ID L9KYS3_TUPCH Unreviewed; 1198 AA.
AC L9KYS3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE Flags: Fragment;
GN ORFNames=TREES_T100003964 {ECO:0000313|EMBL:ELW67858.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67858.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KB320598; ELW67858.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KYS3; -.
DR STRING; 246437.L9KYS3; -.
DR eggNOG; KOG0923; Eukaryota.
DR InParanoid; L9KYS3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17974; DEXHc_DHX16; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ELW67858.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 566..730
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 755..928
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 52..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 234..261
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 387..414
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 52..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELW67858.1"
SQ SEQUENCE 1198 AA; 137088 MW; 3C36EE5B88B427D4 CRC64;
EELVQRLRDT DALDLSGPAR DFALRLWNKV PRKTVLEKPA RAAEREARAL LEKNRSYKLL
EDSEESSEET VGRAGSSLQK KRKKRKHLRK KRLEEEEDEE EEEASEKGKR KAGESKQLTE
KPESEDEWER TERERLLDLE ERDAFAERVR QRDKDRTRNV LERSDKKVRG VACAVLPGSL
VESGIAGVAG IRVPGKTRGA AWSVLTAVAY EEAQKRLKMA EEDRKAMVPE LRKKSRREYL
AKREREKLED LEAELADEEF LFGDVQLSRH ELRELKYKRR VRDLAREYRA AGEQEKLEAT
NRYHMPKETR GQPARAVDLV EEESGAPGEE QRRWEEARLG AASLKFGARD AASQEPKYQL
VLEEEETIEF VRATQLQGDE VPELRKKSRR EYLAKREREK LEDLEAELAD EEFLFGDVQL
SRHELRELKY KRRVRDLARE YRAAGEQEKL EATNRYHMPK ETRGQPARAV DLVEEESGAP
GEEQRRWEEA RLGAASLKFG ARDAASQEPK YQLVLEEEET IEFVRATQLQ GDEEPSAPPS
TQAQQKESIQ AVRRSLPVFP FREELLAAVA NHQVLIIEGE TGSGKTTQIP QYLFEEGYTE
KGMKIACTQP RRVAAMSVAA RVAREMGVKL GNEVGYSIRF EDCTSERTVL RYMTDGMLLR
EFLSEPDLAS YSVVMVDEAH ERTLHTDILF GLIKDVARFR PELKVLVASA TLDTARFSTF
FDDAPVFRIP GRRFPVDIFY TKAPEADYLE ACVVSVLQIH VTQPPGDILV FLTGQEEIEA
ACEMLQDRCR RLGSKIRELL VLPIYANLPS DMQARIFQPT PPGARKVVVA TNIAETSLTI
EGIIYVLDPG FCKQKSYNPR TGMESLTVTP CSKASANQRA GRAGRVAAGK CFRLYTAWAY
QHELEETTVP EIQRTSLGNV VLLLKSLGIH DLMHFDFLDP PPYETLLLAL EQLYALGALN
HLGELTTSGR KMAELPVDPM LSKMILASEK YSCSEEILTV AAMLSVNNSI FYRPKDKVVH
ADNARVNFFL PGGDHLVLLN VYTQWAESGY SSQWCYENFV QFRSMRRARD VREQLEGLLE
RVEVGLSSCQ GDYVRVRKAI TSGYFYHTAR LTRSGYRTVK QQQTVFIHPN SSLFEQQPRW
LLYHELVLTT KEFMRQVLEI ESSWLLEVAP HYYKAKELED PHAKKMPKKI GKTREELG
//
