ID M0BG04_9EURY Unreviewed; 736 AA.
AC M0BG04;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Archaeal Rqc2 homolog aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=C479_14508 {ECO:0000313|EMBL:ELZ08559.1};
OS Halovivax asiaticus JCM 14624.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Halovivax.
OX NCBI_TaxID=1227490 {ECO:0000313|EMBL:ELZ08559.1, ECO:0000313|Proteomes:UP000011560};
RN [1] {ECO:0000313|EMBL:ELZ08559.1, ECO:0000313|Proteomes:UP000011560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 14624 {ECO:0000313|EMBL:ELZ08559.1,
RC ECO:0000313|Proteomes:UP000011560};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- FUNCTION: Probably part of the ribosome quality control system (RQC).
CC May mediate the addition of alanine residues (Ala tailing) to
CC incompletely synthesized nascent chains from stalled ribosomes, leading
CC to their degradation. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELZ08559.1}.
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DR EMBL; AOIQ01000021; ELZ08559.1; -; Genomic_DNA.
DR RefSeq; WP_007704086.1; NZ_AOIQ01000021.1.
DR AlphaFoldDB; M0BG04; -.
DR STRING; 1227490.C479_14508; -.
DR PATRIC; fig|1227490.4.peg.2947; -.
DR OrthoDB; 10943at2157; -.
DR Proteomes; UP000011560; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_A; RqcH_A; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043681; RqcH_archaeal.
DR NCBIfam; NF041120; RqcH_arch; 1.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00844};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_00844};
KW tRNA-binding {ECO:0000256|HAMAP-Rule:MF_00844}.
FT DOMAIN 526..643
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT REGION 250..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 339..373
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
FT COMPBIAS 253..273
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..505
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 82166 MW; 9E97AD1996B5BFB5 CRC64;
MDPKRELSSV DLAAVVGELS DLEGAKVDKA YLYGDDLVRL KLRDFDRGRV ELFIEVSETK
RVHTVAQERV PDAPGRPPHF AKMLRNRLSG ADFAGVSQYE FDRILEFVFE REDANTRLIV
ELFGEGNVAV TDGEYEVVDS LETIRLKSRT VAPGARYEFP ESRVNPLTVS REAFDRQMDE
SDTDVVRTLA TQLNFGGLYA EELCTRAGVE KTIDIEDAGE SEYERLYGAI ERLAIDVRNG
AFDPRLYLEH EDEEGETEGD SGTDDEAGPT AETDDETEAS GTPVDVTPFP LDEHQQAGLE
PEAFDSFTDA LDEYFYRLEL ADEEPADAAS QRPDFEAEIA KQQRIIEQQE GAIEEFEREA
EAERERAELL YANYGFVDEI LSTVRDARTE GTPWAEIEER FEAGAEQGID AAEAVVDVDG
ANGRVTIELD GERIGLDADD GVEKNADRLY TEGKRIAEKK EGAQQAIENT REELADVRER
KAAWEADDEG SDETGGDDSD EDEPDIDWLA RSSIPIRENE PWFDRFRWVQ TSDGFLVIGG
RNADQNEELV NKYLEPGDRV FHTQAHGGPV TVLKATDPSE SSRPDMEFPE ASIEQAAQFA
VSYASVWKDG RYAGDVYAVD ADQVTKTPES GEYLEKGGFA IRGDRTYHRD TPVDVAVGIQ
CEPWTRVIGG PPAAIADRAV TTIEVEPGQF AQGDVAKRIY RELRERFADE SFVRKIASPD
QLQHFLPPGG SRIKDE
//
