ID M0DPJ7_9EURY Unreviewed; 459 AA.
AC M0DPJ7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Xanthine/uracil/vitamin C permease {ECO:0000313|EMBL:ELZ36768.1};
GN ORFNames=C472_09408 {ECO:0000313|EMBL:ELZ36768.1};
OS Halorubrum tebenquichense DSM 14210.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halorubrum.
OX NCBI_TaxID=1227485 {ECO:0000313|EMBL:ELZ36768.1, ECO:0000313|Proteomes:UP000011523};
RN [1] {ECO:0000313|EMBL:ELZ36768.1, ECO:0000313|Proteomes:UP000011523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14210 {ECO:0000313|EMBL:ELZ36768.1,
RC ECO:0000313|Proteomes:UP000011523};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR005353};
CC Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR005353}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697,
CC ECO:0000256|PIRNR:PIRNR005353}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELZ36768.1}.
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DR EMBL; AOJD01000051; ELZ36768.1; -; Genomic_DNA.
DR RefSeq; WP_006629546.1; NZ_AOJD01000051.1.
DR AlphaFoldDB; M0DPJ7; -.
DR PATRIC; fig|1227485.3.peg.1824; -.
DR OrthoDB; 27788at2157; -.
DR Proteomes; UP000011523; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR026033; Azg-like_bact_archaea.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PIRSF; PIRSF005353; PbuG; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR005353};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005353};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|PIRNR:PIRNR005353};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|PIRNR:PIRNR005353};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005353}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 459 AA; 47823 MW; 275E4057926C0A7E CRC64;
MGLSDTLAAR FDVESHGSDV RTELVAGLTT FLAMSYIIVV NPAILSEAIQ IEGYGQGEVF
QMIAIATILS AAVGTVVMAL YANRPFGLAP GLGLNAFFAY TVVLGLGISW QTALAAVFVE
GVLFMLLTAV GAREYVIRLF PEPVKKSVGA GIGLFLLFIG LQELQIVVPD DSTLVTLGGI
FGNPWAILGV LGLVLTFVLW ARNVTGAIVL GIVTTSLAGW GLTLAGFFDR GTITPESLPA
AQYDITPLAG AFVDGLSGID PLTFVLVVFT FFFVDFFDTA GTLIGVSQFG DFLDEDGDLP
DMDRPLMADA VGTTAGAMLG TSTVTTYIES STGVEEGGRT GLTALVVALL FVASLVVIPV
VAAIPAYASF TALIVVGVMM LQGLVEVDWS DPAWAVSAGL TVTVMPFAYS IADGLAAGIV
AYPIIKLAVG EADEVALGQY VIAALLVVYY VLSTRGVIL
//
