ID L9L3I9_TUPCH Unreviewed; 525 AA.
AC L9L3I9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Neutrophil cytosol factor 2 {ECO:0000313|EMBL:ELW69745.1};
GN ORFNames=TREES_T100002689 {ECO:0000313|EMBL:ELW69745.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW69745.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the NCF2/NOXA1 family.
CC {ECO:0000256|ARBA:ARBA00008051}.
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DR EMBL; KB320523; ELW69745.1; -; Genomic_DNA.
DR RefSeq; XP_014441550.1; XM_014586064.1.
DR AlphaFoldDB; L9L3I9; -.
DR STRING; 246437.L9L3I9; -.
DR eggNOG; KOG4225; Eukaryota.
DR InParanoid; L9L3I9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:InterPro.
DR GO; GO:0045730; P:respiratory burst; IEA:InterPro.
DR CDD; cd06406; PB1_P67; 1.
DR CDD; cd12046; SH3_p67phox_C; 1.
DR CDD; cd11871; SH3_p67phox_N; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR034889; NCF2_SH3.
DR InterPro; IPR035546; p67phox_SH3_1.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034885; PB1_P67.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15175:SF3; NEUTROPHIL CYTOSOL FACTOR 2; 1.
DR PANTHER; PTHR15175; NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF13181; TPR_8; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 71..104
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 240..299
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 351..429
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 456..515
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 304..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 59494 MW; 339409E3F1820899 CRC64;
MSLAEAISLW NTGVLAADKK DWKGALDAFS AVQDPHSRIC FNVGCMHTIL GNMAEAEKAF
TKSISRDKHL AVAYFQRGML YHQIAKYDSA IKDLKEALTQ LRGNQLIDYK ILGLQFKLFA
CEVLYNIALM YAKKEEWKKA EEQLALATSM KSEPRHSRID KAMECIWKQK LYEPVVIPVG
RLFRPNERQV AQLVKKDYLG KATVVASVVD QDNFSGFAPL QPQVAEPPPR PKTPEIFRAL
EGEAHRVLFG FVPETSEELQ VMPGNIVFVL KKGSDNWATV MFNGQKGLVP CNYLEPVELR
IHPQQQPQEE MSPESDIPAP PSSSAPGRPQ LSPGQKQKEE LREVKLSVPM PYTLKVHYKY
TVVMETQLGL PYSQVRNLVS TKLELRPEHT QLSYRPRDSN ELVPLSEETM KDAWGQVKNY
CLTLWCENTV GDQGFPDEPE EREKSDAKHH TEPQLKEGSR VVALFSYEAT QPEDLDFLEG
DVILVLSKVN EEWLEGECKG KVGIFPKAFV EEYITTDLER TPRGV
//
