ID M0CH79_9EURY Unreviewed; 623 AA.
AC M0CH79;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=C476_05767 {ECO:0000313|EMBL:ELZ22606.1};
OS Natrinema limicola JCM 13563.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=1230457 {ECO:0000313|EMBL:ELZ22606.1, ECO:0000313|Proteomes:UP000011615};
RN [1] {ECO:0000313|EMBL:ELZ22606.1, ECO:0000313|Proteomes:UP000011615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 13563 {ECO:0000313|EMBL:ELZ22606.1,
RC ECO:0000313|Proteomes:UP000011615};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELZ22606.1}.
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DR EMBL; AOIT01000027; ELZ22606.1; -; Genomic_DNA.
DR RefSeq; WP_008010791.1; NZ_AOIT01000027.1.
DR AlphaFoldDB; M0CH79; -.
DR STRING; 1230457.C476_05767; -.
DR PATRIC; fig|1230457.4.peg.1155; -.
DR eggNOG; arCOG00797; Archaea.
DR OrthoDB; 88793at2157; -.
DR Proteomes; UP000011615; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000011615}.
FT DOMAIN 1..296
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT REGION 162..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..623
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 13..20
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 623 AA; 70572 MW; 83D88F552CD0A815 CRC64;
MATTDTTVTR LFGGPGSGKT TALLDHVEDI LEQDGVTFRD ILVVSYTRAA AQEVRERLAE
RLDESPRALQ GNVCTMHAKA YELLDLSRSD VIGESDKEDF CDEYGIEYED EYSGAGRRTA
RSTTIGNKVI ATSQWLQRTS RDVSDWYDVP FQWDEEEVRL PPEIDPNAQE GNKYTPTWPS
DDDRIDVPEA IRAWRSYKGE QGKIGFADML ERVEQRSLLP NVDYLVIDEF QDITTLQYDV
YEEWKPHMEQ VLIAGDDDQV VYSWQGADPA LLLEEDVDED IILPNSYRLP SNVLNAVNKE
IRHIDQRQDK DLKPRKEGGA VEARTNASML DVVRMVRRTL VEGDGTIMVL FRARYQMFQF
IDEFITEGVP FTSLTDQRMW TDRLTQYVRA VEAIDAGEDV TGLQARRLAD MLQESAFGTN
DRDDLFDEID ERQEDAGIDD LAELMIPAEV ITDHVPFMPG PASASDMLRK VTNFQKKSVR
AYFAIGEYQG MDTDRVRLGT IHSAKGREAD HVFVGTDLTE KVVEQMVATV DDPTDVPHCE
EFTKTTSPVP VLTDNERRVF YVGMSRARER LVLLENLVDG APTLPVDVLL KNELTELTLE
ELVEEAQQPV DDGDADEIEA EAP
//
