ID LYTR_STAAM Reviewed; 246 AA.
AC P60609; P96456;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=Transcriptional regulatory protein LytR;
DE AltName: Full=Sensory transduction protein LytR;
GN Name=lytR; OrderedLocusNames=SAV0261;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
RN [2]
RP FUNCTION, SUBUNIT, AND PHOSPHORYLATION.
RX PubMed=27127614; DOI=10.12688/f1000research.6213.2;
RA Patel K., Golemi-Kotra D.;
RT "Signaling mechanism by the Staphylococcus aureus two-component system
RT LytSR: role of acetyl phosphate in bypassing the cell membrane electrical
RT potential sensor LytS.";
RL F1000Research 4:79-79(2015).
CC -!- FUNCTION: Member of the two-component regulatory system LytR/LytS that
CC regulates genes involved in autolysis, programmed cell death, biofilm
CC formation and cell wall metabolism. Participates also in sensing and
CC responding to host defense cationic antimicrobial peptides (HDPs). Upon
CC phosphorylation by LytS, functions as a transcription regulator by
CC direct binding to promoter regions of target genes including lrgA and
CC lrgB, to positively regulate their expression.
CC {ECO:0000250|UniProtKB:P60611}.
CC -!- SUBUNIT: Homodimer; when phosphorylated. {ECO:0000269|PubMed:27127614}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated and dephosphorylated by LytS.
CC {ECO:0000269|PubMed:27127614}.
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DR EMBL; BA000017; BAB56423.1; -; Genomic_DNA.
DR RefSeq; WP_000645452.1; NC_002758.2.
DR AlphaFoldDB; P60609; -.
DR SMR; P60609; -.
DR KEGG; sav:SAV0261; -.
DR HOGENOM; CLU_000445_14_1_9; -.
DR PhylomeDB; P60609; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR CDD; cd17532; REC_LytTR_AlgR-like; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 2.40.50.1020; LytTr DNA-binding domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR046947; LytR-like.
DR InterPro; IPR007492; LytTR_DNA-bd_dom.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR37299:SF1; STAGE 0 SPORULATION PROTEIN A HOMOLOG; 1.
DR PANTHER; PTHR37299; TRANSCRIPTIONAL REGULATOR-RELATED; 1.
DR Pfam; PF04397; LytTR; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00850; LytTR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR PROSITE; PS50930; HTH_LYTTR; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..246
FT /note="Transcriptional regulatory protein LytR"
FT /id="PRO_0000081127"
FT DOMAIN 2..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 141..245
FT /note="HTH LytTR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 246 AA; 28221 MW; 4DC650CF75019F53 CRC64;
MKALIIDDEP LARNELTYLL NEIGGFEEIN EAENVKETLE ALLINQYDII FLDVNLMDEN
GIELGAKIQK MKEPPAIIFA TAHDQYAVQA FELNATDYIL KPFGQKRIEQ AVNKVRATKA
KDDNNASAIA NDMSANFDQS LPVEIDDKIH MLKQQNIIGI GTHNGITTIH TTNHKYETTE
PLNRYEKRLN PTYFIRIHRS YIINTKHIKE VQQWFNYTYM VILTNGVKMQ VGRSFMKDFK
ASIGLL
//
