ID L9X504_9EURY Unreviewed; 1589 AA.
AC L9X504;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=C492_15401 {ECO:0000313|EMBL:ELY55673.1};
OS Natronococcus jeotgali DSM 18795.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natronococcus.
OX NCBI_TaxID=1227498 {ECO:0000313|EMBL:ELY55673.1, ECO:0000313|Proteomes:UP000011531};
RN [1] {ECO:0000313|EMBL:ELY55673.1, ECO:0000313|Proteomes:UP000011531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18795 {ECO:0000313|EMBL:ELY55673.1,
RC ECO:0000313|Proteomes:UP000011531};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELY55673.1}.
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DR EMBL; AOIA01000128; ELY55673.1; -; Genomic_DNA.
DR STRING; 1227498.C492_15401; -.
DR PATRIC; fig|1227498.3.peg.3020; -.
DR OrthoDB; 38162at2157; -.
DR Proteomes; UP000011531; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.70.98.10; -; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 2.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 2.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SMART; SM00560; LamGL; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ELY55673.1};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1081..1570
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
FT DOMAIN 1230..1358
FT /note="LamG-like jellyroll fold"
FT /evidence="ECO:0000259|SMART:SM00560"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1589 AA; 172558 MW; 30607724DDB10C2C CRC64;
MSGADEPAET EPVGRRLSTS RRRFLQATGM AALTSGAGVG AAAASDGSSP SRISPGAIDE
ATLRSYIDDP AVFEENHEPP HVTTTVPFES TEQAVAADVP YERLEDRFDR SPYFRLLDGD
WRFKRYENYA AVPDSHDDVD WDEIAVPSSW QARGYGQRIY ANTDLTWNHY DPPSDENPVE
EVPLENNPVG VYRRSFEVPA DWDGRRTHLH FGGVRQAYFV WVDGEYVGYH QGSMTPGEFD
VTDRVEAGGT HEVTVQVYRF SDGEAVEAQD MFRYSGIFRS VYLYATPRVR VRDFFVRTDL
DDDYEDATLR VDAELANDGG EPGEYELRGC LYALDSDGPR RGPPEETPGR GPPEDAPGRG
PRPGDAGDGP SEGPGRGPPG EGSAGREVAT LSGSAAVGAE GAHVSLETAV RDPEKWSAED
PTLYTLVLEL VPLEGDAPGE VLLEKVGFRA YEAERGALSS AWRVNGEPMN VRGVNRHETD
PDYGRHVPIE TLRTDFEVMK RFNVNSVRTS HYPNDPSFYR LADEYGIYVQ DEINVETHWW
EQMAANVDAF DEQILARWRR MVQRDKNHAS VFVYSTGNEA GTGPPHLAMA ADNLGEENAD
RIPATFEARH LSGADDADRV GEALDLEPRG VDTTRQLYHQ PNGGGWTIDY SDMLGPRYPM
PDGMVGEGDG SGLGDGERPV MMGEYNHAMG NSLGLIHEMW SEYVQPPVRR ARDGAGENDG
VLVGSPEVAG DGRVALEGGE YVEVRGAADV ASLETGGTVE VVVRDVDGAT PLVVADGYEL
SAADGEFEFA VGDASVAASI PDGDGRHTVA GVRADGELRL YVDGELAGVE GDSADGLEFG
GDLLIGGDPD ADGDVTLESV TLSGAAPDGE GYSSPGEPAL SYDFADLARD KSLQGGWIWD
WVNQDLNDET DDGEPFQFYH LEGPDGAFCL NGTLWSDRTP QPEMWELKKS HQPVGIAARA
LEDGELYVTN HFGFTDLSAL ETRWELAADD ETIDSGELDL EIAPGETRPV TVPFEAPDLV
PGAEYWLDVS VRLAEPTDYA DAGHEVAFEQ FAVPFDVPEP ETERAAAMPG LSVSESDGTI
AIEGDGFEYA FDSELGTLAS MEYDGTELLE RGPLLNAWRA PIMNEAQDWG GAQAPDWYEA
GLDDLRHVVE SVEVDRLEDS VARVAVEGFA EGAAVDGGLV TPDASPTGAD GALRGDPEIV
DGAAGAAVAL DGEDDYLEVG TPDALDFTET GFTVEVTFEG IDDADHGPLL AKGDYQYALK
TAGGDAFEFF VYDGDWVTLQ APIPETAREG WHTLAGVCDD DELRLYLDGE RLAVEDHAVE
SVDSSGAPVR IGQNADQDRY VETTVDAAAV YDAALDDETL ADGFDEPPES AVLWYDLDEF
EEADDEGNGP GFATRYAYRV FGTGEVVLDV ESDPNDRLRS AIGDWLPKVG VRLELPDSFG
EFEWYGRGPQ ETMPDRKWGV RVGRYSGSVD EQHVPYLPPQ DNGNKAETRW AAVANDDGVG
LAAVAHPEMH VNLEQYANLD EADHGYELEE RESVGLDLDH AVTGVGGTPT TPLPEYQVRP
EPMAFTVSLR PFADEDPMAL AKRRLPDAE
//
