ID L9KJW9_TUPCH Unreviewed; 1026 AA.
AC L9KJW9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=E3 ubiquitin-protein ligase RFWD3 {ECO:0000313|EMBL:ELW63013.1};
GN ORFNames=TREES_T100001769 {ECO:0000313|EMBL:ELW63013.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW63013.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320797; ELW63013.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KJW9; -.
DR STRING; 246437.L9KJW9; -.
DR eggNOG; KOG0192; Eukaryota.
DR InParanoid; L9KJW9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd21037; MLKL_NTD; 1.
DR CDD; cd16450; mRING-C3HGC3_RFWD3; 1.
DR Gene3D; 1.20.930.20; Adaptor protein Cbl, N-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036537; Adaptor_Cbl_N_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR037381; RFWD3.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16047:SF7; E3 UBIQUITIN-PROTEIN LIGASE RFWD3; 1.
DR PANTHER; PTHR16047; RFWD3 PROTEIN; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 202..467
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 611..655
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 495..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 693..727
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 503..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 115069 MW; 1D102983F43B5DD9 CRC64;
MNILGQIISL GQLIYTQCEK MNYCQTQCQR LGSRVRGLLS PLQMLQARGE QNLPKEITAA
LDRFHAVLKE TQRQVDKFSS KSSVWKFIAA GQNKILFKDV NKNLSDVWEQ LSLLLQVHLH
LSVSTISYGA SWLQEDQEDA EKDRQNFPNE NNIKALLRQL EVNTNEIKEA LRAWLKLNSL
PKSRQEVLQV KIKEIKKEDL SGAPWRLLRE NAFSTLYKGE YHKAPVAIKV FNKLPNRSIG
IVRYTFNEEV STMKKFDSPN ILRVFGICID ETVTPPQFSI VMEHCELGTL RELLDKKKDL
KYGERFLLVL GAARGLYRLH HTEVPVLHRN ISSSSFLVTE GYHVKLAGFE LSKTQSSIRQ
ETKGKKIEKV RPTAYVSPQG LENLFHKYDI KAEIYSFGIV LWEIVTGKIP FEGYDSEKIR
QLVAVDRQQE PLGDDCPLEL QEVIDECRAY EPSERPSVEG RDRSSFSEKL SPEVTVGGGI
FRVLRRPPQL GWASEPGRGF LASDMQASSS SVSDSDSSGE YEEAVGQAEE PGAVIVEDMQ
ASSSSVSDSD SSGEYEEAVG QAEEPGAVIV EGGNPAEQEV TRIDEDKTLP KQSPQKSSPV
ASADEEEADT CTICLEQWTN AGDHRLSALR CGHLFGYRCI SKWLKGQARK CPQCNKKAKH
NDIVVLYART LRALDTTEQE RMKSAMQKEQ TLRRQAELES AQCRLQLQVL TDECTRLHSR
VQDLQKLIVQ HRDQILQQTG GSPTHILNCL PPSQRQHRYH LQKTFPVSQT GNCRIMAYCD
SLSCLVVSQP SPEASFLPGF GVKMLSTANM KSSQYIPMHG KQIRGLAFSS RSKGLLLSAS
LDNTVKLTRC PLVSLSYIPR AASPTFPCGG LLAGTLEGAS FWELKMGFSH WPHVLPLEPG
GCVDFQTESS TRHCLVTYRP DKNHNTIRSV LMEMSYRLND VGETTCSCYP VQTFLGGPTC
KLLTKSAIFQ SPENNGSILL WDAGSGSLLQ DLKTDQPVLD VCPFEVNSSS YLATLTEKMV
HIHRWE
//
