ID LACA_STAA3 Reviewed; 142 AA.
AC Q2FET7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000255|HAMAP-Rule:MF_01555};
DE EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01555};
GN Name=lacA {ECO:0000255|HAMAP-Rule:MF_01555};
GN OrderedLocusNames=SAUSA300_2155;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01555};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01555}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000255|HAMAP-Rule:MF_01555}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC Rule:MF_01555}.
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DR EMBL; CP000255; ABD21643.1; -; Genomic_DNA.
DR RefSeq; WP_000974608.1; NZ_CP027476.1.
DR AlphaFoldDB; Q2FET7; -.
DR SMR; Q2FET7; -.
DR GeneID; 66840413; -.
DR KEGG; saa:SAUSA300_2155; -.
DR HOGENOM; CLU_091396_4_2_9; -.
DR OMA; KSIVDVW; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR HAMAP; MF_01555; LacA; 1.
DR InterPro; IPR004783; LacA.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR NCBIfam; TIGR01118; lacA; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR30345:SF5; GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNIT LACA; 1.
DR PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Isomerase; Lactose metabolism.
FT CHAIN 1..142
FT /note="Galactose-6-phosphate isomerase subunit LacA"
FT /id="PRO_1000068922"
SQ SEQUENCE 142 AA; 15395 MW; A52C4A7DBF30BE19 CRC64;
MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD VQSQEGNLGI
VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR MITMGSEIVG DTLAKNVVKG
FVEGKYDGGR HQIRVDMLNK MC
//
