAPKKKG KKGKAKGNPI VDGLAPEDMS KEQVEEHIGR IREELDRERE ERNYFQLERD
KIHTFWEITR RQLEEKKAEL RNKDREMEEA EERHQVEIKV YKQKVKHLLY EHQNNLTEMK
AEGTVVMKLA QKEHRTQEGA LRKDMRALKV ELKEQELASE VVVKNLRLKH TEEITKMRSD
FERQVREIEA KYDKKMKMLR DELDLRRKTE VHEVEERKNG QISTLMQRHE EAFTDIKNYY
NDITLNNLAL INSLKEQMED MRKKEEHLER EMAEVATQNK RLADPLQKAR DEMSEMHKKL
GNYERDKQIL VCTKARLKVT EKELRDLQWE HEVLEQRFIQ VQQERDELYR KFTTAIQEVQ
QKTGFKNLVL ERKLQALSAT AEKREVQLNE VLAASNLDPT ALTLVSRKLE DVLESKNNTI
KDLQYELARV CKAHNDLLHT YEAKLLAFGV PLDNVGFKPL ETAVVGQTLG QGPAGLVGTP
T
//
