ID LRC46_RAT Reviewed; 323 AA.
AC Q6AXZ2;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 08-NOV-2023, entry version 101.
DE RecName: Full=Leucine-rich repeat-containing protein 46;
GN Name=Lrrc46;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-178; SER-179 AND SER-303, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
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DR EMBL; BC079258; AAH79258.1; -; mRNA.
DR RefSeq; NP_001004201.1; NM_001004201.1.
DR AlphaFoldDB; Q6AXZ2; -.
DR SMR; Q6AXZ2; -.
DR STRING; 10116.ENSRNOP00000013542; -.
DR iPTMnet; Q6AXZ2; -.
DR PhosphoSitePlus; Q6AXZ2; -.
DR PaxDb; 10116-ENSRNOP00000013542; -.
DR GeneID; 287653; -.
DR KEGG; rno:287653; -.
DR UCSC; RGD:1303311; rat.
DR AGR; RGD:1303311; -.
DR CTD; 90506; -.
DR RGD; 1303311; Lrrc46.
DR eggNOG; KOG0531; Eukaryota.
DR InParanoid; Q6AXZ2; -.
DR OrthoDB; 5324301at2759; -.
DR PhylomeDB; Q6AXZ2; -.
DR PRO; PR:Q6AXZ2; -.
DR Proteomes; UP000002494; Unplaced.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF1; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46; 1.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Coiled coil; Leucine-rich repeat; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..323
FT /note="Leucine-rich repeat-containing protein 46"
FT /id="PRO_0000223922"
FT REPEAT 49..70
FT /note="LRR 1"
FT REPEAT 71..92
FT /note="LRR 2"
FT REPEAT 93..114
FT /note="LRR 3"
FT REPEAT 115..135
FT /note="LRR 4"
FT DOMAIN 146..188
FT /note="LRRCT"
FT REGION 252..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 203..228
FT /evidence="ECO:0000255"
FT COMPBIAS 267..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 178
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 185
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DAP0"
FT MOD_RES 186
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DAP0"
FT MOD_RES 303
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 323 AA; 36003 MW; DB552AED76CD2CFA CRC64;
MPGDKQEAKN ATQKTEEGVH ITEALITKRN LTFPEDEDLS EKMFHTLDDL ETVRLDGEGI
TCIGNLERLR NIHSLYLQSN KIQRIENLAC ITSLRFLSLA GNQIRHVENL LDLQYLQFLD
LSENLIETLK LDELPQSLLI LNLCGNPCTN QDGYRKMVIG ALPLLLDLDK QPILERWTSD
EEDKSSDEEE EFPELNGPFC AERGFFKDLE QELHQHQERR QQAALTEHLS RMETQPVLTD
LPLLPAVPMA GDCSPAVTEE PGKEAAPKAT SSTQMASSSK KQVPRNQKGS VQARKGALAA
TASKTSLAAA PSMTKSTNKR GTK
//
