ID LNX1_HUMAN Reviewed; 728 AA.
AC Q8TBB1; Q4W5K7; Q8N4C2; Q96MJ7; Q9BY20;
DT 28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 192.
DE RecName: Full=E3 ubiquitin-protein ligase LNX;
DE EC=2.3.2.27;
DE AltName: Full=Ligand of Numb-protein X 1;
DE AltName: Full=Numb-binding protein 1;
DE AltName: Full=PDZ domain-containing RING finger protein 2;
DE AltName: Full=RING-type E3 ubiquitin transferase LNX {ECO:0000305};
GN Name=LNX1; Synonyms=LNX, PDZRN2; ORFNames=UNQ574/PRO1136;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=11521506; DOI=10.1023/a:1010269908398;
RA Xie Y., Zhao W., Wang W., Zhao S., Tang R., Ying K., Zhou Z., Mao Y.;
RT "Identification of a human LNX protein containing multiple PDZ domains.";
RL Biochem. Genet. 39:117-126(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH CXADR.
RX PubMed=12468544; DOI=10.1074/jbc.m205927200;
RA Sollerbrant K., Raschperger E., Mirza M., Engstroem U., Philipson L.,
RA Ljungdahl P.O., Pettersson R.F.;
RT "The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the
RT PDZ domain-containing protein ligand-of-numb protein-X (LNX).";
RL J. Biol. Chem. 278:7439-7444(2003).
RN [7]
RP INTERACTION WITH NP9.
RX PubMed=15367597; DOI=10.1128/jvi.78.19.10310-10319.2004;
RA Armbruester V., Sauter M., Roemer K., Best B., Hahn S., Nty A., Schmid A.,
RA Philipp S., Mueller A., Mueller-Lantzsch N.;
RT "Np9 protein of human endogenous retrovirus K interacts with ligand of numb
RT protein X.";
RL J. Virol. 78:10310-10319(2004).
RN [8]
RP INTERACTION WITH MAGEB18 AND MAGEF1.
RX PubMed=20864041; DOI=10.1016/j.molcel.2010.08.029;
RA Doyle J.M., Gao J., Wang J., Yang M., Potts P.R.;
RT "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.";
RL Mol. Cell 39:963-974(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and
CC subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept
CC ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
CC thioester and then directly transfers the ubiquitin to targeted
CC substrates. Mediates ubiquitination of isoform p66 and isoform p72 of
CC NUMB, but not that of isoform p71 or isoform p65.
CC {ECO:0000250|UniProtKB:O70263}.
CC -!- FUNCTION: Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
CC {ECO:0000250|UniProtKB:O70263}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with the phosphotyrosine interaction domain of all
CC isoforms of NUMB (By similarity). Interacts with MAGEB18 and MAGEF1.
CC Interacts with the Coxsackievirus and adenovirus receptor CXADR.
CC Interacts with endogenous retrovirus K protein Np9. IGSF5/JAM4
CC interacts with isoform 2 through the second PDZ domain, other isoforms
CC may also interact with IGSF5/JAM4 (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8TBB1; P01023: A2M; NbExp=3; IntAct=EBI-739832, EBI-640741;
CC Q8TBB1; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-739832, EBI-11096309;
CC Q8TBB1; Q9BWD1: ACAT2; NbExp=3; IntAct=EBI-739832, EBI-1047273;
CC Q8TBB1; P12814: ACTN1; NbExp=3; IntAct=EBI-739832, EBI-351710;
CC Q8TBB1; Q08043: ACTN3; NbExp=3; IntAct=EBI-739832, EBI-2880652;
CC Q8TBB1; O43707: ACTN4; NbExp=3; IntAct=EBI-739832, EBI-351526;
CC Q8TBB1; Q96HD9: ACY3; NbExp=3; IntAct=EBI-739832, EBI-3916242;
CC Q8TBB1; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-739832, EBI-10173507;
CC Q8TBB1; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-739832, EBI-741181;
CC Q8TBB1; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-739832, EBI-11522760;
CC Q8TBB1; Q96BJ3: AIDA; NbExp=3; IntAct=EBI-739832, EBI-4401674;
CC Q8TBB1; Q13155: AIMP2; NbExp=8; IntAct=EBI-739832, EBI-745226;
CC Q8TBB1; P09972: ALDOC; NbExp=6; IntAct=EBI-739832, EBI-2952751;
CC Q8TBB1; Q96Q83: ALKBH3; NbExp=3; IntAct=EBI-739832, EBI-6658697;
CC Q8TBB1; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-739832, EBI-11954519;
CC Q8TBB1; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-739832, EBI-541426;
CC Q8TBB1; Q96GX9: APIP; NbExp=11; IntAct=EBI-739832, EBI-359248;
CC Q8TBB1; Q9BRG6: APOL4; NbExp=3; IntAct=EBI-739832, EBI-10296818;
CC Q8TBB1; P61204: ARF3; NbExp=3; IntAct=EBI-739832, EBI-641535;
CC Q8TBB1; P53365: ARFIP2; NbExp=3; IntAct=EBI-739832, EBI-638194;
CC Q8TBB1; Q8N5M1: ATPAF2; NbExp=11; IntAct=EBI-739832, EBI-1166928;
CC Q8TBB1; Q8WXE1: ATRIP; NbExp=3; IntAct=EBI-739832, EBI-747353;
CC Q8TBB1; P54253: ATXN1; NbExp=6; IntAct=EBI-739832, EBI-930964;
CC Q8TBB1; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-739832, EBI-4400025;
CC Q8TBB1; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-739832, EBI-10181188;
CC Q8TBB1; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-739832, EBI-11975051;
CC Q8TBB1; Q13490: BIRC2; NbExp=3; IntAct=EBI-739832, EBI-514538;
CC Q8TBB1; P53004: BLVRA; NbExp=5; IntAct=EBI-739832, EBI-7410441;
CC Q8TBB1; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-739832, EBI-2548012;
CC Q8TBB1; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-739832, EBI-10193358;
CC Q8TBB1; Q9H0C5: BTBD1; NbExp=3; IntAct=EBI-739832, EBI-935503;
CC Q8TBB1; Q9BXJ1: C1QTNF1; NbExp=3; IntAct=EBI-739832, EBI-750200;
CC Q8TBB1; Q9BXJ1-2: C1QTNF1; NbExp=3; IntAct=EBI-739832, EBI-11536642;
CC Q8TBB1; P35219: CA8; NbExp=6; IntAct=EBI-739832, EBI-718700;
CC Q8TBB1; Q9NP86: CABP5; NbExp=3; IntAct=EBI-739832, EBI-10311131;
CC Q8TBB1; A2RRN7: CADPS; NbExp=3; IntAct=EBI-739832, EBI-10179719;
CC Q8TBB1; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-739832, EBI-11530605;
CC Q8TBB1; P55212: CASP6; NbExp=3; IntAct=EBI-739832, EBI-718729;
CC Q8TBB1; Q86XM0: CATSPERD; NbExp=3; IntAct=EBI-739832, EBI-10260328;
CC Q8TBB1; P83916: CBX1; NbExp=3; IntAct=EBI-739832, EBI-78129;
CC Q8TBB1; Q9Y3M2: CBY1; NbExp=3; IntAct=EBI-739832, EBI-947308;
CC Q8TBB1; Q8NA61-2: CBY2; NbExp=7; IntAct=EBI-739832, EBI-11524851;
CC Q8TBB1; Q6UXH8-3: CCBE1; NbExp=3; IntAct=EBI-739832, EBI-12013534;
CC Q8TBB1; Q68D86: CCDC102B; NbExp=4; IntAct=EBI-739832, EBI-10171570;
CC Q8TBB1; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-739832, EBI-347573;
CC Q8TBB1; Q7Z6B0-2: CCDC91; NbExp=3; IntAct=EBI-739832, EBI-12012082;
CC Q8TBB1; O95273: CCNDBP1; NbExp=3; IntAct=EBI-739832, EBI-748961;
CC Q8TBB1; P32320: CDA; NbExp=9; IntAct=EBI-739832, EBI-9250559;
CC Q8TBB1; O14735: CDIPT; NbExp=3; IntAct=EBI-739832, EBI-358858;
CC Q8TBB1; P55273: CDKN2D; NbExp=3; IntAct=EBI-739832, EBI-745859;
CC Q8TBB1; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-739832, EBI-739624;
CC Q8TBB1; Q9P209: CEP72; NbExp=6; IntAct=EBI-739832, EBI-739498;
CC Q8TBB1; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-739832, EBI-742887;
CC Q8TBB1; Q6P2H3-3: CEP85; NbExp=3; IntAct=EBI-739832, EBI-12368239;
CC Q8TBB1; Q96Q77: CIB3; NbExp=3; IntAct=EBI-739832, EBI-10292696;
CC Q8TBB1; Q14011: CIRBP; NbExp=3; IntAct=EBI-739832, EBI-538850;
CC Q8TBB1; P49759-3: CLK1; NbExp=3; IntAct=EBI-739832, EBI-11981867;
CC Q8TBB1; P49760: CLK2; NbExp=8; IntAct=EBI-739832, EBI-750020;
CC Q8TBB1; P49761: CLK3; NbExp=3; IntAct=EBI-739832, EBI-745579;
CC Q8TBB1; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-739832, EBI-11522780;
CC Q8TBB1; P38432: COIL; NbExp=2; IntAct=EBI-739832, EBI-945751;
CC Q8TBB1; Q96FN4: CPNE2; NbExp=3; IntAct=EBI-739832, EBI-7097057;
CC Q8TBB1; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-739832, EBI-11523759;
CC Q8TBB1; Q8N4Y2-3: CRACR2B; NbExp=3; IntAct=EBI-739832, EBI-11982645;
CC Q8TBB1; O43186: CRX; NbExp=3; IntAct=EBI-739832, EBI-748171;
CC Q8TBB1; Q9NS75: CYSLTR2; NbExp=3; IntAct=EBI-739832, EBI-3843579;
CC Q8TBB1; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-739832, EBI-3867333;
CC Q8TBB1; O75553: DAB1; NbExp=5; IntAct=EBI-739832, EBI-7875264;
CC Q8TBB1; Q9H773: DCTPP1; NbExp=3; IntAct=EBI-739832, EBI-723569;
CC Q8TBB1; Q9BTE7: DCUN1D5; NbExp=3; IntAct=EBI-739832, EBI-3924013;
CC Q8TBB1; P35638: DDIT3; NbExp=3; IntAct=EBI-739832, EBI-742651;
CC Q8TBB1; Q92841: DDX17; NbExp=4; IntAct=EBI-739832, EBI-746012;
CC Q8TBB1; Q6P3S1-5: DENND1B; NbExp=3; IntAct=EBI-739832, EBI-12105346;
CC Q8TBB1; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-739832, EBI-398977;
CC Q8TBB1; Q05D60: DEUP1; NbExp=3; IntAct=EBI-739832, EBI-748597;
CC Q8TBB1; P49366: DHPS; NbExp=3; IntAct=EBI-739832, EBI-741925;
CC Q8TBB1; Q14565: DMC1; NbExp=3; IntAct=EBI-739832, EBI-930865;
CC Q8TBB1; G5E9A7: DMWD; NbExp=3; IntAct=EBI-739832, EBI-10976677;
CC Q8TBB1; Q9ULA0: DNPEP; NbExp=7; IntAct=EBI-739832, EBI-748356;
CC Q8TBB1; Q92785: DPF2; NbExp=3; IntAct=EBI-739832, EBI-359932;
CC Q8TBB1; Q14919: DRAP1; NbExp=3; IntAct=EBI-739832, EBI-712941;
CC Q8TBB1; Q9Y295: DRG1; NbExp=3; IntAct=EBI-739832, EBI-719554;
CC Q8TBB1; Q86UW9: DTX2; NbExp=3; IntAct=EBI-739832, EBI-740376;
CC Q8TBB1; Q68J44: DUSP29; NbExp=5; IntAct=EBI-739832, EBI-1054321;
CC Q8TBB1; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-739832, EBI-740680;
CC Q8TBB1; P63172: DYNLT1; NbExp=3; IntAct=EBI-739832, EBI-1176455;
CC Q8TBB1; Q96F86: EDC3; NbExp=3; IntAct=EBI-739832, EBI-997311;
CC Q8TBB1; Q96G04: EEF2KMT; NbExp=3; IntAct=EBI-739832, EBI-747840;
CC Q8TBB1; O95967: EFEMP2; NbExp=3; IntAct=EBI-739832, EBI-743414;
CC Q8TBB1; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-739832, EBI-2349927;
CC Q8TBB1; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-739832, EBI-1175354;
CC Q8TBB1; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-739832, EBI-750700;
CC Q8TBB1; P38919: EIF4A3; NbExp=3; IntAct=EBI-739832, EBI-299104;
CC Q8TBB1; Q15056: EIF4H; NbExp=4; IntAct=EBI-739832, EBI-748492;
CC Q8TBB1; Q8TC92: ENOX1; NbExp=4; IntAct=EBI-739832, EBI-713221;
CC Q8TBB1; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-739832, EBI-6255981;
CC Q8TBB1; Q96CN4: EVI5L; NbExp=3; IntAct=EBI-739832, EBI-749523;
CC Q8TBB1; Q9Y3B2: EXOSC1; NbExp=3; IntAct=EBI-739832, EBI-371892;
CC Q8TBB1; Q9NPD3: EXOSC4; NbExp=3; IntAct=EBI-739832, EBI-371823;
CC Q8TBB1; Q96B26: EXOSC8; NbExp=6; IntAct=EBI-739832, EBI-371922;
CC Q8TBB1; Q9NWS6: FAM118A; NbExp=4; IntAct=EBI-739832, EBI-8638992;
CC Q8TBB1; Q86V42: FAM124A; NbExp=3; IntAct=EBI-739832, EBI-744506;
CC Q8TBB1; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-739832, EBI-6658203;
CC Q8TBB1; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-739832, EBI-10175124;
CC Q8TBB1; P49327: FASN; NbExp=3; IntAct=EBI-739832, EBI-356658;
CC Q8TBB1; Q9NXK8: FBXL12; NbExp=3; IntAct=EBI-739832, EBI-719790;
CC Q8TBB1; O15409: FOXP2; NbExp=3; IntAct=EBI-739832, EBI-983612;
CC Q8TBB1; A1L4K1: FSD2; NbExp=3; IntAct=EBI-739832, EBI-5661036;
CC Q8TBB1; P51114-2: FXR1; NbExp=3; IntAct=EBI-739832, EBI-11022345;
CC Q8TBB1; P31150: GDI1; NbExp=6; IntAct=EBI-739832, EBI-946999;
CC Q8TBB1; P14136: GFAP; NbExp=3; IntAct=EBI-739832, EBI-744302;
CC Q8TBB1; O76003: GLRX3; NbExp=3; IntAct=EBI-739832, EBI-374781;
CC Q8TBB1; Q96IK5: GMCL1; NbExp=3; IntAct=EBI-739832, EBI-2548508;
CC Q8TBB1; O75496: GMNN; NbExp=3; IntAct=EBI-739832, EBI-371669;
CC Q8TBB1; Q9H4A5: GOLPH3L; NbExp=3; IntAct=EBI-739832, EBI-4403434;
CC Q8TBB1; Q92917: GPKOW; NbExp=5; IntAct=EBI-739832, EBI-746309;
CC Q8TBB1; O75791: GRAP2; NbExp=4; IntAct=EBI-739832, EBI-740418;
CC Q8TBB1; P62993: GRB2; NbExp=4; IntAct=EBI-739832, EBI-401755;
CC Q8TBB1; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-739832, EBI-717919;
CC Q8TBB1; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-739832, EBI-11978177;
CC Q8TBB1; Q7Z353: HDX; NbExp=3; IntAct=EBI-739832, EBI-1052734;
CC Q8TBB1; V9HW56: HEL-S-108; NbExp=3; IntAct=EBI-739832, EBI-10330141;
CC Q8TBB1; V9HWB8: HEL-S-30; NbExp=3; IntAct=EBI-739832, EBI-10215395;
CC Q8TBB1; V9HWF5: HEL-S-69p; NbExp=3; IntAct=EBI-739832, EBI-10330249;
CC Q8TBB1; P07686: HEXB; NbExp=3; IntAct=EBI-739832, EBI-7133736;
CC Q8TBB1; Q96MH2: HEXIM2; NbExp=5; IntAct=EBI-739832, EBI-5460660;
CC Q8TBB1; O00291: HIP1; NbExp=3; IntAct=EBI-739832, EBI-473886;
CC Q8TBB1; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-739832, EBI-2549423;
CC Q8TBB1; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-739832, EBI-740641;
CC Q8TBB1; P52597: HNRNPF; NbExp=3; IntAct=EBI-739832, EBI-352986;
CC Q8TBB1; P31943: HNRNPH1; NbExp=3; IntAct=EBI-739832, EBI-351590;
CC Q8TBB1; Q9NSC5: HOMER3; NbExp=6; IntAct=EBI-739832, EBI-748420;
CC Q8TBB1; Q8IX15-3: HOMEZ; NbExp=3; IntAct=EBI-739832, EBI-10172004;
CC Q8TBB1; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-739832, EBI-10961706;
CC Q8TBB1; P49639: HOXA1; NbExp=3; IntAct=EBI-739832, EBI-740785;
CC Q8TBB1; O75506: HSBP1; NbExp=10; IntAct=EBI-739832, EBI-748664;
CC Q8TBB1; O75031: HSF2BP; NbExp=3; IntAct=EBI-739832, EBI-7116203;
CC Q8TBB1; P42858: HTT; NbExp=6; IntAct=EBI-739832, EBI-466029;
CC Q8TBB1; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-739832, EBI-8638439;
CC Q8TBB1; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-739832, EBI-747204;
CC Q8TBB1; Q14005-2: IL16; NbExp=3; IntAct=EBI-739832, EBI-17178971;
CC Q8TBB1; Q8NBZ0: INO80E; NbExp=3; IntAct=EBI-739832, EBI-769401;
CC Q8TBB1; Q9BT40: INPP5K; NbExp=3; IntAct=EBI-739832, EBI-749162;
CC Q8TBB1; Q96PC2: IP6K3; NbExp=3; IntAct=EBI-739832, EBI-10990676;
CC Q8TBB1; Q9H1K1: ISCU; NbExp=3; IntAct=EBI-739832, EBI-1047335;
CC Q8TBB1; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-739832, EBI-1055254;
CC Q8TBB1; Q8IYT4: KATNAL2; NbExp=3; IntAct=EBI-739832, EBI-1044332;
CC Q8TBB1; Q719H9: KCTD1; NbExp=7; IntAct=EBI-739832, EBI-9027502;
CC Q8TBB1; Q8WZ19: KCTD13; NbExp=5; IntAct=EBI-739832, EBI-742916;
CC Q8TBB1; Q8NC69: KCTD6; NbExp=4; IntAct=EBI-739832, EBI-2511344;
CC Q8TBB1; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-739832, EBI-11954971;
CC Q8TBB1; Q7L273: KCTD9; NbExp=6; IntAct=EBI-739832, EBI-4397613;
CC Q8TBB1; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-739832, EBI-742808;
CC Q8TBB1; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-739832, EBI-3437878;
CC Q8TBB1; Q5T7B8-2: KIF24; NbExp=3; IntAct=EBI-739832, EBI-10213781;
CC Q8TBB1; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-739832, EBI-14069005;
CC Q8TBB1; Q53G59: KLHL12; NbExp=4; IntAct=EBI-739832, EBI-740929;
CC Q8TBB1; Q5T749: KPRP; NbExp=3; IntAct=EBI-739832, EBI-10981970;
CC Q8TBB1; P19012: KRT15; NbExp=5; IntAct=EBI-739832, EBI-739566;
CC Q8TBB1; P08779: KRT16; NbExp=3; IntAct=EBI-739832, EBI-356410;
CC Q8TBB1; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-739832, EBI-11959885;
CC Q8TBB1; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-739832, EBI-10171774;
CC Q8TBB1; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-739832, EBI-11953334;
CC Q8TBB1; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-739832, EBI-10241252;
CC Q8TBB1; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-739832, EBI-14065470;
CC Q8TBB1; Q9BYR5: KRTAP4-2; NbExp=7; IntAct=EBI-739832, EBI-10172511;
CC Q8TBB1; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-739832, EBI-3958099;
CC Q8TBB1; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-739832, EBI-1044640;
CC Q8TBB1; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-739832, EBI-1043191;
CC Q8TBB1; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-739832, EBI-11958364;
CC Q8TBB1; Q9BQD3: KXD1; NbExp=4; IntAct=EBI-739832, EBI-739657;
CC Q8TBB1; Q6UWP7: LCLAT1; NbExp=3; IntAct=EBI-739832, EBI-10254507;
CC Q8TBB1; Q13094: LCP2; NbExp=3; IntAct=EBI-739832, EBI-346946;
CC Q8TBB1; O43679: LDB2; NbExp=3; IntAct=EBI-739832, EBI-2865580;
CC Q8TBB1; O95214: LEPROTL1; NbExp=3; IntAct=EBI-739832, EBI-750776;
CC Q8TBB1; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-739832, EBI-10274069;
CC Q8TBB1; P50458: LHX2; NbExp=3; IntAct=EBI-739832, EBI-12179869;
CC Q8TBB1; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-739832, EBI-2341787;
CC Q8TBB1; Q5JTD7: LRRC73; NbExp=3; IntAct=EBI-739832, EBI-12003882;
CC Q8TBB1; Q9Y333: LSM2; NbExp=3; IntAct=EBI-739832, EBI-347416;
CC Q8TBB1; Q9P127: LUZP4; NbExp=3; IntAct=EBI-739832, EBI-10198848;
CC Q8TBB1; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-739832, EBI-1216080;
CC Q8TBB1; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-739832, EBI-742610;
CC Q8TBB1; Q96M61: MAGEB18; NbExp=13; IntAct=EBI-739832, EBI-741835;
CC Q8TBB1; P45984: MAPK9; NbExp=7; IntAct=EBI-739832, EBI-713568;
CC Q8TBB1; Q15555: MAPRE2; NbExp=3; IntAct=EBI-739832, EBI-739717;
CC Q8TBB1; Q9Y316: MEMO1; NbExp=6; IntAct=EBI-739832, EBI-1104564;
CC Q8TBB1; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-739832, EBI-16439278;
CC Q8TBB1; Q8WXB1: METTL21A; NbExp=4; IntAct=EBI-739832, EBI-8652459;
CC Q8TBB1; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-739832, EBI-10172526;
CC Q8TBB1; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-739832, EBI-8852072;
CC Q8TBB1; Q96HT8: MRFAP1L1; NbExp=7; IntAct=EBI-739832, EBI-748896;
CC Q8TBB1; P82932: MRPS6; NbExp=3; IntAct=EBI-739832, EBI-716172;
CC Q8TBB1; Q8NCY6: MSANTD4; NbExp=3; IntAct=EBI-739832, EBI-7850168;
CC Q8TBB1; O60682: MSC; NbExp=3; IntAct=EBI-739832, EBI-740310;
CC Q8TBB1; Q96QG7: MTMR9; NbExp=5; IntAct=EBI-739832, EBI-744593;
CC Q8TBB1; Q5JR59: MTUS2; NbExp=4; IntAct=EBI-739832, EBI-742948;
CC Q8TBB1; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-739832, EBI-11522433;
CC Q8TBB1; Q9H7P6: MVB12B; NbExp=3; IntAct=EBI-739832, EBI-6149062;
CC Q8TBB1; Q9P2K5-2: MYEF2; NbExp=3; IntAct=EBI-739832, EBI-10318831;
CC Q8TBB1; Q15742: NAB2; NbExp=3; IntAct=EBI-739832, EBI-8641936;
CC Q8TBB1; O95544: NADK; NbExp=5; IntAct=EBI-739832, EBI-743949;
CC Q8TBB1; Q9UJ70: NAGK; NbExp=3; IntAct=EBI-739832, EBI-372578;
CC Q8TBB1; Q9UJ70-2: NAGK; NbExp=3; IntAct=EBI-739832, EBI-11526455;
CC Q8TBB1; O43639: NCK2; NbExp=3; IntAct=EBI-739832, EBI-713635;
CC Q8TBB1; O14777: NDC80; NbExp=3; IntAct=EBI-739832, EBI-715849;
CC Q8TBB1; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-739832, EBI-10249760;
CC Q8TBB1; O14561: NDUFAB1; NbExp=3; IntAct=EBI-739832, EBI-1246261;
CC Q8TBB1; P19404: NDUFV2; NbExp=3; IntAct=EBI-739832, EBI-713665;
CC Q8TBB1; Q8N987: NECAB1; NbExp=3; IntAct=EBI-739832, EBI-11956853;
CC Q8TBB1; Q7Z6G3-2: NECAB2; NbExp=6; IntAct=EBI-739832, EBI-10172876;
CC Q8TBB1; Q9HC98: NEK6; NbExp=3; IntAct=EBI-739832, EBI-740364;
CC Q8TBB1; P35240: NF2; NbExp=3; IntAct=EBI-739832, EBI-1014472;
CC Q8TBB1; P15531: NME1; NbExp=3; IntAct=EBI-739832, EBI-741141;
CC Q8TBB1; Q9Y5B8: NME7; NbExp=9; IntAct=EBI-739832, EBI-744782;
CC Q8TBB1; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-739832, EBI-945833;
CC Q8TBB1; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-739832, EBI-22310682;
CC Q8TBB1; O95848: NUDT14; NbExp=8; IntAct=EBI-739832, EBI-536866;
CC Q8TBB1; P37198: NUP62; NbExp=3; IntAct=EBI-739832, EBI-347978;
CC Q8TBB1; Q9NPJ8: NXT2; NbExp=3; IntAct=EBI-739832, EBI-752122;
CC Q8TBB1; Q96M63: ODAD1; NbExp=3; IntAct=EBI-739832, EBI-10173858;
CC Q8TBB1; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-739832, EBI-1054848;
CC Q8TBB1; Q969R2: OSBP2; NbExp=3; IntAct=EBI-739832, EBI-7405817;
CC Q8TBB1; Q969R2-2: OSBP2; NbExp=3; IntAct=EBI-739832, EBI-12211505;
CC Q8TBB1; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-739832, EBI-1051317;
CC Q8TBB1; Q9UJX0: OSGIN1; NbExp=6; IntAct=EBI-739832, EBI-9057006;
CC Q8TBB1; Q9H8K7: PAAT; NbExp=5; IntAct=EBI-739832, EBI-714785;
CC Q8TBB1; Q15102: PAFAH1B3; NbExp=9; IntAct=EBI-739832, EBI-711522;
CC Q8TBB1; P22234: PAICS; NbExp=4; IntAct=EBI-739832, EBI-712261;
CC Q8TBB1; Q9P286: PAK5; NbExp=3; IntAct=EBI-739832, EBI-741896;
CC Q8TBB1; P30039: PBLD; NbExp=3; IntAct=EBI-739832, EBI-750589;
CC Q8TBB1; P61457: PCBD1; NbExp=7; IntAct=EBI-739832, EBI-740475;
CC Q8TBB1; Q13370: PDE3B; NbExp=3; IntAct=EBI-739832, EBI-6172856;
CC Q8TBB1; Q99471: PFDN5; NbExp=3; IntAct=EBI-739832, EBI-357275;
CC Q8TBB1; Q9HB19: PLEKHA2; NbExp=5; IntAct=EBI-739832, EBI-4401947;
CC Q8TBB1; Q8ND90: PNMA1; NbExp=7; IntAct=EBI-739832, EBI-302345;
CC Q8TBB1; Q9UL41: PNMA3; NbExp=3; IntAct=EBI-739832, EBI-11278955;
CC Q8TBB1; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-739832, EBI-10171633;
CC Q8TBB1; P11086: PNMT; NbExp=3; IntAct=EBI-739832, EBI-11305767;
CC Q8TBB1; Q8WZA1: POMGNT1; NbExp=4; IntAct=EBI-739832, EBI-3912424;
CC Q8TBB1; P78424: POU6F2; NbExp=3; IntAct=EBI-739832, EBI-12029004;
CC Q8TBB1; P62937: PPIA; NbExp=3; IntAct=EBI-739832, EBI-437708;
CC Q8TBB1; O43447: PPIH; NbExp=3; IntAct=EBI-739832, EBI-1055615;
CC Q8TBB1; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-739832, EBI-1105153;
CC Q8TBB1; Q9GZV8: PRDM14; NbExp=5; IntAct=EBI-739832, EBI-3957793;
CC Q8TBB1; P31321: PRKAR1B; NbExp=3; IntAct=EBI-739832, EBI-2805516;
CC Q8TBB1; O60260-5: PRKN; NbExp=3; IntAct=EBI-739832, EBI-21251460;
CC Q8TBB1; O75569: PRKRA; NbExp=3; IntAct=EBI-739832, EBI-713955;
CC Q8TBB1; O14744: PRMT5; NbExp=3; IntAct=EBI-739832, EBI-351098;
CC Q8TBB1; P41219: PRPH; NbExp=6; IntAct=EBI-739832, EBI-752074;
CC Q8TBB1; Q9NZ81: PRR13; NbExp=4; IntAct=EBI-739832, EBI-740924;
CC Q8TBB1; Q9NRG1: PRTFDC1; NbExp=3; IntAct=EBI-739832, EBI-739759;
CC Q8TBB1; P62191: PSMC1; NbExp=3; IntAct=EBI-739832, EBI-357598;
CC Q8TBB1; Q9UL46: PSME2; NbExp=3; IntAct=EBI-739832, EBI-741630;
CC Q8TBB1; P61289: PSME3; NbExp=3; IntAct=EBI-739832, EBI-355546;
CC Q8TBB1; Q92530: PSMF1; NbExp=3; IntAct=EBI-739832, EBI-945916;
CC Q8TBB1; Q03393: PTS; NbExp=3; IntAct=EBI-739832, EBI-712344;
CC Q8TBB1; Q96QR8: PURB; NbExp=3; IntAct=EBI-739832, EBI-2880222;
CC Q8TBB1; P47897: QARS1; NbExp=3; IntAct=EBI-739832, EBI-347462;
CC Q8TBB1; Q14088: RAB33A; NbExp=3; IntAct=EBI-739832, EBI-744685;
CC Q8TBB1; P47224: RABIF; NbExp=3; IntAct=EBI-739832, EBI-713992;
CC Q8TBB1; O75771: RAD51D; NbExp=6; IntAct=EBI-739832, EBI-1055693;
CC Q8TBB1; Q9Y620: RAD54B; NbExp=4; IntAct=EBI-739832, EBI-740830;
CC Q8TBB1; Q53GL6: RALY; NbExp=3; IntAct=EBI-739832, EBI-9512693;
CC Q8TBB1; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-739832, EBI-1210429;
CC Q8TBB1; Q9BYM8: RBCK1; NbExp=3; IntAct=EBI-739832, EBI-2340624;
CC Q8TBB1; Q5T481: RBM20; NbExp=3; IntAct=EBI-739832, EBI-11352885;
CC Q8TBB1; P38159: RBMX; NbExp=4; IntAct=EBI-739832, EBI-743526;
CC Q8TBB1; P0DJD3: RBMY1A1; NbExp=4; IntAct=EBI-739832, EBI-8638511;
CC Q8TBB1; Q15415: RBMY1J; NbExp=3; IntAct=EBI-739832, EBI-8642021;
CC Q8TBB1; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-739832, EBI-14065960;
CC Q8TBB1; O75679: RFPL3; NbExp=3; IntAct=EBI-739832, EBI-10188956;
CC Q8TBB1; O76081-6: RGS20; NbExp=3; IntAct=EBI-739832, EBI-10178530;
CC Q8TBB1; Q8IUF8: RIOX2; NbExp=3; IntAct=EBI-739832, EBI-751580;
CC Q8TBB1; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-739832, EBI-396669;
CC Q8TBB1; Q96HH0: ROBO3; NbExp=3; IntAct=EBI-739832, EBI-10288358;
CC Q8TBB1; Q9HAT0: ROPN1; NbExp=5; IntAct=EBI-739832, EBI-1378139;
CC Q8TBB1; P49247: RPIA; NbExp=5; IntAct=EBI-739832, EBI-744831;
CC Q8TBB1; Q6ZNE9: RUFY4; NbExp=6; IntAct=EBI-739832, EBI-10181525;
CC Q8TBB1; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-739832, EBI-11957366;
CC Q8TBB1; Q9Y230: RUVBL2; NbExp=6; IntAct=EBI-739832, EBI-352939;
CC Q8TBB1; P33764: S100A3; NbExp=3; IntAct=EBI-739832, EBI-1044747;
CC Q8TBB1; P04271: S100B; NbExp=3; IntAct=EBI-739832, EBI-458391;
CC Q8TBB1; P21673: SAT1; NbExp=8; IntAct=EBI-739832, EBI-711613;
CC Q8TBB1; Q9UN30-2: SCML1; NbExp=3; IntAct=EBI-739832, EBI-12137487;
CC Q8TBB1; Q9UQR0: SCML2; NbExp=3; IntAct=EBI-739832, EBI-2513111;
CC Q8TBB1; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-739832, EBI-748391;
CC Q8TBB1; Q8WYJ6: SEPTIN1; NbExp=3; IntAct=EBI-739832, EBI-693002;
CC Q8TBB1; Q96ES7: SGF29; NbExp=3; IntAct=EBI-739832, EBI-743117;
CC Q8TBB1; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-739832, EBI-11955083;
CC Q8TBB1; P37840: SNCA; NbExp=3; IntAct=EBI-739832, EBI-985879;
CC Q8TBB1; Q9BV90: SNRNP25; NbExp=3; IntAct=EBI-739832, EBI-9675976;
CC Q8TBB1; P09012: SNRPA; NbExp=3; IntAct=EBI-739832, EBI-607085;
CC Q8TBB1; P62306: SNRPF; NbExp=3; IntAct=EBI-739832, EBI-356900;
CC Q8TBB1; Q02446: SP4; NbExp=3; IntAct=EBI-739832, EBI-10198587;
CC Q8TBB1; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-739832, EBI-742688;
CC Q8TBB1; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-739832, EBI-5235340;
CC Q8TBB1; P12931: SRC; NbExp=6; IntAct=EBI-739832, EBI-621482;
CC Q8TBB1; P84103: SRSF3; NbExp=3; IntAct=EBI-739832, EBI-372557;
CC Q8TBB1; O43805: SSNA1; NbExp=7; IntAct=EBI-739832, EBI-2515299;
CC Q8TBB1; Q6ZMT1: STAC2; NbExp=3; IntAct=EBI-739832, EBI-948802;
CC Q8TBB1; Q9HCH5-13: SYTL2; NbExp=3; IntAct=EBI-739832, EBI-14291493;
CC Q8TBB1; Q9BSH4: TACO1; NbExp=3; IntAct=EBI-739832, EBI-747797;
CC Q8TBB1; Q13148: TARDBP; NbExp=3; IntAct=EBI-739832, EBI-372899;
CC Q8TBB1; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-739832, EBI-529518;
CC Q8TBB1; Q86TI0: TBC1D1; NbExp=3; IntAct=EBI-739832, EBI-1644036;
CC Q8TBB1; Q5QJ74: TBCEL; NbExp=3; IntAct=EBI-739832, EBI-10244795;
CC Q8TBB1; Q99081-3: TCF12; NbExp=3; IntAct=EBI-739832, EBI-11952764;
CC Q8TBB1; P56279: TCL1A; NbExp=3; IntAct=EBI-739832, EBI-749995;
CC Q8TBB1; P48775: TDO2; NbExp=3; IntAct=EBI-739832, EBI-743494;
CC Q8TBB1; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-739832, EBI-750487;
CC Q8TBB1; Q96PF1: TGM7; NbExp=3; IntAct=EBI-739832, EBI-12029034;
CC Q8TBB1; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-739832, EBI-741515;
CC Q8TBB1; Q9BT49: THAP7; NbExp=3; IntAct=EBI-739832, EBI-741350;
CC Q8TBB1; Q9NWX6: THG1L; NbExp=3; IntAct=EBI-739832, EBI-746510;
CC Q8TBB1; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-739832, EBI-11528917;
CC Q8TBB1; Q13829: TNFAIP1; NbExp=3; IntAct=EBI-739832, EBI-2505861;
CC Q8TBB1; P21580: TNFAIP3; NbExp=3; IntAct=EBI-739832, EBI-527670;
CC Q8TBB1; Q13077: TRAF1; NbExp=7; IntAct=EBI-739832, EBI-359224;
CC Q8TBB1; Q12933: TRAF2; NbExp=5; IntAct=EBI-739832, EBI-355744;
CC Q8TBB1; Q13114: TRAF3; NbExp=3; IntAct=EBI-739832, EBI-357631;
CC Q8TBB1; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-739832, EBI-3650647;
CC Q8TBB1; O00463: TRAF5; NbExp=3; IntAct=EBI-739832, EBI-523498;
CC Q8TBB1; Q9Y4K3: TRAF6; NbExp=3; IntAct=EBI-739832, EBI-359276;
CC Q8TBB1; Q9UDY6-2: TRIM10; NbExp=3; IntAct=EBI-739832, EBI-11981577;
CC Q8TBB1; Q14142: TRIM14; NbExp=3; IntAct=EBI-739832, EBI-2820256;
CC Q8TBB1; P19474: TRIM21; NbExp=3; IntAct=EBI-739832, EBI-81290;
CC Q8TBB1; P36406: TRIM23; NbExp=3; IntAct=EBI-739832, EBI-740098;
CC Q8TBB1; P14373: TRIM27; NbExp=3; IntAct=EBI-739832, EBI-719493;
CC Q8TBB1; O75382: TRIM3; NbExp=3; IntAct=EBI-739832, EBI-2129889;
CC Q8TBB1; Q9HCM9: TRIM39; NbExp=3; IntAct=EBI-739832, EBI-739510;
CC Q8TBB1; Q9HCM9-2: TRIM39; NbExp=3; IntAct=EBI-739832, EBI-11523450;
CC Q8TBB1; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-739832, EBI-5235829;
CC Q8TBB1; Q86XT4: TRIM50; NbExp=5; IntAct=EBI-739832, EBI-9867283;
CC Q8TBB1; Q9BYV2: TRIM54; NbExp=7; IntAct=EBI-739832, EBI-2130429;
CC Q8TBB1; Q495X7: TRIM60; NbExp=3; IntAct=EBI-739832, EBI-13576620;
CC Q8TBB1; Q6AZZ1: TRIM68; NbExp=3; IntAct=EBI-739832, EBI-2130449;
CC Q8TBB1; Q9BZR9: TRIM8; NbExp=5; IntAct=EBI-739832, EBI-2340370;
CC Q8TBB1; Q15645: TRIP13; NbExp=8; IntAct=EBI-739832, EBI-358993;
CC Q8TBB1; Q15654: TRIP6; NbExp=3; IntAct=EBI-739832, EBI-742327;
CC Q8TBB1; Q53H54: TRMT12; NbExp=3; IntAct=EBI-739832, EBI-10242598;
CC Q8TBB1; Q86WV8: TSC1; NbExp=3; IntAct=EBI-739832, EBI-12806590;
CC Q8TBB1; Q99816: TSG101; NbExp=3; IntAct=EBI-739832, EBI-346882;
CC Q8TBB1; Q15631: TSN; NbExp=3; IntAct=EBI-739832, EBI-1044160;
CC Q8TBB1; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-739832, EBI-947459;
CC Q8TBB1; Q96PN8: TSSK3; NbExp=7; IntAct=EBI-739832, EBI-3918381;
CC Q8TBB1; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-739832, EBI-7353612;
CC Q8TBB1; Q9Y2X8: UBE2D4; NbExp=5; IntAct=EBI-739832, EBI-745527;
CC Q8TBB1; Q9NZI7: UBP1; NbExp=3; IntAct=EBI-739832, EBI-2795133;
CC Q8TBB1; O95045-2: UPP2; NbExp=3; IntAct=EBI-739832, EBI-11528386;
CC Q8TBB1; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-739832, EBI-11975223;
CC Q8TBB1; Q6EMK4: VASN; NbExp=3; IntAct=EBI-739832, EBI-10249550;
CC Q8TBB1; P55072: VCP; NbExp=7; IntAct=EBI-739832, EBI-355164;
CC Q8TBB1; Q2NL98: VMAC; NbExp=3; IntAct=EBI-739832, EBI-2803134;
CC Q8TBB1; Q9H9H4: VPS37B; NbExp=3; IntAct=EBI-739832, EBI-4400866;
CC Q8TBB1; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-739832, EBI-2799833;
CC Q8TBB1; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-739832, EBI-12032042;
CC Q8TBB1; P63104: YWHAZ; NbExp=3; IntAct=EBI-739832, EBI-347088;
CC Q8TBB1; O96006: ZBED1; NbExp=3; IntAct=EBI-739832, EBI-740037;
CC Q8TBB1; Q8N680: ZBTB2; NbExp=3; IntAct=EBI-739832, EBI-2515601;
CC Q8TBB1; O43167: ZBTB24; NbExp=6; IntAct=EBI-739832, EBI-744471;
CC Q8TBB1; Q9HCK0: ZBTB26; NbExp=3; IntAct=EBI-739832, EBI-3918996;
CC Q8TBB1; O43298: ZBTB43; NbExp=5; IntAct=EBI-739832, EBI-740718;
CC Q8TBB1; Q8TBK6: ZCCHC10; NbExp=3; IntAct=EBI-739832, EBI-597063;
CC Q8TBB1; Q9NTW7: ZFP64; NbExp=4; IntAct=EBI-739832, EBI-711679;
CC Q8TBB1; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-739832, EBI-10183064;
CC Q8TBB1; Q9UQR1-2: ZNF148; NbExp=3; IntAct=EBI-739832, EBI-11742222;
CC Q8TBB1; O14771: ZNF213; NbExp=3; IntAct=EBI-739832, EBI-12838388;
CC Q8TBB1; O14978: ZNF263; NbExp=3; IntAct=EBI-739832, EBI-744493;
CC Q8TBB1; Q9UL40: ZNF346; NbExp=3; IntAct=EBI-739832, EBI-2462313;
CC Q8TBB1; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-739832, EBI-743265;
CC Q8TBB1; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-739832, EBI-740232;
CC Q8TBB1; Q9H707: ZNF552; NbExp=3; IntAct=EBI-739832, EBI-2555731;
CC Q8TBB1; Q9P0T4: ZNF581; NbExp=6; IntAct=EBI-739832, EBI-745520;
CC Q8TBB1; O00488: ZNF593; NbExp=3; IntAct=EBI-739832, EBI-726769;
CC Q8TBB1; Q8N720: ZNF655; NbExp=5; IntAct=EBI-739832, EBI-625509;
CC Q8TBB1; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-739832, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TBB1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TBB1-2; Sequence=VSP_005733;
CC -!- TISSUE SPECIFICITY: Expressed in heart, placenta, kidney, pancreas and
CC brain. {ECO:0000269|PubMed:11521506}.
CC -!- DOMAIN: The NPXY motif is required for the interaction with the PID
CC domain of NUMB. It is however not sufficient.
CC -!- DOMAIN: The PDZ 1 domain participates in the interaction with the PID
CC domain of NUMB, and participates in the isoform-specific ubiquitination
CC of NUMB. The PDZ 2 domain of isoform 2 participates in the interaction
CC with IGSF5/JAM4, other isoforms containing this domain may also
CC interact with IGSF5/JAM4 (By similarity). {ECO:0000250}.
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DR EMBL; AF237782; AAK15039.1; -; mRNA.
DR EMBL; AY358326; AAQ88692.1; -; mRNA.
DR EMBL; AK056823; BAB71291.1; -; mRNA.
DR EMBL; AC058822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC095040; AAY41000.1; -; Genomic_DNA.
DR EMBL; BC022983; AAH22983.1; -; mRNA.
DR EMBL; BC034737; AAH34737.1; -; mRNA.
DR CCDS; CCDS3492.1; -. [Q8TBB1-2]
DR CCDS; CCDS47057.1; -. [Q8TBB1-1]
DR RefSeq; NP_001119800.1; NM_001126328.2. [Q8TBB1-1]
DR RefSeq; NP_116011.2; NM_032622.2. [Q8TBB1-2]
DR RefSeq; XP_005265842.1; XM_005265785.4. [Q8TBB1-1]
DR RefSeq; XP_016864265.1; XM_017008776.1.
DR PDB; 3B76; X-ray; 1.75 A; A/B=504-594.
DR PDB; 5H7R; X-ray; 1.70 A; D=11-138.
DR PDB; 5H7S; X-ray; 3.49 A; B/D=11-138.
DR PDBsum; 3B76; -.
DR PDBsum; 5H7R; -.
DR PDBsum; 5H7S; -.
DR AlphaFoldDB; Q8TBB1; -.
DR SMR; Q8TBB1; -.
DR BioGRID; 124219; 568.
DR ELM; Q8TBB1; -.
DR IntAct; Q8TBB1; 418.
DR MINT; Q8TBB1; -.
DR STRING; 9606.ENSP00000263925; -.
DR MoonDB; Q8TBB1; Predicted.
DR iPTMnet; Q8TBB1; -.
DR PhosphoSitePlus; Q8TBB1; -.
DR BioMuta; LNX1; -.
DR DMDM; 29840786; -.
DR jPOST; Q8TBB1; -.
DR MassIVE; Q8TBB1; -.
DR PaxDb; 9606-ENSP00000263925; -.
DR PeptideAtlas; Q8TBB1; -.
DR ProteomicsDB; 73982; -. [Q8TBB1-1]
DR ProteomicsDB; 73983; -. [Q8TBB1-2]
DR Antibodypedia; 1114; 259 antibodies from 29 providers.
DR DNASU; 84708; -.
DR Ensembl; ENST00000263925.8; ENSP00000263925.7; ENSG00000072201.14. [Q8TBB1-1]
DR Ensembl; ENST00000306888.6; ENSP00000302879.2; ENSG00000072201.14. [Q8TBB1-2]
DR GeneID; 84708; -.
DR KEGG; hsa:84708; -.
DR MANE-Select; ENST00000263925.8; ENSP00000263925.7; NM_001126328.3; NP_001119800.1.
DR UCSC; uc003haf.5; human. [Q8TBB1-1]
DR AGR; HGNC:6657; -.
DR CTD; 84708; -.
DR DisGeNET; 84708; -.
DR GeneCards; LNX1; -.
DR HGNC; HGNC:6657; LNX1.
DR HPA; ENSG00000072201; Low tissue specificity.
DR MIM; 609732; gene.
DR neXtProt; NX_Q8TBB1; -.
DR OpenTargets; ENSG00000072201; -.
DR PharmGKB; PA30419; -.
DR VEuPathDB; HostDB:ENSG00000072201; -.
DR eggNOG; KOG0297; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000158757; -.
DR HOGENOM; CLU_021213_0_0_1; -.
DR InParanoid; Q8TBB1; -.
DR OMA; NHNMAPA; -.
DR OrthoDB; 3028121at2759; -.
DR PhylomeDB; Q8TBB1; -.
DR TreeFam; TF330709; -.
DR PathwayCommons; Q8TBB1; -.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8TBB1; -.
DR SIGNOR; Q8TBB1; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 84708; 10 hits in 1194 CRISPR screens.
DR ChiTaRS; LNX1; human.
DR EvolutionaryTrace; Q8TBB1; -.
DR GeneWiki; LNX1; -.
DR GenomeRNAi; 84708; -.
DR Pharos; Q8TBB1; Tbio.
DR PRO; PR:Q8TBB1; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8TBB1; Protein.
DR Bgee; ENSG00000072201; Expressed in esophagus squamous epithelium and 186 other cell types or tissues.
DR ExpressionAtlas; Q8TBB1; baseline and differential.
DR Genevisible; Q8TBB1; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd16779; mRING-HC-C3HC3D_LNX1; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR19964:SF14; E3 UBIQUITIN-PROTEIN LIGASE LNX; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Metal-binding;
KW Phosphoprotein; Reference proteome; Repeat; Transferase;
KW Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1..728
FT /note="E3 ubiquitin-protein ligase LNX"
FT /id="PRO_0000055913"
FT DOMAIN 274..359
FT /note="PDZ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 381..464
FT /note="PDZ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 507..593
FT /note="PDZ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 638..724
FT /note="PDZ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT ZN_FING 41..79
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 178..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..244
FT /note="Interaction with MAGEB18"
FT /evidence="ECO:0000269|PubMed:20864041"
FT REGION 475..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 181..184
FT /note="NPXY motif"
FT COMPBIAS 475..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 441
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..127
FT /note="MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPL
FT DTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHC
FT TQVLQRCDLEHHFQTS -> MKALLLLVLPWLSPANYIDNVGNLHFLYSEL (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11521506,
FT ECO:0000303|PubMed:12975309, ECO:0000303|PubMed:15489334"
FT /id="VSP_005733"
FT CONFLICT 132
FT /note="S -> F (in Ref. 1; AAK15039)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="G -> R (in Ref. 3; BAB71291)"
FT /evidence="ECO:0000305"
FT CONFLICT 366
FT /note="N -> T (in Ref. 3; BAB71291)"
FT /evidence="ECO:0000305"
FT CONFLICT 411
FT /note="V -> A (in Ref. 3; BAB71291)"
FT /evidence="ECO:0000305"
FT TURN 15..17
FT /evidence="ECO:0007829|PDB:5H7R"
FT HELIX 37..39
FT /evidence="ECO:0007829|PDB:5H7R"
FT TURN 42..44
FT /evidence="ECO:0007829|PDB:5H7R"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:5H7R"
FT STRAND 49..53
FT /evidence="ECO:0007829|PDB:5H7R"
FT STRAND 59..61
FT /evidence="ECO:0007829|PDB:5H7R"
FT HELIX 62..71
FT /evidence="ECO:0007829|PDB:5H7R"
FT TURN 76..78
FT /evidence="ECO:0007829|PDB:5H7R"
FT HELIX 84..86
FT /evidence="ECO:0007829|PDB:5H7R"
FT HELIX 92..99
FT /evidence="ECO:0007829|PDB:5H7R"
FT STRAND 102..104
FT /evidence="ECO:0007829|PDB:5H7R"
FT TURN 108..110
FT /evidence="ECO:0007829|PDB:5H7R"
FT STRAND 114..116
FT /evidence="ECO:0007829|PDB:5H7R"
FT HELIX 117..119
FT /evidence="ECO:0007829|PDB:5H7R"
FT HELIX 120..126
FT /evidence="ECO:0007829|PDB:5H7R"
FT HELIX 129..133
FT /evidence="ECO:0007829|PDB:5H7R"
FT STRAND 504..511
FT /evidence="ECO:0007829|PDB:3B76"
FT STRAND 520..524
FT /evidence="ECO:0007829|PDB:3B76"
FT STRAND 535..540
FT /evidence="ECO:0007829|PDB:3B76"
FT HELIX 545..549
FT /evidence="ECO:0007829|PDB:3B76"
FT STRAND 557..561
FT /evidence="ECO:0007829|PDB:3B76"
FT HELIX 566..568
FT /evidence="ECO:0007829|PDB:3B76"
FT HELIX 571..579
FT /evidence="ECO:0007829|PDB:3B76"
FT STRAND 583..594
FT /evidence="ECO:0007829|PDB:3B76"
SQ SEQUENCE 728 AA; 80629 MW; 5590E8D8976AE093 CRC64;
MNQPESANDP EPLCAVCGQA HSLEENHFYS YPEEVDDDLI CHICLQALLD PLDTPCGHTY
CTLCLTNFLV EKDFCPMDRK PLVLQHCKKS SILVNKLLNK LLVTCPFREH CTQVLQRCDL
EHHFQTSCKG ASHYGLTKDR KRRSQDGCPD GCASLTATAP SPEVSAAATI SLMTDEPGLD
NPAYVSSAED GQPAISPVDS GRSNRTRARP FERSTIRSRS FKKINRALSV LRRTKSGSAV
ANHADQGREN SENTTAPEVF PRLYHLIPDG EITSIKINRV DPSESLSIRL VGGSETPLVH
IIIQHIYRDG VIARDGRLLP GDIILKVNGM DISNVPHNYA VRLLRQPCQV LWLTVMREQK
FRSRNNGQAP DAYRPRDDSF HVILNKSSPE EQLGIKLVRK VDEPGVFIFN VLDGGVAYRH
GQLEENDRVL AINGHDLRYG SPESAAHLIQ ASERRVHLVV SRQVRQRSPD IFQEAGWNSN
GSWSPGPGER SNTPKPLHPT ITCHEKVVNI QKDPGESLGM TVAGGASHRE WDLPIYVISV
EPGGVISRDG RIKTGDILLN VDGVELTEVS RSEAVALLKR TSSSIVLKAL EVKEYEPQED
CSSPAALDSN HNMAPPSDWS PSWVMWLELP RCLYNCKDIV LRRNTAGSLG FCIVGGYEEY
NGNKPFFIKS IVEGTPAYND GRIRCGDILL AVNGRSTSGM IHACLARLLK ELKGRITLTI
VSWPGTFL
//
